Results 161 to 170 of about 104,006 (269)

Ventral striatum dopamine release encodes unique properties of visual stimuli in mice. [PDF]

Elife, 2023
Gonzalez LS, Fisher AA, D'Souza SP, Cotella EM, Lang RA, Robinson JE.   +5 more
europepmc   +1 more source

Matsupexole: A novel nonergot dopamine receptor agonist with sustained efficacy in a rat model of Parkinson's disease and limited off‐target activity

British Journal of Pharmacology, EarlyView.
Background and Purpose Dopamine receptor agonists, particularly targeting the dopamine D2L receptor (D2LR), have been used to treat Parkinson's disease (PD). However, valvular heart disease and somnolence, mainly caused by activating the serotonin 5‐HT2B receptor (5‐HT2BR) and dopamine D3 receptor (D3R), respectively, currently challenge their clinical
Takayuki Suzuki, Fumiki Oana, Masaki Oota, Yuma Handa, Osamu Kaminuma   +4 more
wiley   +1 more source

Restoring failed inhibition in the substantia nigra pars reticulata suppresses absence seizures in rats

Epilepsia, EarlyView.
Abstract Objective For over four decades, the substantia nigra pars reticulata (SNr) has been recognized as a critical structure in the modulation of seizure activity. Pharmacological and optogenetic inhibition of the SNr produces robust seizure suppression in a range of seizure models.
Devin Palmer, Patrick A. Forcelli
wiley   +1 more source

Biased thalamic innervation onto the distinct subregion where dopamine receptor 1 is dominantly expressed in the caudal striatum

Neuroscience Research
In the ventral part of the caudal striatum, the direct and indirect pathway neurons are unevenly distributed, forming zones with a paucity of neurons with dopamine receptor 1 (D1R) or dopamine receptor 2 (D2R), referred as D1R- or D2R-poor zone (D1pz or ...
Fuko Kadono, Jingqi Wang, Kenta Kobayashi, Fuyuki Karube, Fumino Fujiyama   +4 more
doaj   +1 more source

Distinct roles of the orbitofrontal cortex, ventral striatum, and dopamine neurons in counterfactual thinking of decision outcomes. [PDF]

Sci Adv, 2023
Yun M, Nejime M, Kawai T, Kunimatsu J, Yamada H, Kim HR, Matsumoto M.   +6 more
europepmc   +1 more source

Annual Research Review: What processes are dysregulated among emotionally dysregulated youth? – a systematic review

Journal of Child Psychology and Psychiatry, Volume 66, Issue 4, Page 516-546, April 2025.
Proliferation of the term “emotion dysregulation” in child psychopathology parallels the growing interest in processes that influence negative emotional reactivity. While it commonly refers to a clinical phenotype where intense anger leads to behavioral dyscontrol, the term implies etiology because anything that is dysregulated requires an impaired ...
Joseph C. Blader, Amy S. Garrett, Steven R. Pliszka   +2 more
wiley   +1 more source

Resting-State Functional Connectivity of the Dorsal and Ventral Striatum, Impulsivity, and Severity of Use in Recently Abstinent Cocaine-Dependent Individuals. [PDF]

Int J Neuropsychopharmacol, 2023
Dong X, Zhornitsky S, Wang W, Le TM, Chen Y, Chaudhary S, Li CR, Zhang S.   +7 more
europepmc   +1 more source

Annual Research Review: Neural mechanisms of eating disorders in youth – from current theory and findings to future directions

Journal of Child Psychology and Psychiatry, EarlyView.
Eating disorders are prevalent and profoundly debilitating psychiatric conditions with multifactorial etiology that frequently manifest during adolescence. This developmental stage is characterized by significant neurostructural and neurofunctional change, which may create a context conducive to the emergence of eating pathology.
Kelsey Hagan, E. Caitlin Lloyd, Sasha Gorrell   +2 more
wiley   +1 more source

Annual Research Review: Early conduct problems – precursors, outcomes, and etiology

Journal of Child Psychology and Psychiatry, EarlyView.
During the toddler and preschool period, nearly all children engage in some level of aggression, defiance, stealing, and temper tantrums. While the frequency and intensity of these behaviors tends to decrease across early childhood, a subset of children engage in these conduct problem behaviors at a higher intensity early in life and/or do not desist ...
Luke W. Hyde, Christopher J. Trentacosta, Jessica L. Bezek   +2 more
wiley   +1 more source

Elevated neurofilament light levels in acute anorexia nervosa are associated with alterations in white matter volume and connectivity networks

Journal of Child Psychology and Psychiatry, EarlyView.
Background Anorexia nervosa (AN) is a severe eating disorder associated with drastic reductions in gray and white matter (WM) volume and structural connectivity alterations. However, the hypotheses regarding underlying mechanisms are inconclusive. The current study investigated the relationships of WM volume as well as WM network architecture with ...
Inger Hellerhoff, Daniel Geisler, Fabio Bernardoni, Arne Doose, Friederike I. Tam, David M. Poitz, Nina Chotjewitz, Veit Roessner, Katja Akgün, Tjalf Ziemssen, Stefan Ehrlich   +10 more
wiley   +1 more source