Results 111 to 120 of about 557,721 (292)

Association between left ventricular remodeling and lipid profiles in obese children: an observational study

Frontiers in Pediatrics
ObjectiveChildhood obesity has become a prominent issue in the society, which can lead to left ventricular remodeling and severe cardiovascular complications in adulthood.
Ying Tang, Guang-bin Yang, Jun Chen, Ye Chen, Li-chun Hua   +4 more
doaj   +1 more source

SerpinA3 is an Endogenous TGF‐β Receptor Antagonist that Attenuates Cardiac Fibroblast Activation and Fibrotic Remodeling

Advanced Science, EarlyView.
SerpinA3 acts as an endogenous TGF‐β receptor antagonist that binds to the extracellular domain of TGFR‐1, thereby preventing TGFR‐1–TGFR‐2 complex formation. This receptor‐level blockade suppresses TGF‐β/Smad2/3 signaling, attenuates cardiac fibroblast activation, and extracellular matrix deposition, and ultimately alleviates pressure overload–induced
Hui Wang, Jieyu Cui, Chunlu Huang, Wanyi Guo, Tong Liu, Yi Zhu, Shuai Shao, Kangyin Chen, Jinlong He, Qiankun Bao   +9 more
wiley   +1 more source

Corrigendum: Pinocembrin Decreases Ventricular Fibrillation Susceptibility in a Rat Model of Depression

Frontiers in Pharmacology, 2021
Tianxin Ye, Tianxin Ye, Tianxin Ye, Cui Zhang, Cui Zhang, Cui Zhang, Gang Wu, Gang Wu, Gang Wu, Weiguo Wan, Weiguo Wan, Weiguo Wan, Yan Guo, Yan Guo, Yan Guo, Yuhong Fo, Yuhong Fo, Yuhong Fo, Xiuhuan Chen, Xiuhuan Chen, Xiuhuan Chen, Xin Liu, Xin Liu, Xin Liu, Qian Ran, Qian Ran, Qian Ran, Jinjun Liang, Jinjun Liang, Jinjun Liang, Shaobo Shi, Shaobo Shi, Shaobo Shi, Bo Yang, Bo Yang, Bo Yang   +35 more
doaj   +1 more source

Macrophage PARP7 Alleviates Septic Cardiomyopathy by Interacting With TBK1 and Suppressing TBK1‐Driven Inflammatory Response

Advanced Science, EarlyView.
In septic cardiomyopathy, PARP7 directly binds TBK1 and mediates its ADP‐ribosylation, thereby repressing TBK1‐driven proinflammatory signaling in macrophages. ABSTRACT Septic cardiomyopathy is a life‐threatening complication of sepsis, and an uncontrolled inflammatory response represents a key pathogenic mechanism. PARP7 negatively regulates the IFN‐I
Jibo Han, Lintao Wang, Xin Zhong, Shenggang Zhao, Huihui Xie, Xue Han, Liming Lin, Yiting Lyu, Ke Xu, Jiajun Xu, Xiaowen Shi   +10 more
wiley   +1 more source

CAR‐Engineered Cell Therapies Beyond Cancer: Reprogramming Fibrosis and Immune‐Mediated Inflammation

Advanced Science, EarlyView.
CAR‐engineered cell therapies are expanding beyond cancer toward immune resetting, pathological‐cell clearance, matrix remodeling, and microenvironmental reprogramming in autoimmune, inflammatory, and fibrotic diseases. This Review compares CAR‐T, CAR‐macrophage, and CAR‐NK platforms and proposes controllable spatiotemporal reprogramming to align ...
Peng Jun Xu, Zhou Jing Zhang, Jing Jin, Hai Yuan Xu, Ya Xin Gu, Qian Qian Yang, You Lang Zhou   +6 more
wiley   +1 more source

The relationship between different ventricular rate control levels and cardiac remodeling in early persistent atrial fibrillation: a prospective cohort study

Frontiers in Cardiovascular Medicine
BackgroundAtrial fibrillation (AF) is a prevalent cardiac arrhythmia, with ventricular rate control being a critical therapeutic target. However, the optimal range for ventricular rate control remains unclear.
Yongrong Liu, Jun Liu, Dan Wang
doaj   +1 more source

Nrsn1–Smarcc1 Coupling Regulates Neural Stem Cell Differentiation and Chronic‐phase Recovery After Ischemic Stroke

Advanced Science, EarlyView.
In the post‐stroke brain, Foxa2 induces the transcriptional upregulation of Nrsn1 in NSCs. Nrsn1 functionally couples with Smarcc1, modulating its nuclear availability and protein abundance, thereby influencing Smarcc1‐associated regulatory programs linked to neuronal lineage commitment. Through this coupling, Nrsn1 promotes the differentiation of NSCs
Ruolin Zhang, Chang Liu, Yuneng Zhou, Kaichen Zhao, Muyang Li, Bingcheng Cai, Ying Wang, Zhiyuan Yuan, Zhaoxin Liu, Zilong Yuan, Yao Xiao, Peiyang Zhou, Ke Shui, Wendai Bao, Min Zhang, Jun Qin, Jun Chen, Xin Yang, Zhiqiang Dong   +18 more
wiley   +1 more source

Differentiation of left ventricular deformation using 2D speckle tracking based on left ventricular geometric pattern in a hypertensive population: a single-center study

Arterial Hypertension
BACKGROUND: Left ventricular (LV) adaptation to arterial hypertension can result in different geometric responses with different hemodynamic patterns.
Mefri Yanni, Nani Nani, Wulan Prisilla
doaj   +1 more source

Cardiac Device Algorithms for Optimal Outcomes in Patients with Sick Sinus Syndrome [PDF]

, 2013
Sick sinus syndrome (SSS) is a relatively common chronic condition affecting the electrical conduction system of the heart. In the absence of any reversible cause of SSS, the most effective treatment is implantation of a permanent pacemaker to maintain ...
CURRY, JANE,KATHERINE
core  

Left Ventricular Remodeling in Patients with Stable Angina Complicated by Heart Failure with Reduced and Preserved Ejection Fraction

, 2016
Introduction. Chronic heart failure is one of the most common and serious diseases of cardiovascular system, resulting in permanent disability and significantly reducing the length and quality of life.
Muzyka N., Denesyuk V., Denesyuk O.
core   +1 more source