Parkinson's Disease, 2011 Cognitive abnormalities are a feature of Parkinson's disease (PD). Unlike motor symptoms that are clearly improved by dopaminergic therapy, the effect of dopamine replacement on cognition seems paradoxical.
Penny A. MacDonald, Oury Monchi
doaj +1 more source
A Mechanism Linking Two Known Vulnerability Factors for Alcohol Abuse: Heightened Alcohol Stimulation and Low Striatal Dopamine D2 Receptors [PDF]
, 2019 Alcohol produces both stimulant and sedative effects in humans and rodents. In humans, alcohol abuse disorder is associated with a higher stimulant and lower sedative responses to alcohol.
Bocarsly, Miriam E. +8 more
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Why we interact : on the functional role of the striatum in the subjective experience of social interaction [PDF]
, 2014 Acknowledgments We thank Neil Macrae and Axel Cleeremans for comments on earlier versions of this manuscript. Furthermore, we are grateful to Dorothé Krug and Barbara Elghahwagi for their assistance in data acquisition.
Bente, Gary +6 more
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Aversive event anticipation affects connectivity between the ventral striatum and the orbitofrontal cortex in an fMRI avoidance task. [PDF]
PLoS ONE, 2013 Ability to anticipate aversive events is important for avoiding dangerous or unpleasant situations. The motivation to avoid an event is influenced by the incentive salience of an event-predicting cue. In an avoidance fMRI task we used tone intensities to
Ingeborg Bolstad +5 more
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Deep Brain Stimulation of the Ventral Capsule/Ventral Striatum for Treatment-Resistant Depression [PDF]
Biological Psychiatry, 2009 We investigated the use of deep brain stimulation (DBS) of the ventral capsule/ventral striatum (VC/VS) for treatment refractory depression.Fifteen patients with chronic, severe, highly refractory depression received open-label DBS at three collaborating clinical sites. Electrodes were implanted bilaterally in the VC/VS region. Stimulation was titrated
Donald A, Malone +17 more
openaire +2 more sources
The Effects of Acute Stress Exposure on Neural Correlates of Pavlovian Conditioning with Monetary Gains and Losses [PDF]
, 2014 Pavlovian conditioning involves the association of an inherently neutral stimulus with an appetitive or aversive outcome, such that the neutral stimulus itself acquires reinforcing properties.
Delgado, Mauricio R. +2 more
core +3 more sources
Disrupted reinforcement learning during post-error slowing in ADHD.
PLoS ONE, 2019 ADHD is associated with altered dopamine regulated reinforcement learning on prediction errors. Despite evidence of categorically altered error processing in ADHD, neuroimaging advances have largely investigated models of normal reinforcement learning in
Andre Chevrier +5 more
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The neurobiology of reference-dependent value computation [PDF]
, 2009 A key focus of current research in neuroeconomics concerns how the human brain computes value. Although, value has generally been viewed as an absolute measure (e.g., expected value, reward magnitude), much evidence suggests that value is more often ...
De Martino, Benedetto +3 more
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Roles for the Dorsal Striatum in Aversive Behavior
Frontiers in Cellular Neuroscience, 2021 The ability to identify and avoid environmental stimuli that signal danger is essential to survival. Our understanding of how the brain encodes aversive behaviors has been primarily focused on roles for the amygdala, hippocampus (HIPP), prefrontal cortex,
Adrien T. Stanley +4 more
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Frontiers in Systems Neuroscience, 2017 Within the striatum, cholinergic interneurons, electrophysiologically identified as tonically active neurons (TANs), represent a relatively homogeneous group in terms of their functional properties.
Kevin Marche +2 more
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