Results 51 to 60 of about 140,852 (310)
Molecular Oncology, EarlyView.This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns +10 more
wiley +1 more source
Device removes hydrogen gas from enclosed spaces [PDF]
, 1966 Hydrogen-oxidant galvanic cell removes small amounts of hydrogen gas continually released from equipment, such as vented silver-zinc batteries, in enclosed compartments where air venting is not feasible.
Carson, W. N.
core +1 more source
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
Li-Ion Battery Fire Hazards and Safety Strategies
Energies, 2018 In the past five years, there have been numerous cases of Li-ion battery fires and explosions, resulting in property damage and bodily injuries. This paper discusses the thermal runaway mechanism and presents various thermal runaway mitigation approaches,
Lingxi Kong +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Fill and vent quick disconnect [PDF]
, 1972 Hydraulic disconnect coupling on ground serving half of spacecraft refrigeration cooling system employs movable center stem for venting and closing nipple poppet.
Boerner, R. Y., Hedrick, R. W.
core +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Oman Journal of Ophthalmology, 2018 PURPOSE: To evaluate the impact of venting incision on graft detachment in Descemet stripping automated endothelial keratoplasty (DSAEK). MATERIALS AND METHODS: Retrospective comparative study on DSAEK procedure performed with (n = 13) and without (n ...
Namrata Kabra +2 more
doaj +1 more source
Two-fluid, impinging-sheet injector [PDF]
, 1968 Two-fluid, impinging-sheet propellant injector reduces the severe erosion found to occur when ejector elements are directly exposed during throttling without the benefits of a cooling flow of the propellant liquids.
Riebling, R. W.
core +1 more source