Results 61 to 70 of about 745,496 (300)

Beta1 subunits enable fentanyl‐induced BK channel activation and opioid regulation of cerebral artery diameter

FEBS Open Bio, EarlyView.
During the current opioid crisis, the majority of overdose deaths are attributed to ultra‐potent synthetic opioids, such as fentanyl. While fentanyl exerts its action via opioid receptors, we propose that potassium channels in the brain blood vessels may also sense fentanyl.
Shiwani Thapa, Mohammed Nooh, Akhil Geddati, Alex Dopico, Anna N. Bukiya   +4 more
wiley   +1 more source

Characteristics and outcomes in children on long-term mechanical ventilation: the experience of a pediatric tertiary center in Rome

Italian Journal of Pediatrics, 2020
Background Children with chronic respiratory failure and/or sleep disordered breathing due to a broad range of diseases may require long-term ventilation to be managed at home.
Martino Pavone, Elisabetta Verrillo, Alessandro Onofri, Serena Caggiano, Maria Beatrice Chiarini Testa, Renato Cutrera   +5 more
doaj   +1 more source

Acute Kidney Injury After Mechanical Thrombectomy for Stroke in Patients With Pre‐Existing Renal Impairment

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives Acute kidney injury (AKI) is a common but often underrecognized complication in ischemic stroke patients undergoing mechanical thrombectomy, particularly among those with pre‐existing renal impairment. This study evaluated the incidence, risk factors, and clinical impact of AKI in this high‐risk population.
Michał Borończyk, Marcel Pilarek, Emilia Jaworska, Natalia Kardas, Oliwia Barnaś, Julia Woźniak, Iga Machała, Julia Węgrzynek‐Gallina, Joanna Siuda, Anna Hawrot‐Kawecka, Anetta Lasek‐Bal   +10 more
wiley   +1 more source

Multidimensional assessment of diaphragmatic dysfunction in late-onset Pompe disease: a prospective cohort study

Orphanet Journal of Rare Diseases
Late-onset Pompe disease (LOPD) often leads to progressive respiratory failure due to diaphragmatic involvement. Conventional pulmonary function tests frequently fail to detect early respiratory muscle weakness.
Ana Hernández-Voth, Javier Sayas-Catalán, Marta Corral-Blanco, Miguel Jiménez-Gómez, Gema Carvajal-Cuesta, Cristina Domínguez-González, Laura Bermejo-Guerrero, Paloma Martín-Jiménez, Victoria Villena-Garrido   +8 more
doaj   +1 more source

Technological model of building life cycle/Statinio gyvavimo ciklo technologinis modelis

Journal of Civil Engineering and Management, 2001
Under present conditions there are no regulating documents for building life span, maintenance, recondition and reconstruction works and periodicity in Lithuania. The suggested model allows to evaluate optimal values for building work periodicity. The
Vytautas Martinaitis, Artūras Rogoža
doaj   +1 more source

Prognosis factors and outcome of community-acquired pneumonia needing mechanical ventilation. [PDF]

, 2005
PURPOSE: To evaluate the variables associated with mortality of patients with community-acquired pneumonia who require mechanical ventilation and to determine the attributable morbidity and intensive care unit (ICU) mortality of community-acquired ...
Abroug, F, Frutos Vivar, F., Matanis, D, Tejerina, E, Aspesteguía, C, Anzueto, A., Bugedo, G, Restrepo, M, Bugedo, G., Anzueto, A, Frutos-Vivar, F, Tejerina, E., Restrepo, M.I., Freitas, PT, Abroug, F., Esteban, A, Palizas, F., Esteban, A., Gonzaléz, M, International Mechanical Ventilation Study Group, Gonzalez, M., Matamis, D., Palizas, F, Apezteguia, C.   +23 more
core   +1 more source

Early Clinical, Imaging, and Pathological Characteristics of SRPK3/TTN‐Digenic Myopathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective SRPK3/TTN‐digenic myopathy was recently established as a skeletal muscle myopathy caused by digenic inheritance. This study characterizes the early clinical presentation of SRPK3/TTN‐digenic myopathy in one previously reported and seven newly identified pediatric patients.
Rotem Orbach, Sandra Donkervoort, Carola Hedberg‐Oldfors, Giovanni Baranello, Dimah Saade, Precilla D'Souza, Ruchee Patel, Eva Michael, A. Reghan Foley, Diana Bharucha‐Goebel, S. Jin Haugland, Meghan McAnally, Omer Abdul Hamid, Katherine Chao, Ellen F. Macnamara, Alan H. Beggs, Anna Sarkozy, Juliane Mueller, Steven A. Moore, Richard S. Finkel, Cynthia J. Tifft, Francesco Muntoni, Anders Oldfors, Carsten G. Bönnemann   +23 more
wiley   +1 more source

Chronic noninvasive ventilation in COPD: towards the identification of a responder phenotype

ERJ Open Research
Purpose Chronic noninvasive ventilation (NIV) is an effective treatment for patients with chronic hypercapnia due to COPD, but the improvement in health-related quality of life (HRQoL) varies significantly among individuals.
Tim Raveling, Jorine E. Hartman, Renzo Boersma, Peter J. Wijkstra, Marieke L. Duiverman   +4 more
doaj   +1 more source

Evaluation of Digital Technologies for Home‐Based Assessment in People With Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Digital technologies hold promise for transforming healthcare by enhancing personalized treatments and offer valuable opportunities to improve patient care. Here, we evaluated several novel, self‐administered, home‐based, digital endpoints for their association with corresponding conventional standard clinical measures (primary) in ...
Arne Mueller, Vanessa Vallejo, Mónica Povedano Panadés, Orla Hardiman, Véronique Danel‐Brunaud, Senda Ajroud‐Driss, Philippe Couratier, Jeremy Shefner, Anna Gokey, Mike DiCesare, Erin Lennox, Jens Praestgaard, Lucie Brujin, Peggy Allred, Ram Miller   +14 more
wiley   +1 more source

Bayesian statistics: a primer for perioperative medicine clinicians

Perioperative Medicine
Bayesian methods offer an intuitive and coherent statistical framework for updating probabilistic beliefs by integrating prior knowledge—whether from existing data or expert consensus—with new evidence via likelihood functions to generate posterior ...
Guido Mazzinari, Fernando G. Zampieri, Michael O. Harhay, Marcus J. Schultz, David M. van Meenen, Ary Serpa-Neto   +5 more
doaj   +1 more source