Decreased soluble guanylate cyclase contributes to cardiac dysfunction induced by chronic doxorubicin treatment in mice [PDF]
, 2017 Aims: The use of doxorubicin, a potent chemotherapeutic agent, is limited by cardiotoxicity. We tested the hypothesis that decreased soluble guanylate cyclase (sGC) enzyme activity contributes to the development of doxorubicin-induced cardiotoxicity ...
Allen, Kaitlin +15 more
core +1 more source
Changes in left atrial deformation in hypertrophic cardiomyopathy: Evaluation by vector velocity imaging. [PDF]
, 2012 OBJECTIVES: Hypertrophic cardiomyopathy (HCM) represents a generalized myopathic process affecting both ventricular and atrial myocardium. We assessed the global and regional left atrial (LA) function and its relation to left ventricular (LV) mechanics ...
Badran, HM +6 more
core +2 more sources
Serotonin signaling through the 5-HT1B receptor and NADPH oxidase 1 in pulmonary arterial hypertension [PDF]
, 2017 Objective: Serotonin can induce human pulmonary artery smooth muscle cell (hPASMC) proliferation through reactive oxygen species (ROS), influencing the development of pulmonary arterial hypertension (PAH). We hypothesise that in PASMCs, serotonin induces
Harvey, Adam P. +5 more
core +2 more sources
Ventricular‐Arterial Function and Coupling in the Adult Fontan Circulation
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2016 Background In adult Fontan patients, ventricular or arterial dysfunction may impact homeostasis of the Fontan circulation and predispose to heart failure. We sought to characterize ventricular‐arterial (VA) properties in adult Fontan patients.
Hirofumi Saiki +4 more
doaj +1 more source
Short term doxycycline treatment induces sustained improvement in myocardial infarction border zone contractility. [PDF]
, 2018 Decreased contractility in the non-ischemic border zone surrounding a MI is in part due to degradation of cardiomyocyte sarcomeric components by intracellular matrix metalloproteinase-2 (MMP-2).
Aguayo, Esteban +11 more
core +2 more sources
Left ventricular assist device-induced reverse ventricular remodeling
Progress in Cardiovascular Diseases, 2000 Left ventricular assist devices provide chronic pressure and volume unloading of the dilated left ventricle in patients with end-stage heart failure. This is associated with reverse structural remodeling (normalization of the passive pressure-volume relationship), reverse molecular remodeling (increased expression of several genes involved in calcium ...
D, Burkhoff +4 more
openaire +2 more sources
Role of cardiac resynchronization therapy in the development of new-onset atrial fibrillation: A single-center prospective study. [PDF]
, 2012 Albeit several studies examined the association between cardiac resynchronization therapy (CRT) and atrial fibrillation (AF) in heart failure (HF), results are still unclear and quite conflicting.
Cristofaro d' +3 more
core +3 more sources
An unusual case of cardiac dysfunction after left ventricular reconstruction
Journal of Cardiothoracic Surgery, 2006 This report describes an unusual cause of low cardiac output after coronary artery bypass grafting and left ventricular remodeling. It details left ventricular remodeling techniques and discusses the most recent advances and outcomes.
Fedoruk Lynn M, Kron Irving L
doaj +1 more source
Enhanced cardiac expression of two isoforms of matrix metalloproteinase-2 in experimental diabetes mellitus. [PDF]
, 2019 BackgroundDiabetic cardiomyopathy (DM CMP) is defined as cardiomyocyte damage and ventricular dysfunction directly associated with diabetes independent of concomitant coronary artery disease or hypertension.
Ahn, Jinhee +15 more
core +2 more sources
Magnetic resonance imaging of myocardial strain after acute ST-segment-elevation myocardial infarction: a systematic review [PDF]
, 2017 The purpose of this systematic review is to provide a clinically relevant, disease-based perspective on myocardial strain imaging in patients with acute myocardial infarction or stable ischemic heart disease.
Auger, Daniel A. +4 more
core +1 more source