Results 101 to 110 of about 27,974 (246)

Single‐Cell Profiling Identifies SLC2A5‐Mediated Fructose Metabolism as a Vulnerability in Primary CNS Lymphoma

Advanced Science, EarlyView.
Glucose deprivation in the primary CNS lymphoma (PCNSL) tumor microenvironment drives SLC2A5 (encoding GLUT5)‐dependent fructose metabolism in tumor cells, while hypoxia induces HIF‐mediated SLC2A5 expression in tumor‐supportive macrophages, revealing SLC2A5‐driven fructose utilization as a shared and targetable metabolic vulnerability across malignant
Qiaoli Wu, Qianru Zhang, Wenqiang Yan, Lu Sun, Yiran Cui, Bolin Liu, Guoqing Han, Feng Zhang, Ke Pu, Mingchao Zhang, Xiaobing Zhang, Qingguo Li, Gang An, Yuxuan Liu   +13 more
wiley   +1 more source

Agreement between heart rate variability‐derived and lactate/ventilatory thresholds during a 4‐min stepwise incremental cycling test in male adults

Physiological Reports
Accurate exercise intensity thresholds are key for endurance training prescription. The non‐linear heart rate (HR) variability (HRV) index DFAa1 has been proposed as a threshold determination marker, with DFAa1 values of 0.75 (HRVT1) and 0.5 (HRVT2 ...
Anton Olieslagers, Yoram Müller‐Jabusch, Margot Vancoillie, Emma Delen, Toon de Beukelaar   +4 more
doaj   +1 more source

Ventilatory Threshold Related to V̇O 2 reserve, Heart Rate Reserve, and Rating of Perceived Exertion in a Large Varied Sample. [PDF]

Med Sci Sports Exerc, 2023
Gaskill SE, Skinner JS, Quindry J.
europepmc   +1 more source

Lactate‐Driven Restriction of Mitochondrial Permeability Transition Promotes Resistance to Chemo‐Immunotherapy by Suppressing Tumor PANoptosis

Advanced Science, EarlyView.
Tumor‐derived lactate establishes a metabolic lock that drives chemo‐immunotherapy resistance by suppressing PANoptosis. Mechanistically, KAT8 lactylates the mitochondrial translocator ANT2, which recruits PGAM5 to dephosphorylate CypD. This cascade restricts mitochondrial permeability transition pore opening, preventing pro‐inflammatory mtDNA leakage.
Sen Zhong, Wenlong Chen, Fanglong Liu, Shengyi Zhou, Bolin Yu, Yuying Wang, Xiqian Zhou, Xuehui Wang, Diya Liu, Zhuoyu Zhang, Xinran Wang, Mounia Lalouly, Yiwen Li, Zhefei Du, Tao Yan, Zhihui Xiao, Zhou Zhou, Huanhuan Zhu, Fengyuan Qian, Bowen Zheng, Lin Fang   +20 more
wiley   +1 more source

The effects of exercise training above and below the ventilatory threshold in patients with coronary artery disease [PDF]

, 1999
grantor: University of TorontoThe differential effects of training above and below the ventilatory threshold (VT) were examined in 35 patients with coronary artery disease (CAD).
Cayen, Barry Robert
core   +2 more sources

Aerobic Capacity, Body Composition, and Ventilatory Thresholds in Youth Endurance Athletes: Physiological Characteristics of Hungarian Junior Triathletes

Applied Sciences
Limited data are available regarding the physiological profile of youth triathletes. The aim of this study was to characterize the physiological and body composition profile of Hungarian youth triathletes and to examine the relationships between ...
Adam Balog, László Suszter, Zoltán Alföldi, István Barthalos, Árpád Petrov, Ferenc Ihász   +5 more
doaj   +1 more source

Heart rate deflection point as an alternative to determining the anaerobic threshold in dyslipidaemic patients

Motriz: Revista de Educacao Fisica, 2019
Aim: The aim of the present study was to verify the agreement between the ventilatory method (VT) and the alternative method of heart rate deflection point (HRDP) in determining the anaerobic threshold (AT) during incremental treadmill test in ...
Rochelle Rocha Costa, Thais Reichert, Bruna Machado Barroso, Vitória de Mello Bones da Rocha, Artur Avelino Birk Preissler, Éder Santiago, Eli Gonçalves Junior, Danielle Girolometto Fracalossi, Rodrigo Sudatti Delevatti, Luiz Fernando Martins Kruel   +9 more
doaj   +1 more source

Bioinspired Passive Flow Routing to Mitigate Thrombosis in Prosthetic Heart Valves and Cardiovascular Devices

Advanced Science, EarlyView.
Bioinspired passive flow routing mitigates thrombosis in cardiovascular devices by redirecting a small fraction of forward flow into stagnation‐prone regions. Inspired by avian alula and aircraft slat mechanisms, strategically placed routing channels restore washout around mechanical heart valves, reducing low‐shear exposure by four orders of magnitude
Yevgeniy Kreinin, Mark Epshtein, Yahel Talmon, Tirosh Mekler, Itay Or, Mahli Raad, Gil Bolotin, Josué Sznitman, Netanel Korin   +8 more
wiley   +1 more source

Blood flow restriction reduces the increases in cardiorespiratory responses and subjective burden without inhibiting muscular activity during cycling at ventilatory threshold in healthy males. [PDF]

PLoS One, 2023
Uematsu A, Mizushima Y, Ishizaka H, Hortobágyi T, Mizushima T, Toyoda S, Nakajima T.   +6 more
europepmc   +1 more source

Safety of Sodium‐Ion Batteries: Evaluation and Perspective from Component Materials to Cells, Modules, and Packs

Advanced Energy Materials, EarlyView.
This review provides a bottom‐up evaluation of sodium‐ion battery safety, linking material degradation mechanisms, cell engineering parameters, and module/pack assembly. It emphasizes that understanding intrinsic material stability and establishing coordinated engineering control across hierarchical levels are vital for preventing degradation coupling ...
Won‐Gwang Lim, Seoa Kim, Erik A. Wu, Darren H. S. Tan, Shawn Peng, Xiaolin Li   +5 more
wiley   +1 more source