Results 211 to 220 of about 313,250 (274)

LF-DBS of the ventral striatum shortens persistence for morphine place preference and modulates BDNF expression in the hippocampus. [PDF]

Behav Brain Res
Lloret-Torres ME, Barreto-Estrada JL.
europepmc   +1 more source

Serotonin engages divergent 5‐HT receptor pathways for cell type‐resolved modulation of prefrontal layer 5 microcircuits

British Journal of Pharmacology, Volume 183, Issue 19, Page 5832-5853, October 2026.
Serotonin differentially modulates layer 5 mPFC microcircuits through cell type‐specific pre‐ and postsynaptic receptor pathways. Presynaptic 5‐HT1BRs suppress glutamate and GABA release, whereas presynaptic and postsynaptic 5‐HT3ARs enhance fast‐spiking interneuron activity, whilst distinct pyramidal neuron subtypes exhibit divergent 5‐HT1AR‐ and 5 ...
Ramya Rama, Guanxiao Qi, Gabriele Radnikow, Danqing Yang, Dirk Feldmeyer   +4 more
wiley   +1 more source

Muscarinic agonists for schizophrenia: Bridging preclinical evidence and clinical enthusiasm

British Journal of Pharmacology, Volume 183, Issue 19, Page 5701-5731, October 2026.
Abstract Antipsychotic drugs targeting dopamine receptors have been used to treat schizophrenia for decades, primarily alleviating positive symptoms such as hallucinations and delusions. However, they provide limited benefit for cognitive and negative symptoms—major contributors to poor outcomes—and are frequently associated with significant side ...
Brian J. Morris, Judith A. Pratt
wiley   +1 more source

Down-modulation of functional ventral striatum activation for emotional face stimuli in patients with insula damage. [PDF]

PLoS One
K K, M D, B VS, A L, M L.
europepmc   +1 more source

Insular cortex to ventral striatum synapses encode valence of social interaction

, 2022
Bellone C, Espinosa P, Girard B, Lucchini M, Campanelli F, Tiriticco V.   +5 more
europepmc   +1 more source

The Role of Kappa‐Opioid Receptor/Dynorphin System in Modulating Neural‐Circuits of Depression and Anxiety—A Review

Journal of Cellular and Molecular Medicine, Volume 30, Issue 19, October 2026.
ABSTRACT Major depression and anxiety disorders are psychiatric disorders that involve a great number of people. There is a growing need for new and better pharmacological treatments for these diseases. Kappa‐opioid receptor (KOR) antagonists seem to be a promising new pathway for the development of new antidepressants and anxiolytics, but a great ...
Cristian Ciotei, Horia Păunescu, Cristina Lungu, Adriana‐Alexandra Marica, Mihai Florin Tănase, Ruxandra‐Cristina Marin, Mihnea Costescu, Ion Fulga, Oana Andreia Coman   +8 more
wiley   +1 more source

Direct Pathway Neurons in the Mouse Ventral Striatum Are Active During Goal-Directed Action but Not Reward Consumption During Operant Conditioning. [PDF]

Biomedicines
Cataldi S, Lacefield C, Shashaank N, Sulzer D.   +3 more
europepmc   +1 more source

Increased Expression of α‐Synuclein Impairs Trafficking of the Essential SNARE Protein Synaptobrevin‐2

Journal of Neurochemistry, Volume 170, Issue 10, October 2026.
α‐Synuclein is a presynaptic protein extensively studied for its role in Parkinson's disease; however, its native function remains unclear. Here, we show that modest (approximately 2‐fold) overexpression of α‐synuclein in cultured neurons, at levels observed in familial synucleinopathies with SNCA triplication, impairs the endocytic retrieval of the ...
Elyas H. Arvell, James P. Carroll, Joshua Saito, Holly Melland, Ranjith R. Unnithan, Chris French, Danny M. Hatters, Sarah L. Gordon   +7 more
wiley   +1 more source

Motor System-Dependent Effects of Amygdala and Ventral Striatum Lesions on Explore-Exploit Behaviors. [PDF]

J Neurosci
Giarrocco F, Costa VD, Basile BM, Pujara MS, Murray EA, Averbeck BB.   +5 more
europepmc   +1 more source

Estrogen/Esr2b signaling‐dependent, female‐biased expression of a neuropeptide Y gene in the medaka brain

Journal of Neuroendocrinology, Volume 38, Issue 10, October 2026.
Abstract A recent study showed that female medaka lacking the estrogen receptor gene esr2b are unreceptive to male courtship and instead court other females. In this study, we investigated the brain transcriptome of esr2b‐deficient females to explore the underlying mechanisms of this behavioral phenotype, and identified npyb, one of the two ...
Yuki Homan, Yuji Nishiike, Mika Sato‐Tsukamoto, Daisuke Saito, Mikita Suyama, Yasuyuki Ohkawa, Fumiya Takahashi, Takashi Baba, Ken‐ichirou Morohashi, Kataaki Okubo   +9 more
wiley   +1 more source