Results 81 to 90 of about 313,250 (274)

Interval timing and time-based decision making requires differential protein synthesis in the dorsal and ventral striatum for the setting of ‘Start’ and ‘Stop’ response thresholds

Frontiers in Integrative Neuroscience, 2012
Time-based decision-making in peak-interval timing procedures involves the setting of response thresholds for the initiation (‘Start’) and termination (‘Stop’) of a response sequence that is centered on the target duration.
Christopher eMacDonald, Ruey-Kuang eCheng, Warren H Meck   +2 more
doaj   +1 more source

Dopamine regulates spine density in striatal projection neurons in a concentration-dependent manner

Neurobiology of Disease, 2020
Dopaminergic afferents innervate spiny projection neurons (SPNs) in the striatum, maintaining basal ganglia activity. The loss of striatal innervation is the hallmark of Parkinson's disease (PD), which is characterized by dopaminergic denervation. A lack
Samuel Alberquilla, Aldo Gonzalez-Granillo, Eduardo Daniel Martín, Rosario Moratalla   +3 more
doaj   +1 more source

The Neural Responses to Social Cooperation in Gain and Loss Context. [PDF]

PLoS ONE, 2016
Cooperation is pervasive and constitutes the core behavioral principle of human social life. Previous studies have revealed that mutual cooperation was reliably correlated with two reward-related brain regions, the ventral striatum and the orbitofrontal ...
Peng Sun, Li Zheng, Lin Li, Xiuyan Guo, Weidong Zhang, Yijie Zheng   +5 more
doaj   +1 more source

Predictors of Hypomania During Ventral Capsule/Ventral Striatum Deep Brain Stimulation [PDF]

The Journal of Neuropsychiatry and Clinical Neurosciences, 2016
Deep brain stimulation (DBS) of the ventral capsule/ventral striatum (VC/VS) is a novel therapy for neuropsychiatric disorders. Hypomania is a known complication of VC/VS DBS, but who is at risk is less understood. Factors such as family history, combined with details of DBS programming, might quantify that risk.
Alik S, Widge, Ernesto, Licon, Samuel, Zorowitz, Andrew, Corse, Amanda R, Arulpragasam, Joan A, Camprodon, Cristina, Cusin, Emad N, Eskandar, Thilo, Deckersbach, Darin D, Dougherty   +9 more
openaire   +2 more sources

Predictive Neural Coding of Reward Preference Involves Dissociable Responses in Human Ventral Midbrain and Ventral Striatum [PDF]

, 2005
SummaryFood preferences are acquired through experience and can exert strong influence on choice behavior. In order to choose which food to consume, it is necessary to maintain a predictive representation of the subjective value of the associated food ...
O'Doherty, JP, Dolan, RJ, Buchanan, TW, Dolan, R. ; https://orcid.org/, Seymour, B., ,, Buchanan, T., Buchanan, Tony W., Dolan, Raymond J., O'Doherty, John P., Seymour, B, Seymour, Ben, O'Doherty, J.   +12 more
core   +1 more source

PLOD1 Catalytic Activity Stabilizes ENO1 by Limiting FBXW7‐dependent Degradation to Promote Glycolysis and TMZ Resistance in Glioblastoma

Advanced Science, EarlyView.
PLOD1 interacts with ENO1 and limits its FBXW7‐dependent ubiquitination and proteasomal degradation through a mechanism requiring PLOD1 catalytic activity. ENO1 stabilization sustains glycolysis, promoting glioblastoma cell proliferation, migration, and temozolomide resistance.
Fen Xue, Dingkong Liang, Xin Chen, Fei Fan, Xiayun He   +4 more
wiley   +1 more source

Cognitive Outcome After Deep Brain Stimulation for Refractory Obsessive–Compulsive Disorder: A Systematic Review

Neuromodulation: Technology at the Neural Interface, EarlyView., 2021
Abstract Introduction Deep brain stimulation (DBS) is an effective treatment for refractory obsessive–compulsive disorder (OCD). Neuropsychological assessment contributes to DBS treatment in several ways: it monitors the cognitive safety of the treatment, identifies beneficial or detrimental cognitive side effects and it could aid to explain ...
Tim A. M. Bouwens van der Vlis, Annelien Duits, Mégan M. G. H. van de Veerdonk, Anne E. P. Mulders, Koen R. J. Schruers, Yasin Temel, Linda Ackermans, Albert F. G. Leentjens   +7 more
wiley   +1 more source

KIF1A‐Mediated Axonal Transport of Netrin‐1 in iPSC‐Derived Human Forebrain Neurons

Cytoskeleton, EarlyView.
ABSTRACT Netrin‐1 is a secreted laminin‐like protein that functions as a guidance cue for axon pathfinding in development. Netrin‐1 also modulates synapse formation in developing neurons and long‐term potentiation in mature neurons. Netrin‐1 is expressed in human neurons; however, its intracellular distribution and trafficking have not been assessed ...
T. Y. Leung, J. Sidhu, A. Hsieh, Y. Ma, J. Liu, M. A. Silverman   +5 more
wiley   +1 more source

Direct Activation of the Ventral Striatum in Anticipation of Aversive Stimuli [PDF]

, 2003
The brain “reward” system, centered on the limbic ventral striatum, plays a critical role in the response to pleasure and pain. The ventral striatum is activated in animal and human studies during anticipation of appetitive/pleasurable events, but its ...
Kapur, S, Crawley, A P, Mikulis, D J, McIntosh, Anthony R, McIntosh, A R, Crawley, Adrian P, Remington, G, Jensen, Jimmy, Jensen, J, Remington, Gary, Mikulis, David J, Kapur, Shitij   +11 more
core   +1 more source

Do Brain Extracellular Fluid Concentrations Predict PET‐Inferred Receptor Occupancy in Human CNS? A Mechanistic Model‐Based Analysis of Dopamine D2 Receptor Ligands

Clinical Pharmacology &Therapeutics, EarlyView.
A mechanistic CNS PBPK model framework was applied to eight antipsychotic D2 receptor ligands, comparing brain extracellular fluid (brainECF) and brain cell membrane (brainM) as biophase for predicting human receptor occupancy compared against PET neuroimaging data. BrainM concentrations showed improved agreement with PET‐derived receptor occupancy for
Divakar Budda, J.G. Coen van Hasselt, Elizabeth C.M. de Lange   +2 more
wiley   +1 more source