Results 181 to 190 of about 12,813 (237)

Effect of different targeted tidal volumes during high-frequency oscillation with volume-targeted ventilation on cerebral blood flow velocity and cardiac output: study protocol for a randomised crossover study. [PDF]

Trials
Kaltsogianni O, Nanjundappa M, Okoye G, Greenough A, Dassios T.   +4 more
europepmc   +1 more source

Development, validation, and preliminary phenotypic characterization of a Col6a3 knockout mouse model targeting exon 3

Animal Models and Experimental Medicine, EarlyView.
Deleting Col6a3 exon 3 by CRISPR in mice results in centralized nuclei consistent with a myopathy phenotype mimicking collagen VI‐associated human disease Abstract Background Most mutations in the COL6A3 gene lead to collagen VI‐related myopathies. This is due to a reduced expression or mislocalization of the COL6A3 protein.
Michel ElChoueiry, Harsimran Sidhu, Maude Lévesque, Dominique Lévesque, Jean‐François Jacques, Otman Sarrhini, Jean‐François Beaudoin, Molly Caron, Brenda Gaudette, Roger Lecomte, Xavier Roucou, François‐Michel Boisvert, Jean‐Philippe Brosseau   +12 more
wiley   +1 more source

Factors associated with withholding of invasive mechanical ventilation in the early phase of the COVID-19 response and their ethical analyses. [PDF]

GHM Open
Morioka S, Takashima K, Asai Y, Suzuki T, Nomoto H, Saito S, Suzuki K, Suzuki S, Sato L, Nakamura K, Nikaido M, Matsunaga N, Hayakawa K, Mori M, Yamamoto K, Ohmagari N.   +15 more
europepmc   +1 more source

New approaches to treating chronic obstructive pulmonary disease with Colla corii asini

Animal Models and Experimental Medicine, EarlyView.
Colla corii asini improves chronic obstructive pulmonary disease (COPD) treatment through anti‐inflammatory, antioxidant, immune‐modulatory, and lung‐nourishing effects, addressing current therapeutic challenges via multitarget mechanisms. Abstract Chronic obstructive pulmonary disease (COPD) is one of the leading causes of death and disability ...
Wenchao Zhang, Siman Sun, Xiaoyu Fan, Jiuming He, Qing Li, Hongtao Jin   +5 more
wiley   +1 more source

Automatic continuous P_0.1 measurements during weaning from mechanical ventilation: a clinical study. [PDF]

Ann Intensive Care
Delamaire F, Adel M, Pauline G, Quentin Q, Valentin C, Benoit P, Jean-Marc T, Nicolas T, Arnaud G.   +8 more
europepmc   +1 more source

Molecular dynamics of the host response to Streptococcus pneumoniae pneumonia in baboons

Animal Models and Experimental Medicine, EarlyView.
Using an established, clinically relevant nonhuman primate model of S. pneumoniae pneumonia, this study aims to identify novel potential molecular diagnostic and therapeutic targets using peripheral blood bulk transcriptomic, unbiased proteomic, and cytokine measurements. The constructed models were highly accurate in classifying bacterial pneumonia in
Bryan D. Kraft, Ashlee M. Valente, Ephraim L. Tsalik, Micah T. McClain, Marshall Nichols, Thomas W. Burke, Ricardo Henao, Erik J. Soderblom, J. Will Thompson, M. Arthur Moseley, Lori L. Hudson, Timothy Veldman, Olga M. Better, Mert Aydin, Anna Mazur, Karen E. Welty‐Wolf, Claude A. Piantadosi, Geoffrey S. Ginsburg, Christopher W. Woods   +18 more
wiley   +1 more source

Evaluation of flow control using PID versus fuzzy logic in an electropneumatic circuit for pulmonary ventilation applications. [PDF]

PLoS One
González L, Griffith I, Lescher A, Molino J, Rojas A, Quijano D.   +5 more
europepmc   +1 more source

Assessing the therapeutic potential of Tirzepatide in modulating inflammatory responses and mitigating acute pancreatitis

Animal Models and Experimental Medicine, EarlyView.
Tirzepatide: A peptide‐based GLP‐1/GIP receptor agonist, tested on L‐Arginine‐induced pancreatitis. Lipase/Amylase Levels: Initially elevated due to inflammation but normalized with Tirzepatide. Inflammatory Response: Reduction in pro‐inflammatory cytokines (IL‐6) and enhancement of anti‐inflammatory cytokines (IL‐4, IL‐10).
Razan Alawaji, Mohamed S. Abdel‐Bakky, Hussein M. Ali, Miad A. Aljuhani, Abdulaziz Arif A. Alshammari, Hashim K. Kamal, Maamoun M. K. Khoja, Kholoud Alsehemi, Mennatallah A. Korani, Eman S. Said   +9 more
wiley   +1 more source

Ventilator performances for non-invasive ventilation: a bench study. [PDF]

BMJ Open Respir Res
Caillard C, Fresnel E, Artaud-Macari E, Cuvelier A, Tamion F, Patout M, Girault C.   +6 more
europepmc   +1 more source