Results 151 to 160 of about 101,449 (340)

Cytoplasmic Vacuolization: A Fascinating Morphological Alteration From Cellular Stress to Cell Death

open access: yesCancer Science, EarlyView.
This review provides a thorough examination of contemporary studies on cytoplasmic vacuolization in mammalian cells, elucidating its etiology, origins, and molecular pathways. Additionally, it highlights the potential of CVACD as an innovative therapeutic strategy for cancer.
Xiaoxu Wen, Hongru Ma
wiley   +1 more source

Scalable Matrigel‐Free Suspension Culture for Generating High‐Quality Human Liver Ductal Organoids

open access: yesCell Proliferation, EarlyView.
A novel matrigel‐free suspension culture enhances the generation of high‐quality human liver ductal organoids, which shows remarkable efficacy in mice transplantation. ABSTRACT Liver transplantation is currently the sole definitive treatment option for end‐stage liver failure.
Senyi Gong   +14 more
wiley   +1 more source

A prospective, randomized, single - blind study comparing intraplaque injection of thiocolchicine and verapamil in Peyronie's Disease: a pilot study

open access: yesInternational Brazilian Journal of Urology
Objectives: To compare the response to tiocolchicine and verapamil injection in the plaque of patients with Peyronie's disease. Materials and Methods: Prospective, single-blind, randomized study, selecting patients who have presented Peyronie's disease ...
I. L. Toscano Jr.   +5 more
doaj   +1 more source

STAT3 and Nrf2 pathways modulate the protective effect of verapamil on lung injury of diabetic rats

open access: yesEndocrine Regulations, 2018
Objective. We aimed to assess the protective role of verapamil, L-type calcium channel blockers, against early lung damage in diabetic rats. Lung injury has recently been recognized as a consequent complication of diabetes mellitus. Hyperglycemia induces
Mohamed Mervat Z.   +3 more
doaj   +1 more source

Amitriptyline use in individuals with KCNQ2/3 gain‐of‐function variants: A retrospective cohort study

open access: yesEpilepsia, EarlyView.
Abstract Objective Heterozygous gain‐of‐function (GOF) variants in KCNQ2 and KCNQ3, encoding the voltage‐gated potassium channel subunits Kv7.2 and Kv7.3, lead to neurodevelopmental disorders for which no established treatments are available. Amitriptyline, an antidepressant, blocks Kv7.2/Kv7.3 and has previously been reported to be effective in a ...
Matthias De Wachter   +18 more
wiley   +1 more source

Evaluation of the Analgesic Effect of 2 Doses of Verapamil With Bupivacaine Compared with Bupivacaine Alone in Supraclavicular Brachial Plexus Block

open access: yesMedical Journal of The Islamic Republic of Iran, 2007
Background:Different adjuvant drugs have been used with local anesthetics in order to decrease the time of onset and elongate the duration and quality of regional blocks. This study was performed to study the effects of one of the adjuvants, verapamil,in
M. Kazemi   +4 more
doaj  

Kinetic behavior of the general modifier mechanism of Botts and Morales with non-equilibrium binding

open access: yes, 2011
In this paper, we perform a complete analysis of the kinetic behavior of the general modifier mechanism of Botts and Morales in both equilibrium steady states and non-equilibrium steady states (NESS).
Jia, Chen   +4 more
core   +1 more source

Epilepsy–heart syndrome: Concept, clinical context, and opportunity for integrated care

open access: yesEpilepsia, EarlyView.
Abstract In this concept paper, we introduce epilepsy‐heart syndrome as a shared burden of illness between epilepsy and cardiac disorders. This pragmatic definition is agnostic of which condition came first (the epilepsy or the cardiac disorder), recognising that these conditions can each serve as a risk factor for the other owing to a bidirectional ...
Gashirai K. Mbizvo   +3 more
wiley   +1 more source

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