Novel Bispecific Engagers Targeting the CεmX Domain of mIgE‐Expressing Cells
Allergy, EarlyView.We developed bispecific TCE & NKCE targeting the CεmX domain of mIgE to eliminate IgE‐producing cells. Both constructs demonstrated potent, specific, dose‐dependent cytotoxicity and selective immune activation in vitro. These results highlight their promise as off‐the‐shelf, potentially curative therapeutics for IgE‐associated allergic diseases ...
Constantin Möller +16 more
wiley +1 more source
In silico identification of novel antimicrobial peptides from the venom gland transcriptome of the spider Argiope bruennichi (Scopoli, 1772). [PDF]
Front Microbiol, 2023 Shin MK +5 more
europepmc +1 more source
Allergy, EarlyView.ABSTRACT Allergic diseases arise from aberrant immune recognition of otherwise harmless environmental proteins and are driven by epitope‐specific interactions between allergens and the adaptive immune system. Although component‐resolved diagnostics have improved molecular characterisation of sensitization, they remain limited to whole‐allergen ...
Mark Møiniche +11 more
wiley +1 more source
Genome-wide identification, structural homology analysis, and evolutionary diversification of the phospholipase D gene family in the venom gland of three scorpion species. [PDF]
BMC Genomics, 2023 Baradaran M, Salabi F.
europepmc +1 more source
Allergy, EarlyView.ABSTRACT Basophils, the least abundant leukocytes, are increasingly recognised as potent immunomodulators. Upon activation, they rapidly release preformed granule‐associated mediators including histamine and lipid mediators such as LTC4, while cytokine production occurs over a longer timescale, contributing to downstream immune responses.
Jitesh Chauhan +5 more
wiley +1 more source
Understanding the Type 2 Immunity: An Evolving View Beyond Allergic Diseases
Allergy, EarlyView.ABSTRACT Type 2 (T2) immunity is classically associated with defense against helminths and environmental threats, from a physiological perspective, and with allergies and eosinophilic inflammatory diseases, in a pathological sense. However, growing evidence reveals that T2 pathways also support other essential homeostatic functions, including tissue ...
Rodrigo Jiménez‐Saiz +22 more
wiley +1 more source
Short Antimicrobial Peptide Derived from the Venom Gland Transcriptome of Pamphobeteus verdolaga Increases Gentamicin Susceptibility of Multidrug-Resistant Klebsiella pneumoniae. [PDF]
Antibiotics (Basel), 2023 Salinas-Restrepo C +6 more
europepmc +1 more source
Acta Zoologica, EarlyView.ABSTRACT Pedicellariae are small appendages on the surface of the echinoid test, involved in defence, cleaning, and locomotion. Pedicellariae in three species of camarodont sea urchins common in UK waters (Paracentrotus lividus [Lamarck, 1816], Psammechinus miliaris [P.L.S Müller, 1771] and Echinus esculentus [Linnaeus, 1758]) are the focus of this ...
H. C. Reinardy +6 more
wiley +1 more source
Exploring Toxin Genes of Myanmar Russell's Viper, Daboia siamensis, through De Novo Venom Gland Transcriptomics. [PDF]
Toxins (Basel), 2023 Yee KT +3 more
europepmc +1 more source
Influence of friendship on benign and malicious envy among secondary school students
British Journal of Educational Psychology, EarlyView.Abstract Background Benign and malicious envy arise from social comparisons regarding a quality, achievement or possession. As school is inherently evaluative and social, the classroom offers a relevant and understudied context to investigate envy and the impact of friendship on envy. Prior research has shown a positive association between relationship
Flora Fassl +5 more
wiley +1 more source