Results 51 to 60 of about 48,379 (295)

β‐Catenin/c‐Myc Axis Modulates Autophagy Response to Different Ammonia Concentrations

Advanced Biology, Volume 9, Issue 3, March 2025.
Ammonia, detoxified by the liver into urea and glutamine, impacts autophagy differently at varying levels. Low ammonia activates autophagy via c‐Myc and β‐catenin, while high levels suppress it. Using Huh7 cells and Spf‐ash mice, c‐Myc's role in cytoprotective autophagy is revealed, offering insights into hyperammonemia and potential therapeutic ...
S. Sergio, B. Spedicato, G. Corallo, A. Inguscio, M. Greco, D. Musarò, D. Vergara, A. F. Muro, G. De Sabbata, L. R. Soria, N. Brunetti Pierri, M. Maffia   +11 more
wiley   +1 more source

Novel design of inspiratory flow generation and gas mixing for critical care ventilators suitable for rapid production and mass casualty incidents

Scientific Reports, 2023
Scarcity of medical resources inspired many teams worldwide to design ventilators utilizing different approaches during the recent COVID-19 pandemic.
Karel Roubik, Vaclav Ort, Lenka Horakova, Simon Walzel   +3 more
doaj   +1 more source

Advanced Flame Retardant Strategies and Fire Performance Assessment for Safer Photovoltaics in Buildings: A Two‐Part Review

Advanced Functional Materials, EarlyView.
The integration of photovoltaic (PV) systems into building structures introduces distinct fire risks with critical implications for occupant safety. This review examines the key fire hazards associated with PV implementation and explores mitigation strategies, including flame‐retardant additives.
Florian Ollagnon, Olaia Aurrekoetxea‐Arratibel, Emma Gottis, Heng‐Yu Li, Xabier Olano‐Azkune, Matthieu Despeisse, Antonin Faes, Christophe Ballif   +7 more
wiley   +1 more source

Next‐Generation Bio‐Reducible Lipids Enable Enhanced Vaccine Efficacy in Malaria and Primate Models

Advanced Functional Materials, EarlyView.
Structure–activity relationship (SAR) optimization of bio‐reducible ionizable lipids enables the development of highly effective lipid nanoparticle (LNP) mRNA vaccines. Lead LNPs show superior tolerability and antibody responses in rodents and primates, outperforming approved COVID‐19 vaccine lipids.
Ruben De Coen, Sabah Kasmi, Shrinivas Dumbre, Lies Baekens, Elise Seynaeve, Louise Van den Hauwe, Niccolò Cantini, Aello Garantoudi, Filipe Branco Madeira, Alain Marrot, Emma Tuypens, Sofie Seghers, Anna Kuchmiy, Elisabeth Brabants, Bart Vanderborght, Ine Maes, Sarah Vandenberghe, Jessica Filtjens, Alícia Gordún Peiró, Daliya Kancheva, Ayla Debraekeleer, Florence Lambolez, Emily De Lombaerde, Yong Chen, Rafael Miyazawa Martins, Pauline Formaglio, Damya Laoui, Sofie Deschoemaeker, Bruno G. De Geest, Rogerio Amino, Stefaan De Koker   +30 more
wiley   +1 more source

O uso da hiperinsuflação como recurso fisioterapêutico em unidade de terapia intensiva The use of hyperinflation as a physical therapy resource in intensive care unit

Revista Brasileira de Terapia Intensiva, 2007
JUSTIFICATIVA E OBJETIVOS: Os pacientes ventilados mecanicamente geralmente apresentam grandes quantidades de secreção pulmonar devido à deficiência da função mucociliar e do transporte de muco.
Daniela Aires Lemes, Fernando Silva Guimarães   +1 more
doaj   +1 more source

Demand and supply of invasive and noninvasive ventilators at the peak of the COVID‐19 outbreak in Okinawa

Journal of General and Family Medicine, 2020
While Okinawa has been facing outbreak of the coronavirus disease 2019 (COVID‐19) pandemic, healthcare collapse should be prevented by sufficient supply of ventilators for caring the rapidly growing number of critically ill patients with COVID‐19.
Toshikazu Kuniya, Yasunori Nakama, Yasuharu Tokuda   +2 more
doaj   +1 more source

A Bespoke Programmable Interpenetrating Elastomer Network Composite Laryngeal Stent for Expedited Paediatric Laryngotracheal Reconstruction

Advanced Functional Materials, EarlyView.
A programmable interpenetrating double‐network architecture, created via 3D‐TIPS printing and resin infusion, synergistically combines thermoplastic and thermosetting elastomers to balance structural rigidity and surface softness—crucial for paediatric laryngeal stents.
Elizabeth F. Maughan, Lei Wu, Dong Zhang, Linxiao Wu, Graca Ferreira Vaz Pinto Mendes, Wanqiao J. Tu, Heping Ma, Toby J. Proctor, Colin R. Butler, Thomas Kjærgaard, Mark W. Lowdell, Martin A. Birchall, Robert E. Hynds, Richard Hewitt, Wenhui Song   +14 more
wiley   +1 more source

Reviving Decommissioned Ventilators How a Circular Economy Approach Can Assist in Tackling the South African Shortage of Ventilators during Covid-19

The Thinker, 2020
Sub-Saharan Africa bears the highest disease burden in human and economic costs, but commands less than one percent of global health expenditure (Aikins et al., 2010). Strong health systems are fundamental to maintaining good health. Difficult geography,
Katharina Gihring and Nickey Janse van Rensburg
doaj  

Continuous chest compressions with a simultaneous triggered ventilator in the Munich Emergency Medical Services: a case series

GMS German Medical Science, 2019
Background: Mechanical chest compression devices are commonly used providing a constant force and frequency of chest compression during cardiopulmonary resuscitation.
Schaller, Stefan J., Altmann, Sonja, Unsworth, Annalise, Schneider, Gerhard, Bogner-Flatz, Viktoria, Paul, Thomas, Hoppmann, Petra, Kanz, Karl-Georg   +7 more
doaj   +1 more source

A Scalable, Durable, Fire‐Safe All‐Day Passive Radiative Cooling Coating for Sustainable Buildings

Advanced Functional Materials, EarlyView.
This study reports a scalable, durable coating that combines a fire‑retardant copolymer adhesive, hollow glass microspheres, and boron oxide to achieve passive radiative cooling with over 94% solar reflectance and >95% mid‑infrared emissivity. The coating maintains performance after UV and rain exposure and exhibits UL‑94 V‑0 fire resistance, enabling ...
Zhewen Ma, Yuanhao Feng, Alex Y. Song, Toan Dinh, Min Hong, John Bell, Boyou Hou, Pingan Song, Wei Zheng   +8 more
wiley   +1 more source