Results 41 to 50 of about 460,802 (267)
Screening and epitope characterization of Nidogen‐2‐specific nanobodies
FEBS Open Bio, EarlyView.Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen +9 more
wiley +1 more source
Italian Journal of Pediatrics, 2017 Background Seasonal variability on obstructive sleep apnea has already been studied by polysomnography in children. Winter and spring season emerged as critical periods. No data are currently available for pulse oximetry performed at home. The aim of our
Martino Pavone +5 more
doaj +1 more source
FEBS Open Bio, EarlyView.Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero +5 more
wiley +1 more source
Italian Journal of Pediatrics, 2020 Background Children with chronic respiratory failure and/or sleep disordered breathing due to a broad range of diseases may require long-term ventilation to be managed at home.
Martino Pavone +5 more
doaj +1 more source
Hygrothermal Risk in Museum Buildings Located in Moderate Climate
Energies, 2020 Works of art are sensitive to environmental factors—mainly temperature and relative humidity—which, when stable, are generally recommended as ideal protection conditions, but in historical museum buildings, the required conditions are ...
Joanna Ferdyn-Grygierek +5 more
doaj +1 more source
FEBS Open Bio, EarlyView.In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin +12 more
wiley +1 more source
Technological model of building life cycle/Statinio gyvavimo ciklo technologinis modelis
Journal of Civil Engineering and Management, 2001 Under present conditions there are no regulating documents for building life span, maintenance, recondition and reconstruction works and periodicity in Lithuania. The suggested model allows to evaluate optimal values for building work periodicity. The
Vytautas Martinaitis, Artūras Rogoža
doaj +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Onasemnogene abeparvovec (OA) is an AAV9‐based gene therapy for spinal muscular atrophy type I (SMA I). Real‐world outcomes show increased response variability compared to clinical trials, and follow‐up data beyond 12–18 months are limited.
Marika Pane +43 more
wiley +1 more source
Chronic noninvasive ventilation in COPD: towards the identification of a responder phenotype
ERJ Open ResearchPurpose Chronic noninvasive ventilation (NIV) is an effective treatment for patients with chronic hypercapnia due to COPD, but the improvement in health-related quality of life (HRQoL) varies significantly among individuals.
Tim Raveling +4 more
doaj +1 more source
Severe Pediatric Asthma Therapy: Mepolizumab
Frontiers in Pediatrics, 2022 There is a growing need for advanced treatment in children with persistent and severe asthma symptoms. As a matter of fact, between 2 and 5% of asthmatic children experience repeated hospitalizations and poor quality of life despite optimized treatment ...
Nicola Ullmann +8 more
doaj +1 more source