Results 121 to 130 of about 29,656 (290)

Amiodarone and Homogeneity of Ventricular Repolarization and Refractoriness

Journal of Cardiovascular Pharmacology and Therapeutics, 1996
Aniiodarone was synthesized in 1962 by a brilliant team of pharmacologists and organic chemists who were looking for a potent coronary vasodilator as a derivative of the khellin molecule (1). They focused on the benzfunn part of the molecule with the addition of a benzene ring and terminal nitrogen in the side chain.
openaire   +2 more sources

Malignant arrhythmia in apical ballooning syndrome: risk factors and outcomes.

, 2008
Objectives: We sought to determine the frequency and outcomes with symptomatic arrhythmia in patients with apical ballooning syndrome (ABS). Methods: A retrospective review of the Mayo Clinic Angiography database was conducted to identify patients who
Prasad, A, Ahmad, E, Asirvatham, SJ, Rihal, CS, Dib, C, Friedman, PA, Hammill, SC   +6 more
core  

Combined inhibition of atrial‐specific potassium currents as a possible anti‐arrhythmic drug therapy: A match made in silico

The Journal of Physiology, EarlyView.
Vladimír Sobota
wiley   +1 more source

Deciphering pro‐arrhythmogenic mechanisms of EPAC in human atrial cardiomyocytes

The Journal of Physiology, EarlyView.
Abstract figure legend This study aimed to investigate the effect of exchange proteins directly activated by cAMP (EPAC) on the regulation of human atrial cardiomyocyte electrophysiology and their potential involvement in the onset of atrial fibrillation (AF).
Arthur Boileve, Margaux Aize, Maximin Détrait, Laura Brard, Adrien Leboyer, Pierre‐Antoine Dupont, Alexandre Lebrun, Vladimir Saplacan, Christophe Simard, Fabien Brette, Frank Lezoualc'h, Laurent Sallé   +11 more
wiley   +1 more source

Mechanistic insights into sex differences in atrial electrophysiology and arrhythmia vulnerability through sex‐specific computational models

The Journal of Physiology, EarlyView.
Abstract figure legend Sex‐specific models of the human atrial myocyte in normal sinus rhythm (nSR) and chronic atrial fibrillation (cAF) revealed increased alternans susceptibility in cAF males and DADs in females, driven primarily by ICaL and ryanodine receptor remodelling.
Nathaniel T. Herrera, Haibo Ni, Charlotte E. R. Smith, Yixuan Wu, Dobromir Dobrev, Stefano Morotti, Eleonora Grandi   +6 more
wiley   +1 more source

Electrocardiographic parameters of ventricular repolarization : modifiers and the prognostic value

, 2011
Electric activity of the heart consists of repeated cardiomyocyte depolarizations and repolarizations. Abnormalities in repolarization predispose to ventricular arrhythmias.
Porthan, Kimmo
core  

Energetic microdomains and the vascular control of neuronal and muscle excitability: Toward a unified model

The Journal of Physiology, EarlyView.
Abstract figure legend The capillary–mitochondria–ion channel (CMIC) axis scales structural resources to match functional workload. (Left) In settings of restricted energetic capacity (e.g. cortical neurons), sparse capillary networks and modest mitochondrial pools set a lower energetic ceiling, sufficient to support phasic, low‐workload excitability. (
L. Fernando Santana, Scott Earley
wiley   +1 more source

Interaction of different potassium channels in cardiac repolarization in dog ventricular preparations: role of repolarization reserve

, 2002
1 The aim of this study was to investigate the possible role of the interaction of different potassium channels in dog ventricular muscle, by applying the conventional microelectrode and whole cell patch-clamp techniques at 37degreesC.
Papp, Julius Gyula, Varró, András, László Virág, Norbert Iost, András Varró, Biliczki, Péter, Péter Biliczki, Julius Gy Papp, Virág, László, Iost, Norbert   +9 more
core   +1 more source

Cellular mechanisms of radiation‐induced myocyte dysfunction: effects on calcium handling, ion channel regulation and mitochondrial energetics

The Journal of Physiology, EarlyView.
Abstract figure legend Dose‐dependent effects of radiation on cardiac electrophysiology and arrhythmia susceptibility. At low radiation doses (left), increased reactive oxygen species (ROS) initiate an ROS–Ca2+ positive feedback loop involving calcium/calmodulin‐dependent protein kinase II (CaMKII) activation, enhanced L‐type Ca2+ current (ICaL ...
Hannah M. Zukowski, Colleen E. Clancy
wiley   +1 more source

Electrocardiographic repolarization parameters in children with arrhythmias and excessive body weight

Archives of Medical Science
Introduction In clinical diagnosis, electrocardiographic repolarization abnormalities with prolongation of QT and especially TpTe intervals are important for assessing the risk of malignant ventricular arrhythmias. The aim of the study was to compare the
Joanna Jaromin, Grażyna Markiewicz-Łoskot, Lesław Szydłowski, Agnieszka Kulawik, Agnieszka Chlebowczyk, Ewa Moric-Janiszewska   +5 more
doaj   +1 more source