Results 81 to 90 of about 778,421 (286)

Conditionally Significant eQTL and TWAS Analyses Identify MsRD26 as a Major Candidate Positive Regulator of Salt Tolerance in Medicago sativa L

Advanced Science, EarlyView.
Salt stress significantly impacts plant growth. Through population transcriptome, eQTL and TWAS analyses, we identified several candidate genes potentially associated with salt stress response. Functional assays suggested that some of these genes may contribute to salt tolerance.
Lin Chen, Yuqi Zhang, Xinyue Ma, Jinpeng Bi, Fei He, Li Zhao, Haiyue Lei, Zhengqin Xiao, Xue Wang, Tiejun Zhang, Ruicai Long, Junmei Kang, Qingchuan Yang   +12 more
wiley   +1 more source

Nucleoside‐Modified mRNA Encoding Alpha‐Galactosidase A Ameliorates Fabry Disease Phenotypes in Human IPSC‐Derived Cardiomyocytes

Advanced Science, EarlyView.
Human iPSC‐derived Fabry cardiomyocytes exhibited broad transcriptional dysregulation, apoptosis, mitochondrial dysfunction, impaired reactive oxygen species handling, altered contractility, and abnormal calcium transient decay, potentially mediated by phospholamban hyperphosphorylation.
Malte Juchem, Lea Oehlsen, Sedef Ersoy, Jia Li Ye, Natalie Weber, Elisa Mohr, Wilson Agyapong, Junqing Liu, Maximilian Fuchs, Ke Xiao, Christopher Jahn, Reto Eggenschwiler, Tobias Cantz, Julia Beimdiek, Falk F. R. Buettner, Theresia Kraft, Jan Hegermann, Ivonne J. Knorr, Lisa Ernst, Linda Feldbrügge, Resa Puffert, Kevin Schmidt, Christian Bär, Jeannine Hoepfner, Thomas Thum   +24 more
wiley   +1 more source

A Biofabricated Human Acinus‐on‐a‐Chip Unveils Mechanotransductive Drivers of Ventilator‐Induced Lung Injury via Decoupling Volutrauma and Barotrauma

Advanced Science, EarlyView.
This bioinspired acinus‐on‐a‐chip recapitulates VILI pathology, revealing that volutrauma drives P53/NF‐κB pathways while barotrauma triggers mitochondrial‐Wnt dysregulation. A fibrotic transitional cell cluster was identified. Pharmacological interventions targeting these pathways significantly ameliorated injury, establishing a mechanobiological ...
Heng Lu, Liansheng Liu, Zengyong Hu, Shuxian Fang, Ruohan Ren, Sidi Liu, Meng Zhao, Zhiting Luo, Ziyue Zhang, Wenlong Shao, Qian Liu   +10 more
wiley   +1 more source

Peak Oxygen Uptake Prediction From Resting and Submaximal Variables of Cardiopulmonary Exercise Testing

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Cardiorespiratory fitness, as measured by peak oxygen uptake during cardiopulmonary exercise testing, is a prognostic indicator. We aim to predict peak oxygen uptake from submaximal variables on cardiopulmonary exercise testing to assess ...
Yonghun Lee, Jeffrey Feng, Al Rahrooh, Alex A. T. Bui, Christopher B. Cooper, Jeffrey J. Hsu   +5 more
doaj   +1 more source

SerpinA3 is an Endogenous TGF‐β Receptor Antagonist that Attenuates Cardiac Fibroblast Activation and Fibrotic Remodeling

Advanced Science, EarlyView.
SerpinA3 acts as an endogenous TGF‐β receptor antagonist that binds to the extracellular domain of TGFR‐1, thereby preventing TGFR‐1–TGFR‐2 complex formation. This receptor‐level blockade suppresses TGF‐β/Smad2/3 signaling, attenuates cardiac fibroblast activation, and extracellular matrix deposition, and ultimately alleviates pressure overload–induced
Hui Wang, Jieyu Cui, Chunlu Huang, Wanyi Guo, Tong Liu, Yi Zhu, Shuai Shao, Kangyin Chen, Jinlong He, Qiankun Bao   +9 more
wiley   +1 more source

Agreement between heart rate variability‐derived and lactate/ventilatory thresholds during a 4‐min stepwise incremental cycling test in male adults

Physiological Reports
Accurate exercise intensity thresholds are key for endurance training prescription. The non‐linear heart rate (HR) variability (HRV) index DFAa1 has been proposed as a threshold determination marker, with DFAa1 values of 0.75 (HRVT1) and 0.5 (HRVT2 ...
Anton Olieslagers, Yoram Müller‐Jabusch, Margot Vancoillie, Emma Delen, Toon de Beukelaar   +4 more
doaj   +1 more source

Heart rate deflection point as an alternative to determining the anaerobic threshold in dyslipidaemic patients

Motriz: Revista de Educacao Fisica, 2019
Aim: The aim of the present study was to verify the agreement between the ventilatory method (VT) and the alternative method of heart rate deflection point (HRDP) in determining the anaerobic threshold (AT) during incremental treadmill test in ...
Rochelle Rocha Costa, Thais Reichert, Bruna Machado Barroso, Vitória de Mello Bones da Rocha, Artur Avelino Birk Preissler, Éder Santiago, Eli Gonçalves Junior, Danielle Girolometto Fracalossi, Rodrigo Sudatti Delevatti, Luiz Fernando Martins Kruel   +9 more
doaj   +1 more source

Ventilatory Threshold and Risk of Pulmonary Exacerbations in Cystic Fibrosis. [PDF]

Respir Care, 2023
Campos NE, Vendrusculo FM, Pérez-Ruiz M, Donadio MVF.   +3 more
europepmc   +1 more source

Bridging Horizontal to Vertical Radiative Cooling

Advanced Science, EarlyView.
Radiative cooling materials are mature but only work facing the sky, confining them to rooftops. Instead of developing new ones, this system bridges existing horizontal coolers to vertical windows using blades outside the glass. On an occupied urban building, windows stay up to 1.4°C below air temperature while preserving daylight, outward views, and ...
Xiangyu Meng, Gan Huang
wiley   +1 more source

The effect of ventilatory threshold in endurance and resistance training

PURPOSE: With the growing rate of physical inactivity in the United States and around the world, the study of how to improve performance and increase the health benefits that come with exercise is increasing.
Shackelford, Hunter
core   +1 more source