Results 121 to 130 of about 54,744 (297)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Attribute-based access control using verifiable credentials

Array
Verifiable credentials provide cryptographically verifiable claims about subjects and can therefore serve as a source of trusted attributes for authorization.
Michael Schneider, David Boschert, Sebastian Abeck   +2 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Verifiable reinforcement learning via policy extraction

, 2019
© 2018 Curran Associates Inc.All rights reserved. While deep reinforcement learning has successfully solved many challenging control tasks, its real-world applicability has been limited by the inability to ensure the safety of learned policies.
Bastani, Osbert, Pu, Yewen, Solar Lezama, Armando   +2 more
core  

Design and Extension of Revocable Verifiable Timed Signature Scheme

Tongxin xuebao
The Verifiable Timed Signature achieves the delayed disclosure of the signature by introducing a time-delay mechanism, and allows the verifier to verify or restore the signature after meeting the predetermined time conditions.
Zhang Yanshuo, Cai Runze, Zou Yuyao, Dong Youheng, Wang Caibing   +4 more
doaj  

Icy-DVRF: A Distributed Verifiable Random Function Based on FROST Signatures

IEEE Access
Unbiased and unpredictable randomness is a cornerstone of Web3 security, underpinning everything from consensus protocols to DeFi logic. Although Distributed Verifiable Random Functions (DVRFs) eliminate central points of failure, current designs often ...
Ahmet Ramazan Agirtas, Arda Bugra Ozer, Zulfukar Saygi, Oguz Yayla   +3 more
doaj   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Verifiable Secret Sharing as Secure Computation

, 1994
Verifiable Secret Sharing is a fundamental primitive for secure cryptographic design. We present a stronger notion of verifiable secret sharing and exhibit a protocol implementing it.
Rosario Gennaro, Micali, Silvio, Silvio Micali, Gennaro, Rosario   +3 more
core  

When is explainable AI useful?

Journal of Human-Technology Relations
In this paper I assess the ethical and epistemic utility of explainable AI algorithms. I first distinguish between different types of outputs that AI can have.
Scott Robbins
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source