Results 221 to 230 of about 1,029,845 (331)

Accelerating virtual patient generation with a Bayesian optimization and machine learning surrogate model

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 486-494, March 2025.
Abstract The pharmaceutical industry has increasingly adopted model‐informed drug discovery and development (MID3) to enhance productivity in drug discovery and development. Quantitative systems pharmacology (QSP), which integrates drug action mechanisms and disease complexities to predict clinical endpoints and biomarkers is central to MID3.
Hiroaki Iwata, Ryuta Saito
wiley   +1 more source

Percutaneous Epicardial Ablation of Ventricular Arrhythmias Arising From the Left Ventricular Summit: Outcomes and Electrocardiogram Correlates of Success

Circulation: Arrhythmia and Electrophysiology, 2015
P. Santangeli, F. Marchlinski, Erica S. Zado, Daniel Benhayon, M. Hutchinson, D. Lin, D. Frankel, Michael P. Riley, G. Supple, Fermin C. García, R. Bala, B. Desjardins, D. Callans, S. Dixit   +13 more
semanticscholar   +1 more source

Ashwagandha: Is It Safe? Part 2: A Preclinical Evidence Review

Phytotherapy Research, EarlyView.
ABSTRACT The preclinical evidence for the safety of ashwagandha (Withania somnifera (L.) Dunal, AS) is reviewed, and its preparations (extracts) and constituents, from the general toxicity in animal models to in vitro and cell culture studies, which may elucidate mechanisms of action and explain clinical case reports.
Elizabeth M. Williamson, Thomas Brendler
wiley   +1 more source

Long-term outcome of catheter ablation of left fascicular ventricular arrhythmias. [PDF]

J Interv Card Electrophysiol
My I, Moser F, Loeck FW, Obergassel J, Rottner L, Lemoine MD, Kirchhof P, Steven D, Sultan A, Willems S, Meyer C, Reissmann B, Rillig A, Metzner A, Ouyang F.   +14 more
europepmc   +1 more source

Mechanisms of ventricular arrhythmias: from molecular fluctuations to electrical turbulence.

Annual Review of Physiology, 2015
Z. Qu, J. Weiss
semanticscholar   +1 more source

Role of novel automated methods in pulse signal analysis to screen for sleep‐disordered breathing among patients on chronotropic medications

Sleep Research, EarlyView.
Abstract Study objectives To investigate the use of automated analysis to detect heart rate accelerations (HRAs) to screen for sleep‐disordered breathing (SDB) among patients who use chronotropic medications. Methods Nocturnal polysomnography (NPSG) recordings from 933 participants in the Sleep Heart Health Study were analyzed using an automated method
Nabila Ahmed, Moustafa Habra, Raya Nashef, Scott Maresh, Abed Najjar, Shivapriya Chandu, Adhithi Athikumar, Omar Ismail, Laurel A. Ravelo, Paul E. Peppard, M. Safwan Badr, Abdulghani Sankari   +11 more
wiley   +1 more source

Preclinical Toxicity Screening of Sodium Dodecanoyloxybenzenesulfonate (LOBS) as a New Alternative Biocide Using In Vitro and In Vivo Models

Environmental Toxicology, EarlyView.
ABSTRACT Sodium hypochlorite is a well‐established biocide extensively used in both living and industrial environments; however, exposure to it or improper handling can harm the human body and the environment. Thus, safer alternatives to sodium hypochlorite are required.
Seung Eui Min, Seunghee Oh, Min Seong Jang, Kang‐Hyun Han   +3 more
wiley   +1 more source

Stellate ganglion modulation: An old therapy with a new twist for treatment of ventricular arrhythmias. [PDF]

Indian Pacing Electrophysiol J
Avasthi S, Vaseghi M.
europepmc   +1 more source

Perspective: a dynamics-based classification of ventricular arrhythmias.

Journal of Molecular and Cellular Cardiology, 2015
J. Weiss, A. Garfinkel, H. Karagueuzian, T. Nguyen, R. Olcese, Peng-Sheng Chen, Z. Qu   +6 more
semanticscholar   +1 more source