Results 51 to 60 of about 557,721 (292)

Pro/Anti-Inflammatory Cytokine Imbalance in Postischemic Left Ventricular Remodeling

Mediators of Inflammation, 2010
Objectives. Cytokines play an important role in left ventricular remodeling consequent to myocardial ischemia. The aim of this study was to correlate cytokine production and lymphocyte apoptosis to post-ischemic left ventricular remodeling in patients ...
Pasqui Anna Laura, Di Renzo Michela, Maffei Silvia, Pastorelli Marcello, Pompella Gerarda, Auteri Alberto, Puccetti Luca   +6 more
doaj   +1 more source

Cellular Responses to Mechanical Cues Across Scales: From Fundamental Insights to Translational Potential

Advanced Healthcare Materials, EarlyView.
This review examines how cellular behavior is regulated by mechanical cues transmitted through soft biomaterials, from single‐cell mechanosensing to tissue‐level adaptation. It highlights why physiological relevance, rather than model complexity alone, is critical for translational mechanobiology and introduces a scoring framework linking material ...
Mathias Polz, Manuel P. Kainz, Niklas Haider, Theresa Rienmüller, Kerstin Lenk, Rupert Kargl, Michele Terzano, Gerhard Sommer, Gerhard A. Holzapfel, Julia Fuchs   +9 more
wiley   +1 more source

The clinical, electrocardiographic and echocardiographic features and long-term outcome of patients with Tachycardia-induced cardiomyopathy [PDF]

, 2010
Includes abstract.Includes bibliographical references.Tachycardia-induced cardiomyopathy (TIC) is a reversible cause of LV systolic dysfunction that can complicate any supraventricular or ventricular tachyarrhythmia.
Chin, Ashley
core   +1 more source

Patient‐Derived 3D Heart‐On‐a‐Chip Model of Dilated Cardiomyopathy With Embedded Bead‐Based Mapping of Tissue Contractility

Advanced Healthcare Materials, EarlyView.
A heart‐on‐a‐chip model of dilated cardiomyopathy is developed from patient‐derived induced pluripotent stem cells. The model recapitulates key disease phenotypes and enables functional assessment through integrated bead‐based tracking and pillar deflection measurements.
Ali Mousavi, Ludovic Mouttet, Shihao Cui, Yasaman Hekmatnia, Mehran Mottahedi, Ida Derish, Naimeh Rafatian, Mark Aurousseau, Gregor Andelfinger, Renzo Cecere, Houman Savoji   +10 more
wiley   +1 more source

Determination of L-Type Calcium Current in the Primary Hypertrophied Left Ventricular Cardiomyocytes of Hypertrophy Heart Rats/HHR [PDF]

, 2009
Background: The molecular mechanisms responsible for electromechanical derangements found in primary left ventricular (LV) hypertrophy have not been clearly elucidated.
Danes, V. R. (Vennetia), Danes, Vennetia R.   +1 more
core   +1 more source

SENP1‐Mediated HSP90ab1 DeSUMOylation in Cardiomyocytes Prevents Myocardial Fibrosis by Paracrine Signaling

Advanced Science
Myocardial infarction (MI) triggers a poor ventricular remodeling response, but the underlying mechanisms remain unclear. Here, the authors show that sentrin‐specific protease 1 (SENP1) is downregulated in post‐MI mice and in patients with severe heart ...
Zhihao Liu, Xiyun Bian, Lan Li, Li Liu, Chao Feng, Ying Wang, Jingyu Ni, Sheng Li, Dading Lu, Yanxia Li, Chuanrui Ma, Tian Yu, Xiaolin Xiao, Na Xue, Yuxiang Wang, Chunyan Zhang, Xiaofang Ma, Xiumei Gao, Xiaohui Fan, Xiaozhi Liu, Guanwei Fan   +20 more
doaj   +1 more source

Right Atrial-to-Right Ventricular Area

JACC: Advances
Background: Severe secondary tricuspid regurgitation (STR) in heart failure patients is associated with excess mortality. Quantification associated risk assessment, remains challenging, specifically with contextual anatomic variability.
Charlotte Jantsch, MD, Sophia Koschatko, MD, TingTing Wu, MD, Christoph Torrefranca, MD, Kseniya Halavina, MD, Varius Dannenberg, MD, Caglayan Demirel, MD, Christian Nitsche, MD, PhD, Laurenz Hauptmann, MD, Maximilian Autherith, MD, Georg Goliasch, MD, PhD, Christian Hengstenberg, MD, Noemi Pavo, MD, PhD, Philipp E. Bartko, MD, PhD, Gregor Heitzinger, MD, PhD   +14 more
doaj   +1 more source

From Fiber Bundles to Architected Membranes: Triply Periodic Minimal Surface Architectures for Biohybrid Artificial Lungs

Advanced Materials, EarlyView.
Additively manufactured triply periodic minimal surface (TPMS) membranes offer an architecture‐driven alternative to hollow fiber bundles in artificial lungs. Multiphysics simulations and endothelialized prototypes show that the 3D‐printable membrane architecture improves gas exchange, blood flow distribution, and hemocompatibility, enabling ...
Michael Pflaum, Kai P. Barbian, Florian Neuhaus, Gerrit Sitarz, Carolin Nölke, Sebastian V. Jansen, John Linkhorst, Lukas T. Hirschwald, Sebastian Brosch, Christian Certa, Ulrich Steinseifer, Matthias Wessling, Jutta Arens, Arjang Ruhparwar, Bettina Wiegmann   +14 more
wiley   +1 more source

Advanced Materials for Biologics Delivery to Brain Tumors

Advanced Materials, EarlyView.
Material innovation is central to unlocking the therapeutic potential of biologics against many central nervous system diseases, including brain cancer. By engineering carriers with controlled transport, targeting, and release properties, advanced materials can overcome the blood–brain barrier and tumor microenvironment, improving the delivery of ...
Yuran Feng, Yuxue Cao, Maria Kavallaris, Taskeen Janjua, Amirali Popat   +4 more
wiley   +1 more source

Altitude‐Related Differences in Biventricular Remodeling and the Clinical Profile of Pulmonary Hypertension: An Exploratory Cardiovascular Magnetic Resonance Study

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Residence at high altitudes (HAs) may increase cardiovascular risk due to hypobaric hypoxia, but its synergy with pulmonary hypertension cause is unclear.
Wanlin Peng, Wei Bai, Xinyang Lyu, Xu Xu, Keling Liu, Sixian Hu, Wen Zeng, Ting Luo, Yi Luo, Yunlong Hu, Chuan Tian, Xiaoyue Zhou, Zhenlin Li, Chunchao Xia   +13 more
doaj   +1 more source