Results 211 to 220 of about 8,670,383 (247)

Cardiac Endothelial Enhancer RNA Tek‐e1 Restores Microvascular Homeostasis After Myocardial Infarction

open access: yesAdvanced Science, EarlyView.
Hypoxia‐induced KDM5A downregulation establishes a distinct endothelial repair programme, increasing H3K4me3 at the Tek promoter and intronic enhancer, enabling ISL1 to coordinately activate Tek transcription and induce enhancer‐RNA Tek‐e1. This cis‐regulatory RNA is essential for additional Tek/TIE2 induction through R‐loop formation and reinforced ...
Yang Lyu   +19 more
wiley   +1 more source

Acute Afterload Stress Induced by Phenylephrine Administration Reveals Ventricular Dysfunction in Myocardial Infarcted Female Rats Previously Exposed to Cigarette Smoke. [PDF]

open access: yesBiomedicines
Bocalini DS   +8 more
europepmc   +1 more source

SynAtlas: A Safe and Versatile Platform for Rapid Organ‐Scale Tissue Clearing and 3D Atlas Mapping

open access: yesAdvanced Science, EarlyView.
An orthogonal synergy design principle integrates lipid solubilization, protein hydration modulation, and refractive‐index matching within a unified aqueous clearing system. This modular strategy enables rapid, low‐hazard, and broadly compatible tissue clearing while preserving molecular signals, supporting multiscale three‐dimensional imaging across ...
Mei‐Xue Yuan   +10 more
wiley   +1 more source

Right Ventricular Dysfunction and Ventriculo-Arterial Uncoupling in Heart Failure With Preserved Ejection Fraction: A Phenotype-Specific Review of Mechanisms, Diagnosis, and Therapeutic Strategies. [PDF]

open access: yesClin Cardiol
Chamoun A   +13 more
europepmc   +1 more source

Targeting a Calcium‐Associated Mitochondrial Vulnerability in TET2‐Deficient Myeloid Cells

open access: yesAdvanced Science, EarlyView.
Reduced TET2 function creates a calcium‐associated mitochondrial vulnerability in macrophages that is preferentially exploited by Lanatoside C. The resulting stress promotes apoptosis of TET2‐deficient macrophages, reduces inflammatory and fibrotic injury in human cardiac organoids, and highlights a genotype‐associated myeloid liability that may be ...
Yue Wang   +18 more
wiley   +1 more source

Correction to: Coronary microvascular function in patients with sepsis and myocardial injury: an invasive coronary physiology study. [PDF]

open access: yesCrit Care
Lörstad S   +12 more
europepmc   +1 more source

A Single Volatile VO2 Memristor Enabling Neuromorphic Perception, Learning, and Computing

open access: yesAdvanced Electronic Materials, EarlyView.
A single volatile VO2 memristor fabricated via atomic layer deposition is demonstrated as a multifunctional neuromorphic device enabled by intrinsic threshold‐switching dynamics. The device reproduces neuron‐like integration and firing, short‐timescale associative learning, temporal ECG pattern classification, and nociceptive responses to electrical ...
Bingkai Ding   +7 more
wiley   +1 more source

First-in-Human Totally Endoscopic Robotic Repair of Cor Triatriatum Sinistrum Under Ventricular Fibrillation. [PDF]

open access: yesJACC Case Rep
Bisleri G   +6 more
europepmc   +1 more source

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