Results 61 to 70 of about 36,822 (219)

Inhibition of peripheral CB1 receptors modulates food intake and metabolic efficiency in obesity independently of the gut–brain vagal axis

British Journal of Pharmacology, EarlyView.
Background and Purpose Obesity involves profound disruptions in neuronal circuits, neuroendocrine communication and the endocannabinoid system. While global blockade of cannabinoid CB1 receptors improves metabolism, its clinical use is limited by neuropsychiatric side effects.
Oriane Onimus, Camille de Almeida, Benoit Bertrand, Julien Castel, Nejmeh Mashhour, Anthony Ansoult, Serge Luquet, Giuseppe Gangarossa   +7 more
wiley   +1 more source

Mechanical stiffness orchestrates distinct regulation of MRTFs and YAP/TAZ transcriptional cofactors in hepatocytes

The FEBS Journal, EarlyView.
MRTFs and YAP/TAZ proteins, or mechanosensitive transcriptional cofactors (MRTcoF), regulate common genes associated with cellular contractility and immune cell infiltration. Their differential regulation in response to stiffness is linked to changes in hepatocyte's aspect ratio. MRTFB does not undergo nuclear translocation under these conditions. This
Brenda Selene Torres‐Ortiz, Daniel Pérez‐Calixto, Jorge Carretero‐Ortega, Aida Gabriela Guzman‐López, Diana Cristina Pinto‐Dueñas, Mariana Hernández‐Juárez, Alejandra Jiménez‐Escobar, Adriana Rodríguez‐Hernández, Beatriz Díaz‐Bello, Nathalia Serna‐Márquez, Miguel Ángel Peña‐Rico, Laura Gómez‐Romero, Francisco Gabriel Vázquez‐Cuevas, Genaro Vázquez‐Victorio   +13 more
wiley   +1 more source

Chd4 and ThPOK cooperate to preserve structural and electrophysiological integrity of the adult heart through Sprr1a repression

The FEBS Journal, EarlyView.
Chd4/NuRD and ThPOK cooperate to maintain transcriptional repression and nuclear organization in adult cardiomyocytes. Chd4 loss reduces miR‐150‐5p, relieving repression of Sprr1a, while ThPOK loss further enhances Sprr1a activation, possibly through altered chromatin–lamina interactions.
Fadoua El Abdellaoui‐Soussi, Apolonia Novillo, Rocío Brea, Marta Ysbert, Lorena Cussó, Gonzalo Pizarro‐Sánchez, Manuel Desco, Iván Hernández, Ángel Luis Armesilla, Ignacio Pérez de Castro, Alicia R. Folgueras, Juan Miguel Redondo, Pablo Gómez‐del Arco   +12 more
wiley   +1 more source

The Start of a Good Innings, 50 Years of Intensive Care Medicine

World Journal of Surgery, EarlyView.
Jonathan Oliver White, Timothy Craig Hardcastle, David Zonies, Simon Robertson, Sérgio Faria Baptista   +4 more
wiley   +1 more source

Development and implementation of a computerised clinical decision support system for hospital‐in‐the‐home patient identification

Internal Medicine Journal, EarlyView.
ABSTRACT Background Identification of appropriate patients for hospital‐in‐the‐home (HITH) remains a significant challenge. We hypothesise that a human‐centred design (HCD) approach can assist in developing a computerised clinical decision support system (CDSS) to address this issue via leveraging data within the electronic medical record (EMR).
Seok Ming Lim, Thomas Kitt‐Thompson, Douglas Forsyth Johnson, Michael Turner, Adam Boulton, Samantha Plumb, Daniel Capurro, Wen‐Kwang Lim   +7 more
wiley   +1 more source

Mechanical Circulatory Support During Ventricular Tachycardia Ablation: A Systematic Review and Meta‐Analysis of Procedural and Clinical Outcomes

Journal of Cardiovascular Electrophysiology, EarlyView.
ABSTRACT Catheter ablation is an established therapy for ventricular tachycardia (VT); however, hemodynamic instability frequently limits procedural mapping and success. Temporary mechanical circulatory support (tMCS) devices are increasingly used to maintain end‐organ perfusion during VT ablation, yet their impact on clinical outcomes remains ...
Ahmed Nazmy, Hassan El‐Shirbiny, Alaa Abdrabou Abouelmagd, Noha Hammad, Samar Mohamed Sadek, Ahmed Wahdan Kasem, Ahmed Elazab, Reda Biomy, Islam Saboukh, Mohamed Kamal salama, Mohamed Elsaid Abdelfatah, Wael Anwar Haseeb, Maxim Didenko, Vanessa Sciacca, Thomas Fink, Angeliki Darma, Denise Guckel, Moneeb Khalaph, Christian Sohns, Philipp Sommer   +19 more
wiley   +1 more source

The impact of isosmotic conditions on the metabolism and hypoxia tolerance of a reportedly oxyconforming teleost

Journal of Fish Biology, EarlyView.
Abstract Fish must manage the competing demands of ion balance and gas exchange across the gills – a physiological tension known as the osmorespiratory compromise. In dynamic estuarine environments, the osmorespiratory compromise may be exacerbated by variable salinity and periods of hypoxia that demand high respiratory work.
Timothy D. Clark, Luis L. Kuchenmüller, Elizabeth C. Hoots, Maryane Gradito, Jake M. Martin   +4 more
wiley   +1 more source

Pre‐anaesthetic risk assessment and management of dogs with myxomatous mitral valve disease: a spectrum of care narrative review

Journal of Small Animal Practice, EarlyView.
Myxomatous mitral valve disease, an acquired valvular degeneration, is the most common cardiac disorder in dogs, affecting approximately 10% of dogs in primary care veterinary practice. Dogs with myxomatous mitral valve disease frequently require anaesthesia for routine procedures.
I. Levinzon, L. Köster, E. Vettorato, A. H. Estrada   +3 more
wiley   +1 more source

Characterisation of sleep apneas and respiratory circuitry in mice lacking CDKL5

Journal of Sleep Research, Volume 34, Issue 2, April 2025.
Summary CDKL5 deficiency disorder is a rare genetic disease caused by mutations in the CDKL5 gene. Central apneas during wakefulness have been reported in patients with CDKL5 deficiency disorder. Studies on CDKL5‐knockout mice, a CDKL5 deficiency disorder model, reported sleep apneas, but it is still unclear whether these events are central (central ...
Gabriele Matteoli, Sara Alvente, Stefano Bastianini, Chiara Berteotti, Elisabetta Ciani, Elenia Cinelli, Viviana Lo Martire, Giorgio Medici, Tommaso Mello, Elena Miglioranza, Alessandro Silvani, Donatella Mutolo, Giovanna Zoccoli   +12 more
wiley   +1 more source

Confined spaces in space: Cerebral implications of chronic elevations of inspired carbon dioxide and implications for long‐duration space travel

Experimental Physiology, EarlyView.
Abstract Cerebrovascular regulation is critically dependent upon the arterial partial pressure of carbon dioxide (PaCO2${P_{{\mathrm{aC}}{{\mathrm{O}}_{\mathrm{2}}}}}$), owing to its effect on cerebral blood flow, tissue PCO2${P_{{\mathrm{C}}{{\mathrm{O}}_{\mathrm{2}}}}}$, tissue proton concentration, cerebral metabolism and cognitive and neuronal ...
Jay M. J. R. Carr, Philip N. Ainslie, Trevor Day   +2 more
wiley   +1 more source