Results 51 to 60 of about 134,841 (335)

Disability, Deadly Discourse, and Collectivity amid Coronavirus (COVID-19)

Scandinavian Journal of Disability Research, 2020
As COVID-19 crosses the globe, disabled people are subject to new medical and discursive realities. Focusing on the consequences of the latter, we utilize news reports from Canada and the UK to argue the current language of pre-existing conditions ...
Thomas Abrams, David Abbott
doaj   +1 more source

General Public Preferences for Allocating Scarce Medical Resources During COVID-19

Frontiers in Public Health, 2020
COVID-19 has overwhelmed healthcare systems across the globe with an unprecedented surge in the demand for hospitalizations. Consequently, many hospitals are facing precarious conditions due to limited capacity, especially in the provision of ventilators.
Samir Huseynov, Marco A. Palma, Rodolfo M. Nayga   +2 more
doaj   +1 more source

Quality of nurses’ communication with mechanically ventilated patients in a cardiac surgery intensive care unit

Investigación y Educación en Enfermería, 2019
Objective. To describe the quality of the relationship between nurses and patients under mechanical ventilation. Methods. This observational study, performed in a cardiac surgery intensive care unit in Iran, selected 10 nurses and 35 patients through ...
Marzieh Momennasab, Mohammadreza Shaker Ardakani, Fereshte Dehghan Rad, Roya Dokoohaki, Reza Dakhesh, Azita Jaberi   +5 more
doaj   +1 more source

High-frequency oscillatory ventilation in pediatric acute hypoxemic respiratory failure: disease-specific morbidity survival analysis. [PDF]

, 2012
BackgroundMultiple ventilatory strategies for acute hypoxemic respiratory failure (AHRF) in children have been advocated, including high-frequency oscillatory ventilation (HFOV).
Babbitt, Christopher J, Cooper, Michael C, Levine, Glenn K, Liao, Eileen, Nussbaum, Eliezer, Randhawa, Inderpal S   +5 more
core   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

GlasVent—The Rapidly Deployable Emergency Ventilator

Global Challenges, 2020
As a result of the novel Coronavirus disease (COVID‐19) outbreak, a surge is witnessed in the demand for mechanical ventilators needed for treating affected patients.
Adamos Christou, Markellos Ntagios, Andrew Hart, Ravinder Dahiya   +3 more
doaj   +1 more source

Scoring System to Evaluate the Performance of ICU Ventilators in the Pandemic of COVID-19: A Lung Model Study

Frontiers in Medicine, 2021
Ventilators in the intensive care units (ICU) are life-support devices that help physicians to gain additional time to cure the patients. The aim of the study was to establish a scoring system to evaluate the ventilator performance in the context of ...
Xingshuo Hu, Fei Xie, Kaifei Wang, Hongjun Gu, Guoxin Mo, Ruoxuan Wen, Ying Zhao, Qingyun Yang, Knut Möller, Zhanqi Zhao, Zhanqi Zhao, Lixin Xie   +11 more
doaj   +1 more source

Increasing compliance with low tidal volume ventilation in the ICU with two nudge-based interventions: evaluation through intervention time-series analyses [PDF]

, 2016
Objectives: Low tidal volume (TVe) ventilation improves outcomes for ventilated patients, and the majority of clinicians state they implement it. Unfortunately, most patients never receive low TVes.
Bourdeaux, Christopher P., Bristol Medical School (PHS), Bristol Medical School (THS), Bristol Neuroscience, Bristol Population Health Science Institute, Bristol Vision Institute, Centre for Medical Education, Gilchrist, Iain D., Gould, Timothy H., Jarvstad, Andreas, Jones, Tim, Malhotra, Gaurav, NIHR Applied Research Collaboration West (NIHR ARC West), School of Psychological Science, Thomas, Matthew J. C.   +14 more
core   +4 more sources

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Reusable Areas of Clinically Used Ventilators Carry Low Numbers of Aerobic Bacteria

All Results Journals: Biol, 2014
Ventilator associated pneumonia (VAP) remains a serious problem for critically ill patients. We swabbed nine reusable areas on 20 clinically-used ventilators from a VA Hospital shortly after they had been removed from patients and identified bacterial ...
Elizabeth Anne Gonzalez, Julie Kase, Fassil Getachew, Mark Cowan, Pamela Scott, Iacovos Kyprianou, Barre Jones, Victoria Hitchins   +7 more
doaj   +2 more sources