Results 111 to 120 of about 25,531 (238)

Self‐Assembled Myricetin‐Arginine Conjugate Nanozymes for Targeted Suppression of Joint Inflammation and Osteoclastogenesis in Rheumatoid Arthritis

Advanced Science, Volume 13, Issue 14, 9 March 2026.
Carrier‐free myricetin‐arginine conjugate nanozymes (MANZs) have been fabricated through a Mannich reaction and spontaneous self‐assembly. MANZs selectively accumulate in inflamed joints by targeting M1 macrophages via CAT2‐mediated uptake. The nanozymes can effectively modulate macrophage polarization, suppress osteoclast differentiation, and mitigate
Jiachang Hong, Penghao Ji, Jinxi An, Junchao Huang, Ziheng Bu, Xudong Zhang, Wei Liu, Tingyu Wu, Sen Wang, Wei Zhu, Yuhui Li, Jixian Wan, Sudan Xu, Minfeng Huo, Peng Wu   +14 more
wiley   +1 more source

Radar-based observation of a lava tube on Venus. [PDF]

Nat Commun
Carrer L, Diana E, Bruzzone L.
europepmc   +1 more source

Integrated Population Pharmacokinetic, Pharmacodynamic, and Safety Analyses to Inform Dosage Selection in the Clinical Development of the ATR Inhibitor Tuvusertib

Clinical Pharmacology &Therapeutics, Volume 119, Issue 3, Page 618-628, March 2026.
We present model‐informed selection of the recommended dose for expansion (RDE) of investigational oral ATR inhibitor tuvusertib, by integrating clinical pharmacokinetics (PK), pharmacodynamics (PD), and safety data from DDRiver Solid Tumors 301 trial Part A1 (NCT04170153).
Jatinder Kaur Mukker, Paul Matthias Diderichsen, Farina Hellmann, Timothy A. Yap, Ruth Plummer, Anthony W. Tolcher, Johann S. de Bono, Ioannis Gounaris, Zoltan Szucs, Astrid Zimmermann, Irina Kareva, Jayaprakasam Bolleddula, Annick Seithel‐Keuth, Giuseppe Locatelli, Marta Enderlin, Christine Hicking, Anup Zutshi, Wei Gao, Rainer Strotmann, Lisa Benincosa, Karthik Venkatakrishnan   +20 more
wiley   +1 more source

IPTG- and estradiol-inducible gene expression systems in the unicellular red alga Cyanidioschyzon merolae. [PDF]

Plant Physiol
Fujiwara T, Hirooka S, Yamashita S, Miyagishima SY.   +3 more
europepmc   +1 more source

Spatial Organization of Morpho‐Electric Subtypes of Pyramidal Neuron in the Subiculum

Hippocampus, Volume 36, Issue 2, March 2026.
ABSTRACT The subiculum is a main output structure of the hippocampus, transmitting information from the CA1 to the entorhinal cortex in a spatially structured manner. Prior studies revealed a high electrophysiological and molecular heterogeneity of subicular pyramidal neurons (PYNs) with evidence for further spatial subdivisions of the subiculum.
Alix Guinet, Joachim Behr, Imre Vida, Sabine Grosser   +3 more
wiley   +1 more source

Enhancing prestin oligomerization for superior sonogenetics. [PDF]

Theranostics
Wang HC, Phan TN, Chen TH, Lin Y, Hsu N, Fan CH, Chiang PH, Chen CH, Yeh CK, Lin YC.   +9 more
europepmc   +1 more source

Light‐Based Molecular Tools to Precisely Monitor and Operate β‐Adrenoceptors

Medicinal Research Reviews, Volume 46, Issue 2, Page 445-474, March 2026.
ABSTRACT β‐Adrenoceptors are important G protein–coupled receptors involved in cardiovascular, metabolic, and neurological regulation. To study their function with high precision, light‐based molecular tools have been developed offering precise spatiotemporal control.
Ignazzitto Maria Tindara, Gómez‐Santacana Xavier, Llebaria Amadeu, Rovira Xavier   +3 more
wiley   +1 more source

Tutorial on WDK-VENUS: A Streamlined and Modular Workflow for High-Temperature Dynamics and Kinetics of Atom-Diatom Collisions. [PDF]

ACS Phys Chem Au
Yang J, Li J.
europepmc   +1 more source

Preservation of Historically and Scientifically Important Geospatial Data From Venus

Earth and Space Science, Volume 13, Issue 3, March 2026.
Abstract A large volume of scientifically and historically important data from the early exploration of Venus is not widely available to researchers. Our work is focused on ameliorating this problem with the archival of geospatial data including radar, topography, and radiometry.
T. J. Austin, J. G. O'Rourke, D. M. Nelson   +2 more
wiley   +1 more source

ARAP1 fine-tunes F-actin polymerization level in lymphocytes through RhoA inhibition. [PDF]

Front Immunol
Ueda Y, Kondo N, Kamioka Y, Kinashi T.
europepmc   +1 more source