Results 51 to 60 of about 2,528,395 (329)

The mechanics of mechanical ventilation [PDF]

Revista Médica de Minas Gerais, 2014
The Ventilator has represented an advance in the respiratory support for patients on anesthesia and intensive care. The ventilatory support increases the chance of survival in patients with respiratory failure, and / or major surgical procedures. This paper consists of a summary of advances in the ventilatory support, in describing the physiological ...
Renan Murta Soares de Almeida, Aline Siqueira Melo, Cláudio Dornas de Oliveira   +2 more
openaire   +1 more source

Actual performance of mechanical ventilators in ICU: a multicentric quality control study

Medical devices, 2012
Even if the performance of a given ventilator has been evaluated in the laboratory under very well controlled conditions, inappropriate maintenance and lack of long-term stability and accuracy of the ventilator sensors may lead to ventilation errors in ...
L. Govoni, R. Dellaca’, Ó. Peñuelas, G. Bellani, A. Artigas, M. Ferrer, D. Navajas, A. Pedotti, R. Farré   +8 more
semanticscholar   +1 more source

The implausibility of ‘usual care’ in an open system: sedation and weaning practices in Paediatric Intensive Care Units (PICUs) in the United Kingdom (UK) [PDF]

, 2015
Background: The power of the randomised controlled trial depends upon its capacity to operate in a closed system whereby the intervention is the only causal force acting upon the experimental group and absent in the control group, permitting a valid ...
B Ambuel, B Blackwood, B Blackwood, B Blackwood, B Blackwood, Bronagh Blackwood, C Maloney, CJL Newth, D Bieri, D Macrae, DL Jackson, E Ista, E Ista, F Frutos-Vivar, FK Foronda, FW Moler, J Rycroft-Malone, J Rycroft-Malone, J Rycroft-Malone, JA Durlak, K Harron, L Kohn, L Rose, LS Franck, Lyvonne Tume, M Cunliffe, NJ Vet, P O’Halloran, PA Jouvet, RP Dellinger, S Chawla, S Playfor, SI Merkel, SW Krechel, YN Poh   +34 more
core   +1 more source

A Novel Mixed Finite/Infinite Dimensional Port–Hamiltonian Model of a Mechanical Ventilator

Computation
Mechanical ventilation is a life-saving treatment for critically ill patients who are struggling to breathe independently due to injury or disease. Globally, per year, there has always been a large number of individuals who have required mechanical ...
Milka C. I. Madahana, John E. D. Ekoru, Otis T. C. Nyandoro   +2 more
doaj   +1 more source

Design and performance testing of a novel emergency ventilator for in-hospital use

Canadian Journal of Respiratory Therapy, 2020
Background The rapidly evolving COVID-19 pandemic has led to increased use of critical care resources, particularly mechanical ventilators. Amidst growing concerns that the health care system could face a shortage of ventilators in the future, there is ...
Knorr Jacob M., Sheehan Megan M., Santana Daniel C., Samorezov Sergey, Sammour Ibrahim, Deblock Michael, Kuban Barry, Chaisson Neal, Chatburn Robert L.   +8 more
doaj   +1 more source

Cost effectiveness of ward based non-invasive ventilation for acute exacerbations of chronic obstructive pulmonary disease: economic analysis of randomised controlled trial [PDF]

, 2003
OBJECTIVE: To evaluate the cost effectiveness of standard treatment with and without the addition of ward based non-invasive ventilation in patients admitted to hospital with an acute exacerbation of chronic obstructive pulmonary disease.
Elliott, M.W., Owen, J.L., Parrott, S., Plant, P.K.   +3 more
core   +2 more sources

Mechanistic basis for inhibition of the extended‐spectrum β‐lactamase GES‐1 by enmetazobactam and tazobactam

FEBS Letters, EarlyView.
Antimicrobial resistance (AMR) is of huge importance, resulting in over 1 million deaths each year. Here, we describe how a new drug, enmetazobactam, designed to help fight resistant bacterial diseases, inhibits a key enzyme (GES‐1) responsible for AMR. Our data show it is a more potent inhibitor than the related tazobactam, with high‐level computation
Michael Beer, Philip Hinchliffe, Marko Hanževački, Christopher R. Bethel, Catherine L. Tooke, Marc W. Van der Kamp, Krisztina M. Papp‐Wallace, Robert A. Bonomo, Stuart Shapiro, Adrian J. Mulholland, James Spencer   +10 more
wiley   +1 more source

Trauma and Critical Care for the Senior Medical Student Entering Surgery

MedEdPORTAL, 2014
Introduction Skills to aid in the management of trauma patients and critically ill surgical patients in the intensive care setting are important topics that are not uniformly covered in medical schools.
Mara Antonoff, Courtney Green, Jonathan D'Cunha   +2 more
doaj   +1 more source

Increasing compliance with low tidal volume ventilation in the ICU with two nudge-based interventions: evaluation through intervention time-series analyses [PDF]

, 2016
Objectives: Low tidal volume (TVe) ventilation improves outcomes for ventilated patients, and the majority of clinicians state they implement it. Unfortunately, most patients never receive low TVes.
Bourdeaux, C. P., Gilchrist, I. D., Gould, T. H., Jarvstad, A., Jones, T., Malhotra, G., Thomas, M. J. C.   +6 more
core   +3 more sources

BMP antagonist CHRDL2 enhances the cancer stem‐cell phenotype and increases chemotherapy resistance in colorectal cancer

Molecular Oncology, EarlyView.
Overexpression of CHRDL2 in colon cancer cells makes them more stem‐like and resistant to chemo‐ and radiotherapy. CHRDL2‐high cells have upregulation of the WNT pathway, genes involved in the DNA damage response (DDR) pathway and epithelial‐to‐mesenchymal transition (EMT). This leads to quicker repair of damaged DNA and more cell migration.
Eloise Clarkson, Annabelle Lewis
wiley   +1 more source