Results 41 to 50 of about 123,523 (307)

Ventricular remodelling and revascularization in severe left ventricular dysfunction [PDF]

European Journal of Cardio-Thoracic Surgery, 1998
To evaluate the role of surgical revascularization in the presence of severe, global impairment of left ventricular function without discrete aneurysm formation or mitral regurgitation. The high mortality and morbidity associated with this group, together with the limited benefits tend to prompt referral for cardiac transplantation.Fifty-three patients
V L, Pathi, T M, Pillay, K, Lall, R, Williams, W, Martin, S K, Naik   +5 more
openaire   +2 more sources

Artificial Intelligence in Systemic Sclerosis: Clinical Applications, Challenges, and Future Directions

Arthritis Care &Research, EarlyView.
Systemic sclerosis (SSc) is a rare autoimmune disease defined by immune dysregulation, vasculopathy, and progressive fibrosis of the skin and internal organs. Despite advances in care, major complications such as interstitial lung disease (ILD) and myocardial involvement remain the leading causes of morbidity and mortality.
Cristiana Sieiro Santos, José Miguel Sequí‐Sabater, Diego Benavent   +2 more
wiley   +1 more source

The effect of exercise training on transverse tubules in normal, remodeled, and reverse remodeled hearts [PDF]

, 2011
The response of transverse (T)-tubules to exercise training in health and disease remains unclear. Therefore, we studied the effect of exercise training on the density and spacing of left ventricle cardiomyocyte T-tubules in normal and remodeled hearts ...
Kemi, Ole J., Wisloff, Ulrik, Koch, Lauren G., Morten A. Hoydal, MacQuaide, Niall, Haram, Per M., Godfrey L. Smith, Steven L. Britton, Hoydal, Morten A., Smith, Godfrey L., Ellingsen, Oyvind, Per M. Haram, Lauren G. Koch, Oyvind Ellingsen, Britton, Steven L., Niall MacQuaide, Ole J. Kemi, Ulrik Wisloff   +17 more
core   +1 more source

Microenvironmental Reprogramming by 3D Anisotropic Cardiac Extracellular Matrix Induces Nuclear Remodeling and Epigenetic Maturation of Chemically Induced Cardiomyocytes

Advanced Functional Materials, EarlyView.
A 3D anisotropic hydrogel derived from heart extracellular matrix guides cytoskeletal alignment and nuclear remodeling in reprogrammed cardiomyocyte‐like cells. This study reveals how matrix alignment modulates nuclear envelope dynamics and chromatin state, triggering transcriptional and functional maturation.
Seung Ju Seo, Mi Jeong Lee, Hyun Wook Kang, Seonhee Byeon, Soo‐Kyoung Choi, Nakwon Choi, Seung‐Woo Cho, Yoonhee Jin   +7 more
wiley   +1 more source

Hypothermia and postconditioning after cardiopulmonary resuscitation reduce cardiac dysfunction by modulating inflammation, apoptosis and remodeling

, 2009
Background: Mild therapeutic hypothermia following cardiac arrest is neuroprotective, but its effect on myocardial dysfunction that is a critical issue following resuscitation is not clear.
Meybohm, Patrick, Zitta, Karina, Matthias Gruenewald, Nguyen Tran, Grünewald, Matthias Lars, Martin Albrecht, Koch, Alexander, Karina Zitta, Lucius, Ralph, Scholz, Jens, Kai D Zacharowski, Patrick Meybohm, Bein, Berthold Helmut, Berthold Bein, Albrecht, Martin, Ralph Lucius, Jens Scholz, Alexander Koch, Zacharowski, Kai, Tran, Thi Hoai Nguyen   +19 more
core   +1 more source

Duration of heart failure and the risk of atrial fibrillation: different mechanisms at different times? [PDF]

, 2009
Chronic heart failure increases the risk of atrial fibrillation (AF), with the prevalence of AF paralleling the severity of heart failure.1 Factors that underlie this increased susceptibility to AF may include electrical, structural, and neurohumoral ...
Rankin, A.C., Workman, A.J.
core   +1 more source

Microfabricated Anisotropic Myobundles for the Scalable Production of Cardiac Tissue Grafts

Advanced Functional Materials, EarlyView.
Controlling the anisotropy of cardiac tissue remains an outstanding challenge in the field of cardiac tissue engineering. Here, we introduce an approach to generate anisotropic cardiac myobundles using cell‐adhesive, synthetic, electrospun fibers and stem cell‐derived cardiac fibroblasts.
Maggie E. Jewett, Javiera Jilberto, Margaret E. Stanley, David O. Ntim, Siddhi M. Bhirud, Avianna T. Schroeder, Gonzola X. Anyosa Galvez, Jingyi Xia, Samuel J. DePalma, Emmanouil Agrafiotis, Susan S. Xi, Amanda S. Bluem, Courtney M. Lestock, Adam S. Helms, David A. Nordsletten, Brendon M. Baker   +15 more
wiley   +1 more source

Infusible Extracellular Matrix Biomaterial Enhances Cell‐Specific Pro‐Repair Responses Following Acute Myocardial Infarction

Advanced Healthcare Materials, EarlyView.
We measure the cell‐specific responses of administering infusible ECM (iECM) in acute myocardial infarction (MI) across multiple timepoints. Using single‐nucleus RNA sequencing and spatial transcriptomics, we measure macrophage activation, fibroblast remodeling, increased vascular development, lymphangiogenesis, cardioprotection, and neurogenesis ...
Joshua M. Mesfin, Alexander Chen, Quincy P. Lyons, Michael B. Nguyen, Maria L. Karkanitsa, Justin Yu, Van K. Ninh, Emily Gardner, Elyse G. Wong, Sriya N. Paleti, Julian Cheng, Benjamin D. Bridgelal, Kate E. Reimold, Selena Cao, Connor Uhre, Colin G. Luo, Zhenxing Fu, Kevin R. King, Karen L. Christman   +18 more
wiley   +1 more source

SENP1‐Mediated HSP90ab1 DeSUMOylation in Cardiomyocytes Prevents Myocardial Fibrosis by Paracrine Signaling

Advanced Science
Myocardial infarction (MI) triggers a poor ventricular remodeling response, but the underlying mechanisms remain unclear. Here, the authors show that sentrin‐specific protease 1 (SENP1) is downregulated in post‐MI mice and in patients with severe heart ...
Zhihao Liu, Xiyun Bian, Lan Li, Li Liu, Chao Feng, Ying Wang, Jingyu Ni, Sheng Li, Dading Lu, Yanxia Li, Chuanrui Ma, Tian Yu, Xiaolin Xiao, Na Xue, Yuxiang Wang, Chunyan Zhang, Xiaofang Ma, Xiumei Gao, Xiaohui Fan, Xiaozhi Liu, Guanwei Fan   +20 more
doaj   +1 more source

Altitude‐Related Differences in Biventricular Remodeling and the Clinical Profile of Pulmonary Hypertension: An Exploratory Cardiovascular Magnetic Resonance Study

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Residence at high altitudes (HAs) may increase cardiovascular risk due to hypobaric hypoxia, but its synergy with pulmonary hypertension cause is unclear.
Wanlin Peng, Wei Bai, Xinyang Lyu, Xu Xu, Keling Liu, Sixian Hu, Wen Zeng, Ting Luo, Yi Luo, Yunlong Hu, Chuan Tian, Xiaoyue Zhou, Zhenlin Li, Chunchao Xia   +13 more
doaj   +1 more source