Results 31 to 40 of about 2,015,533 (287)

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

The advantages of velocity vector referencing in proportional navigation [PDF]

IEEE Symposium on Position Location and Navigation. A Decade of Excellence in the Navigation Sciences, 2002
Two broad classes of proportional navigation laws are compared with regard to their implementation, analysis, and behavior. The first consists of laws such as the PPN (pure proportional navigation) laws, which are referenced relative to the pursuer velocity vector, and the second consists of line-of-sight (LOS) referenced laws such as TPN (true PN ...
Mahapatra, Pravas R, Shukla, Uday S
openaire   +2 more sources

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

The pion velocity at chiral restoration and the vector manifestation [PDF]

Nuclear Physics A, 2004
13 pages, discussions for clarifying the matching procedure are ...
Harada, Masayasu, Kim, Youngman, Rho, Mannque, Sasaki, Chihiro   +3 more
openaire   +2 more sources

Versatile vector tools for efficient protein screening across multiple expression systems

FEBS Open Bio, EarlyView.
A unified vector toolkit enables rapid protein expression screening across E. coli, insect, and mammalian cells. A single primer pair amplifies the target gene, which is inserted into any vector via a standardized interface. This streamlined workflow eliminates repeated cloning steps, accelerating the identification of optimal expression conditions for
Zhimin Zhu, Yaqing Liu, Lei Qin, Feng Yu, Qisheng Wang, Yahui Liu   +5 more
wiley   +1 more source

Estimation of Velocity Vectors in Synthetic Aperture Ultrasound Imaging [PDF]

IEEE Transactions on Medical Imaging, 2006
A method for determining both velocity magnitude and angle in a synthetic aperture ultrasound system is described. The approach uses directional beamforming along the flow direction and cross correlation to determine velocity magnitude. The angle of the flow is determined from the maximum normalized correlation calculated as a function of angle.
Jørgen Arendt Jensen, Niels Oddershede
openaire   +3 more sources

Structural studies and functional engineering of NanX: an anhydro‐sialic acid transporter from Escherichia coli

FEBS Open Bio, EarlyView.
Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty, Kelsi R. Hall, Zachary D. Tillett, Liam S. Turk, James S. Davies, Michael J. Currie, Hamish G. Brown, Sepideh Valimehr, Peter D. Mace, Andrew E. Whitten, Santosh Panjikar, Eric Hanssen, Rachel A. North, Renwick C.J. Dobson   +13 more
wiley   +1 more source

Purification and preparation of Marchantia polymorpha Auxin Response Factor 2 for phase separation studies

FEBS Open Bio, EarlyView.
We describe detailed protocols for the purification and preparation of Marchantia polymorpha Auxin Response Factor 2 (MpARF2). This protein is fused to an MBP solubility tag and an mNG fluorescent tag and is purified from Escherichia coli. The presented procedures make it possible to study MpARF2 assemblies, which could arise from phase separation ...
Bas Janssen, Robin Romein, Willy A. M. van den Berg, Simon Lindhoud, Jan Willem Borst, Carlo P. M. van Mierlo   +5 more
wiley   +1 more source

Characteristics and Energy Distribution of Blast-Induced Ground Vibration in Deep-Hole Blasting

Buildings, 2023
This study proposes an incremental extreme extraction method based on the waveform characteristics of ground vibration signals obtained from open-pit mines to investigate the distribution and characteristics of ground vibration from deep-hole blasting ...
Shijie Bao, Honglu Fei, Gang Hu
doaj   +1 more source

Vectors as applied to Problems in Velocity [PDF]

Mathematical Notes, 1914
A velocity is a vector quantity, for it possesses magnitude and direction. It is, of course, necessary to make clear in every case what given point (moving or not) is considered as fixed for the time being, to which the vclocity of the moving point (so-called, though it may only be relatively moving) is referred.
openaire   +1 more source