Results 191 to 200 of about 373,905 (314)

SpaMode: A Broadly Applicable Framework for Deciphering Spatial Multi‐Omics Using Multimodal Mixture of Disentangled Experts

Advanced Science, EarlyView.
SpaMode introduces a versatile framework for spatial multi‐omics integration across vertical, horizontal, and mosaic scenarios. By disentangling modality‐invariant and variant features through a mixture‐of‐experts mechanism, it adaptively reconfigures spatially heterogeneous signals.
Xubin Zheng, Xinlei Huang, Xiang Zhou, Dian Meng, Ziyue Qiao, Zhiyuan Yuan, Lixin Cheng   +6 more
wiley   +1 more source

Novel compound heterozygous mutations in <i>KLHL24</i>-induced recessive inherited hypertrophic cardiomyopathy: a case report. [PDF]

Front Cardiovasc Med
Zhou W, Wang X, Yang J, Liao Y.
europepmc   +1 more source

CK2α Deficiency Drives Myocardial Fibrosis via Desmin‐Induced Mitochondrial Dysfunction

Advanced Science, EarlyView.
CK2α preserves mitochondrial homeostasis by phosphorylating Desmin to recruit Cryab, ensuring proper filament assembly. CK2α deficiency disrupts this interaction, causing mitochondrial dysfunction, metabolic shifts, bioenergetic failure, and oxidative stress—ultimately establishing a pro‐fibrotic environment that drives cardiac fibrosis.
Canjie Ma, Jiali Jia, Juncong Lan, Jing Wang, Dan Rao, Lanlan Rao, Weibin Zhang, Dongpeng Wu, Jie Zhang, Gang Wang, Baohua Liu, Ying Ao, Zimei Wang   +12 more
wiley   +1 more source

Recurrent Takotsubo Syndrome and Pulmonary Embolism Revealing a Pheochromocytoma: A Diagnostic Pitfall. [PDF]

Cureus
Said IsmaIl AA, Moyambi J, Arous S, Drighil A, Meftout B.   +4 more
europepmc   +1 more source

Brown Adipocyte Sheets Alleviate Myocardial Ischemia–Reperfusion Injury Through NRG4–ErbB4–Dependent Ferroptosis Inhibition

Advanced Science, EarlyView.
Brown adipocyte sheets are engineered to protect the heart against myocardial ischemia–reperfusion injury by restraining ferroptosis. Upon transplantation onto the cardiac surface, they improve cardiac function, limit infarction and fibrosis, and enhance angiogenesis.
Lifu Sun, Yuting Liu, Jingbo Zhang, Takuji Kawamura, Junjun Li, Li Liu, Shigeru Miyagawa   +6 more
wiley   +1 more source

Sinus Node Dysfunction in Takotsubo Syndrome: An Uncommon Presentation. [PDF]

JACC Case Rep
Zakynthinos GE, Kalogeras K, Vlachojannis GJ, Makavos G, Kokkinos NK, Souvaliotis N, Katsianos E, Vythoulkas-Biotis N, Dilaveris P, Siasos G.   +9 more
europepmc   +1 more source

STAID: A Self‐Refining Deep Learning Framework for Spatial Cell‐Type Deconvolution with Biologically Informed Modeling

Advanced Science, EarlyView.
STAID is a unified deep learning framework that couples iterative pseudo‐spot refinement with neural network training through a feedback loop and exploits gene co‐expression information to model higher‐order interactions, achieving accurate and robust cell‐type deconvolution in spatial transcriptomics.
Jixin Liu, Shuli Sun, Zhengliang Lv, Xinyu Liu, Yihua Wang, Bingqiang Liu   +5 more
wiley   +1 more source

Effects of Metabolic Factors on Left Ventricular Diastolic Function in Patients with Obstructive Sleep Apnea

Yi-Fan Zhou,1,* Shu-Han Chen,1,* Wan-Da Wang,1 Jia-Le Chen,1 Ping-Yu Cai,1 Mei-Mei Li,1 Yue-Ling Lin,1 Wan-Qi Li,1 De-Hong Huang,1 Jun Li,1 Yue-Ting Li,2 Hui-Li Lin1 1Department of Cardiology, The Second Affiliated Hospital of Fujian Medical ...
Li YT, Li WQ, Zhou YF, Li J, Cai PY, Huang DH, Lin YL, Lin HL, Wang WD, Chen SH, Li MM, Chen JL   +11 more
core  

Finerenone combined with guideline-directed medical therapy in patients with post-myocardial infarction heart failure: a real-world study. [PDF]

Front Pharmacol
Zhao D, Xia J, Yang Z, Yong Y, Wang L, Liu J.   +5 more
europepmc   +1 more source

Topologically Structured PLLA Fibers With Stress Concentration Effects for Health Monitoring

Advanced Science, EarlyView.
In this study, a multi‐path strategy was developed to enhance the piezoelectric properties of PLLA fibers through the stress concentration effect. The optimized devices generate piezoelectric output up to 14 times that of pure PLLA fibers. This piezoelectric enhancement strategy offers a new approach for high‐performance piezoelectric devices, with ...
Longfei Li, Juwei Yang, Yiqian Wang, Qiao Yu, Zhenmin Fan, Chang Zhu, Ming Yin, Wei Hua, Zhou Li   +8 more
wiley   +1 more source