Results 61 to 70 of about 188,365 (337)

SENP1‐Mediated HSP90ab1 DeSUMOylation in Cardiomyocytes Prevents Myocardial Fibrosis by Paracrine Signaling

Advanced Science
Myocardial infarction (MI) triggers a poor ventricular remodeling response, but the underlying mechanisms remain unclear. Here, the authors show that sentrin‐specific protease 1 (SENP1) is downregulated in post‐MI mice and in patients with severe heart ...
Zhihao Liu, Xiyun Bian, Lan Li, Li Liu, Chao Feng, Ying Wang, Jingyu Ni, Sheng Li, Dading Lu, Yanxia Li, Chuanrui Ma, Tian Yu, Xiaolin Xiao, Na Xue, Yuxiang Wang, Chunyan Zhang, Xiaofang Ma, Xiumei Gao, Xiaohui Fan, Xiaozhi Liu, Guanwei Fan   +20 more
doaj   +1 more source

Right Atrial-to-Right Ventricular Area

JACC: Advances
Background: Severe secondary tricuspid regurgitation (STR) in heart failure patients is associated with excess mortality. Quantification associated risk assessment, remains challenging, specifically with contextual anatomic variability.
Charlotte Jantsch, MD, Sophia Koschatko, MD, TingTing Wu, MD, Christoph Torrefranca, MD, Kseniya Halavina, MD, Varius Dannenberg, MD, Caglayan Demirel, MD, Christian Nitsche, MD, PhD, Laurenz Hauptmann, MD, Maximilian Autherith, MD, Georg Goliasch, MD, PhD, Christian Hengstenberg, MD, Noemi Pavo, MD, PhD, Philipp E. Bartko, MD, PhD, Gregor Heitzinger, MD, PhD   +14 more
doaj   +1 more source

Implantation of a poly-L-lactide GCSF-functionalized scaffold in a model of chronic myocardial infarction [PDF]

, 2017
A previously developed poly-l-lactide scaffold releasing granulocyte colony-stimulating factor (PLLA/GCSF) was tested in a rabbit chronic model of myocardial infarction (MI) as a ventricular patch.
Chello, Massimo, Crescenzi, Anna, De Marco, Federico, Gambardella, Ivancarmine, Nappi, Francesco, Nenna, Antonio, Rainer, Alberto, Sedati, Pietro, Spadaccio, Cristiano, Taffon, Chiara, Trombetta, Marcella   +10 more
core   +1 more source

Infusible Extracellular Matrix Biomaterial Enhances Cell‐Specific Pro‐Repair Responses Following Acute Myocardial Infarction

Advanced Healthcare Materials, EarlyView.
We measure the cell‐specific responses of administering infusible ECM (iECM) in acute myocardial infarction (MI) across multiple timepoints. Using single‐nucleus RNA sequencing and spatial transcriptomics, we measure macrophage activation, fibroblast remodeling, increased vascular development, lymphangiogenesis, cardioprotection, and neurogenesis ...
Joshua M. Mesfin, Alexander Chen, Quincy P. Lyons, Michael B. Nguyen, Maria L. Karkanitsa, Justin Yu, Van K. Ninh, Emily Gardner, Elyse G. Wong, Sriya N. Paleti, Julian Cheng, Benjamin D. Bridgelal, Kate E. Reimold, Selena Cao, Connor Uhre, Colin G. Luo, Zhenxing Fu, Kevin R. King, Karen L. Christman   +18 more
wiley   +1 more source

Altitude‐Related Differences in Biventricular Remodeling and the Clinical Profile of Pulmonary Hypertension: An Exploratory Cardiovascular Magnetic Resonance Study

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Residence at high altitudes (HAs) may increase cardiovascular risk due to hypobaric hypoxia, but its synergy with pulmonary hypertension cause is unclear.
Wanlin Peng, Wei Bai, Xinyang Lyu, Xu Xu, Keling Liu, Sixian Hu, Wen Zeng, Ting Luo, Yi Luo, Yunlong Hu, Chuan Tian, Xiaoyue Zhou, Zhenlin Li, Chunchao Xia   +13 more
doaj   +1 more source

Predictors of Left Ventricular Remodeling Post Acute Myocardial Infarction. Protocol for a Clinical Study

Journal of Interdisciplinary Medicine, 2019
Heart failure is a clinical syndrome that appears as a consequence of a structural disease, and the most common cause of left ventricular systolic dysfunction results from myocardial ischemia.
Cîrneală Ioana, Opincariu Diana, Kovács István, Chițu Monica, Benedek Imre   +4 more
doaj   +1 more source

Relationship of left ventricular, elastic and muscular arteries remodeling in patients with uncontrolled arterial hypertension

Patologìâ, 2013
Introduction. Uncontrolled hypertension is observed in 65-92% of hypertensive patients. It plays an important role in the development of adverse cardiovascular events and survival, which depend on subclinical target organ damage. There are reports on the
S. Ya. Dotsenko, V. G. Deynega, N. Ya. Dotsenko   +2 more
doaj   +1 more source

Electrophysiological and structural remodeling in heart failure modulate arrhythmogenesis. 1D simulation study. [PDF]

PLoS ONE, 2014
Heart failure is a final common pathway or descriptor for various cardiac pathologies. It is associated with sudden cardiac death, which is frequently caused by ventricular arrhythmias.
Juan F Gomez, Karen Cardona, Lucia Romero, Jose M Ferrero, Beatriz Trenor   +4 more
doaj   +1 more source

A 3D Astrocyte Microenvironment Model Enables Rapid Ca2+‐Resolved Analysis and Therapeutic Modulation of Oxidative Neuroinflammation

Advanced Healthcare Materials, EarlyView.
This work presents ARC‐3D, a soft 3D model that recreates how brain support cells, called astrocytes, react to oxidative stress. The system visualizes rapid calcium changes and inflammatory signals, and shows how the drug KDS12025 can protect cells from damage. ARC‐3D offers a simple, reliable way to study early drivers of brain inflammation.
Ju‐Kang Kim, Ye‐Ji Kim, Seyoung Ryu, Daeui Park, Kyoung‐Sik Moon, Yu Bin Lee, Dong Ho Woo   +6 more
wiley   +1 more source

Value of cardiac magnetic resonance tissue tracking imaging for assessment of early cardiac function in rats with left ventricular remodeling

陆军军医大学学报, 2023
Objective To investigate the value of 7.0T cardiac magnetic resonance tissue tracking imaging (CMR-TT) in evaluation of cardiac function in rats with early left ventricular remodeling induced by isoproterenol (ISO). Methods Eighteen male healthy specific
LI Haichen, LI Mei, HUANG Ruijue, WEN Xiaojuan, ZHANG Mingxing   +4 more
doaj   +1 more source