Results 111 to 120 of about 29,656 (290)

Ventricular activation and repolarization in response to physiological and conventional pacing using ultra-high-frequency electrocardiography.

PLoS ONE
BackgroundPhysiological pacing targeting the cardiac conduction system is increasingly being adopted as an alternative to conventional right ventricular (RV) pacing for the treatment of bradyarrhythmias, although its effects on ventricular repolarization
Saúl Palacios, Radovan Smisek, Karol Curila, Uyen Nguyen, Frits W Prinzen, Josef Halamek, Filip Plesinger, Pavel Jurak, Javier Ramos, Juan Pablo Martínez, Esther Pueyo   +10 more
doaj   +1 more source

The influence of delayed ventricular activation on cardiac repolarization: Insights from electrocardiographic imaging

The Journal of Physiology, EarlyView.
Abstract figure legend This study examines the relationships between activation and repolarization times in epicardial reconstructed unipolar electrograms derived from ECG‐imaging in patients with normal and delayed ventricular activation. In patients with a narrow QRS‐complex, ECG‐imaging reveals significant variability in the activation ...
Karin C. Smits, Ted E.M. Lempers, Marc Strik, Job Stoks, Roel Meiburg, Matthijs J.M. Cluitmans, Paul G.A. Volders, Kevin Vernooy, Frits W. Prinzen, Uyên Châu Nguyên   +9 more
wiley   +1 more source

Repolarization adaptation to rapid change in heart rate in human models – a review

The Journal of Physiology, EarlyView.
Abstract figure legend This review focuses on non‐invasive assessment of repolarization duration and dispersion (heterogeneity) adaptation to change in heart rate (HR). HR was increased incrementally by left atrial pacing during an electrophysiology (EP) study and by a bolus injection of atropine and in a step up/down fashion by repeated right atrial ...
Lennart Bergfeldt, Karl‐Jonas Axelsson, Pia Dahlberg, Farzad Vahedi, Gunilla Lundahl, Lennart Gransberg   +5 more
wiley   +1 more source

Ventricular repolarization in overweight and normal weight healthy young men

, 2008
Objective: The effects of body mass index (BMI) on ventricular repolarization in young men have not been studied in detail. The QT and JT intervals are measured to estimate the duration of the ventricular repolarization. As new repolarization parameters,
Turan, Nesrin, Oztuerk, Leven, Altun, Armagan, Vardar, Selma Arzu   +3 more
core  

Electromechanical modelling and simulation of human‐induced pluripotent stem cell‐derived cardiomyocytes predict drug‐induced contractility effects

The Journal of Physiology, EarlyView.
Abstract figure legend A study described in this paper describes a new tool for hiPSC‐CM electromechanical behaviour simulations using mathematical modelling. The model enables in silico assays making drug testing quick, comprehensive and accurate. New hiPSC‐CM models can be used as a platform to integrate in vitro and in silico findings.
Milda Folkmanaite, Xin Zhou, Andreas Koschinski, Wan‐Hua Hong, Marilù Casini, Manuel Koch, Ursula Ravens, Remi Peyronnet, Manuela Zaccolo, Blanca Rodriguez   +9 more
wiley   +1 more source

Sustained Atrial Fibrillation Induced by Commotio Cordis-Like Event in a Pediatric Patien

Journal of Cardiovascular Emergencies
Commotio cordis (CC), or concussion of the heart, is typically characterized by a sudden impact to the chest wall precipitating ventricular fibrillation arrest.
Van Ee Shantele Kemp, Elortegui Alexander, O’Toole Francis, Anderson Jonathan   +3 more
doaj   +1 more source

Computational modelling of the pro‐ and antiarrhythmic effects of atrial high rate‐dependent trafficking of small‐conductance calcium‐activated potassium channels

The Journal of Physiology, EarlyView.
Abstract figure legend Small‐conductance calcium‐activated potassium (SK) channels are important for atrial repolarization and can be targeted for atrial‐specific antiarrhythmic treatments. We developed a computational model with a calcium sensor to study the effects of increased pacing rate (5 Hz), which enhances SK‐channel gating and forward ...
Stefan Meier, Dobromir Dobrev, Paul G. A. Volders, Jordi Heijman   +3 more
wiley   +1 more source

Targeted M‐Channel Activation in the Left Stellate Ganglion Protects Against Ischemia‐Induced Ventricular Arrhythmias in Canines

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Acute myocardial ischemia (AMI)‐triggered ventricular arrhythmias are closely linked to maladaptive sympathetic hyperactivity mediated via the left stellate ganglion (LSG).
Jin‐qiang Peng, Ming‐min Zhou, Liao Xu, Xi Wang, Yan‐hong Tang, Yu Liu   +5 more
doaj   +1 more source

Early repolarization in mice causes overestimation of ventricular activation time by the QRS duration

, 2013
Item does not contain fulltextAIMS: Transgenic mice are frequently used to investigate the role of genes involved in cardiac conduction. The QRS duration calculated from the electrocardiogram (ECG) is a commonly used measure for ventricular conduction ...
Coronel, R., Boukens, Bas J., Boukens, B.J., Dam, P.M. van, Linnenbank, Andre, Christoffels, Vincent M., Fiolet, J.W., van Dam, Peter, Fiolet, Jan W., Verkerk, A.O., Linnenbank, A., Hoogendijk, Mark G., Opthof, Tobias, Hoogendijk, M.G., Remme, C.A., Remme, Carol-Ann, Opthof, T., Verkerk, Arie O., Coronel, Ruben, Christoffels, V.M.   +19 more
core   +1 more source

In silico predictions of action potential propagation in doxorubicin cardiotoxicity: A parametric study using preclinical 3D magnetic resonance imaging‐based fibrotic left ventricle models

The Journal of Physiology, EarlyView.
Abstract figure legend Schematic overview of the study's methodology and key findings. In a preclinical swine model, doxorubicin administration induced cardiotoxicity, characterized by diffuse fibrotic remodelling and altered electrical function, as assessed by magnetic resonance (MR) imaging and electrophysiological mapping.
Javier Villar‐Valero, Jairo Rodríguez Padilla, Nicolas Cedilnik, Buntheng Ly, Juan F. Gomez, Maxime Sermesant, Mihaela Pop, Beatriz Trenor   +7 more
wiley   +1 more source