Results 61 to 70 of about 134,841 (335)
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Optimal greenhouse design should take into account optimal climate management [PDF]
The objective of this paper is to demonstrate that optimal greenhouse design must account for (and be combined to) optimal climate management. We prove this by showing that different strategies and set-points to control the greenhouse ventilators result ...
Henten, E.J., van +3 more
core +2 more sources
African Journal of Disability, 2020 During disasters, when resources and care are scarce, healthcare workers are required to make decisions and prioritise which patients receive life-saving resources over others.
Emma L. McKinney +2 more
doaj +1 more source
Pandemic lockdown must fail: Save lives without crippling the economy [PDF]
, 2020 In the following working paper, I want to make a plea for what I am calling a “reverse quarantine”—quarantining people who are over 65 (who number 52 million), before they get sick.
Hirschhorn, PhD, Larry
core +1 more source
Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source
Improvements in natural air supply concerning thermal winter comfort, IAQ and energy consumption [PDF]
, 2016 The paper presents the effect on thermal conditions, heat consumption and the perception of thermal comfort and indoor air quality (IAQ) of different types of trickle ventilators (pressure controlled at 2 Pa pressure difference or 10 Pa with(out) back ...
Candaele, Arnaud +4 more
core +1 more source
Accuracy of P0.1 measurements performed by ICU ventilators: a bench study
Annals of Intensive Care, 2019 BackgroundOcclusion pressure at 100 ms (P0.1), defined as the negative pressure measured 100 ms after the initiation of an inspiratory effort performed against a closed respiratory circuit, has been shown to be well correlated with central respiratory ...
F. Beloncle +6 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns +10 more
wiley +1 more source
Postgraduate Medical Journal, 1998 SummaryNasal intermittent positive pressure ventilation is likely to have an increasing role in the management of acute ventilatory failure, weaning, and chronic ventilatory problems. Further improvements in ventilator and mask design will be seen.
openaire +2 more sources
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source