Results 201 to 210 of about 1,105,751 (346)

Mid-Term Functional Recovery after Surgical Correction of ALCAPA: A 16-Year Single-Center Experience. [PDF]

Ann Thorac Cardiovasc Surg
Beyter MB, Dogan E, Tuncer ON, Ergin F, Kayan-Kasikci G, Ulger Z, Levent E, Atay Y.   +7 more
europepmc   +1 more source

DNA Nanoflower LYTACs Enable Efficient VEGF Degradation and Verteporfin Loading for Combined Therapy of Wet Age‐Related Macular Degeneration

Advanced Science, EarlyView.
An integrated approach that combines a DNA nanoflower VEGF degrader with photodynamic therapy is developed for the treatment of wet age‐related macular degeneration, which reduces the risk of VEGF reactivation‐induced CNV recurrence and minimizes the systemic side effects associated with photodynamic therapy.
Mengxuan Li, Yan Yue, Sijin Wu, Xinyu He, Jiayi Song, Shuwen Ma, Haokun Zhang, Chenyu Xu, Song Chen, Yanming Huang, Songbo Xie, Hua Yan   +11 more
wiley   +1 more source

A Screening Method for Determining Left Ventricular Systolic Function Based on Spectral Analysis of a Single-Channel Electrocardiogram Using Machine Learning Algorithms. [PDF]

Diagnostics (Basel)
Kuznetsova N, Suvorov A, Gognieva D, Fashafsha Z, Podgalo D, Mesitskaya D, Shchekochikhin D, Sedov V, Chomakhidze P, Kopylov P.   +9 more
europepmc   +1 more source

Connexin43 Deficiency Leads to Ventricular Arrhythmias by Reprogramming Proline Metabolism

Advanced Science, EarlyView.
The study demonstrated that connexin43 (Cx43) knockout caused arrhythmic phenotype and decreased proline content in vitro and in vivo. Mechanistically, Cx43 interacts with the amino acid transporter SNAT2 (sodium‐dependent neutral amino acid transporter), and its deficiency disrupts proline transport and metabolism.
Hangying Ying, Hangping Fan, Yunhe Wang, Ruhong Jiang, Dongsheng Cai, Hui Cheng, Hao Wang, Chenyang Jiang, Ping Liang   +8 more
wiley   +1 more source

Vericiguat Therapy Is Associated with Reverse Myocardial Remodeling in Chronic Heart Failure with Reduced Ejection Fraction. [PDF]

J Cardiovasc Dev Dis
Bajec T, Žorž N, Ugovšek S, Zemljič G, Cerar A, Frljak S, Okrajšek R, Girandon Sušanj P, Šebeštjen M, Vrtovec B, Poglajen G.   +10 more
europepmc   +1 more source

F‐Box and Leucine‐Rich Repeat Protein 4 (FBXL4) Maintains Sarcomere Integrity and Cardiac Function by Enhancing K48‐Linked Ubiquitinated Degradation of Profilin‐1 (PFN1)

Advanced Science, EarlyView.
Schematic diagram depicting the proposed signaling mechanisms underlying the effects of FBXL4 in the setting of cardiac hypertrophy. Under hypertrophic stimulation, cardiomyocytes‐specific overexpression FBXL4 maintains sarcomere integrity and cardiac function by enhancing K48‐linked ubiquitinated degradation of PFN1 at the K70 site.
Xingda Li, Xueqi He, Xinyuan Hao, Yu Zhang, Xin Zhao, Shuang Wang, Zhenru Wang, Haonan Du, Hongda Li, Lian Yi, Zhimin Du, Weijie Du   +11 more
wiley   +1 more source

Unraveling cardiac anomalies in pediatric neurofibromatosis type 1: insights and implications. [PDF]

Eur J Pediatr
Yahia S, Abdelmoneim Z, Ghozzy D, Wahba Y, Abo-Haded HM.   +4 more
europepmc   +1 more source

Assessment of left ventricular function

Cleveland Clinic Journal of Medicine, 1981
openaire   +2 more sources

Effect of the use and timing of bone marrow mononuclear cell delivery on left ventricular function after acute myocardial infarction: the TIME randomized trial.

Journal of the American Medical Association (JAMA), 2012
J. Traverse, T. Henry, C. Pepine, J. Willerson, David X M Zhao, S. Ellis, J. Forder, R. Anderson, A. Hatzopoulos, M. Penn, E. Perin, J. Chambers, K. Baran, Ganesh Raveendran, C. Lambert, A. Lerman, D. Simon, D. Vaughan, D. Lai, A. Gee, Doris A Taylor, C. Cogle, James D. Thomas, Rachel E. Olson, Sherry Bowman, Judy Francescon, Carrie Geither, E. Handberg, Casey Kappenman, Lynette Westbrook, L. Piller, Lara M. Simpson, S. Baraniuk, Catalin Loghin, D. Aguilar, Sara Richman, C. Zierold, D. Spoon, Judy Bettencourt, Shelly L. Sayre, Rachel W. Vojvodic, S. Skarlatos, D. Gordon, R. F. Ebert, Minjung Kwak, L. Moye, R. Simari   +46 more
semanticscholar   +1 more source

Alternative Pathway for Methyl Supply through the Coupling of SHMT1 and PEMT to Maintain Astrocytic Homeostasis in Parkinson's Disease

Advanced Science, EarlyView.
In Parkinson's disease, SHMT1 downregulation disrupts its interaction with PEMT in astrocytes, reducing SAM levels. This leads to H3K4me1 hypomethylation and decreased Slc1a2/Glul expression, ultimately exacerbating neuroexcitotoxicity and dopaminergic neuron loss.
Yue‐Han Chen, Rong‐Xin Zhu, Nuo‐Xi Zhang, Ting‐Ting Sun, Xi‐Wei Zhang, Yu‐Jie Zhao, Ben‐Yu He, Hang Yao, Ren‐Hong Du, Lei Cao, Wen‐Bin Zhang, Wei‐Guo Liu, Yun Cai, Cong Wang, Gang Hu, Yao Wei, Yang Liu, Ming Lu   +17 more
wiley   +1 more source