Results 161 to 170 of about 3,238 (232)

Designer Dynamic DNA Nanoaggregate in Living Cell for Mitochondrial Energy Restriction

Advanced Science, EarlyView.
This study presents the Tech‐tetrahedron, a designer dynamic DNA nanoaggregate engineered for precise mitochondrial energy restriction. Its trinity‐functionalized design integrates navigable unit, telomerase‐activated latch, and self‐assembly module.
Ruijia Deng, Jing Sheng, Ben Niu, Wenjuan Fu, Yingjie Yang, Zuowei Xie, Shuang Xie, Yunxuan He, Meilin Gong, Jue Wang, Yan Pi, Ming Chen, Kai Chang   +12 more
wiley   +1 more source

12-month outcomes of elexacaftor/tezacaftor/ivacaftor (ELX/TEZ/IVA) in rare CFTR missense variant. [PDF]

Genet Med Open
Vekaria S, Al-Abbasi H, Mulrennan S.
europepmc   +1 more source

The Spatiotemporal Genetic Architecture of Seed Vigor in Upland Cotton

Advanced Science, EarlyView.
Leveraging the semi‐automated SeedRanger platform, we profiled the germination kinetics of 356 cotton accessions at a 30‐min interval. This high‐throughput phenomic approach delineated a temporal genetic network comprising 541 stage‐specific loci. Crucially, functional validation identified FLA2 as a pivotal, auxin‐modulated regulator that orchestrates
Luyao Wang, Jie Dai, Ting Zhao, Shengjun Zhao, Hongyu Wu, Jiaying Pan, Yupeng Hao, Ke Nie, Li Yu, Yumeng Zhu, Xiangyi Zhao, Kai Huang, Mengke Zhang, Yongyan Zhao, Yaping Jiang, Siyuan Wang, Yiling Pan, Yubing Chen, Yilai Lin, Wanghong Shi, Yayuan Deng, Jin Han, Jie Li, Xuan Long, Junbin Wang, Zhiyuan Zhang, Zegang Han, Zhanfeng Si, Lei Ju, Jun Li, Tianzhen Zhang, Ji Zhou, Xueying Guan   +32 more
wiley   +1 more source

Exploring reduced pulmonary exacerbation rates in cystic fibrosis: a pandemic or modulator effect? [PDF]

ERJ Open Res
Stephenson AL, Sykes J, Stanojevic S, Ma X, Ostrenga J, Todd J, Faro A, Elbert A, Marshall B, Ramos KJ, Cromwell E, Quon BS, Goss CH, Somayaji R.   +13 more
europepmc   +1 more source

Layer‐Dependent Phonon Polaritons in hBN Resolved by Photo‐Induced Force Spectroscopy

Advanced Science, EarlyView.
Layer‐dependent phonon polariton resonances in hexagonal boron nitride are systematically investigated using photo‐induced force microscopy. The in‐plane resonance exhibits a blueshift, while the out‐of‐plane resonance shows a redshift with increasing thickness. These results establish layer number as a key parameter for tuning polaritonic responses in
Amin Hajarian, Jiwoo Seo, SungWoo Nam
wiley   +1 more source

Clinician-accessible automated machine learning in oral healthcare: A systematic review. [PDF]

Jpn Dent Sci Rev
Shujaat S, Riaz M, Almutairi H, Alanazi H, Altalhi L, Alenazi N, Bin Osayl H, Philip MR, Aboalela AA, Ma H.   +9 more
europepmc   +1 more source

Interacting Parallel Fluidic Hysterons

Advanced Science, EarlyView.
The parallel coupling of fluidic hysterons is introduced, establishing advanced functionalities in inflatable soft systems. A pressure–volume framework reveals how preset volumes Δv∗${\Delta }v^*$ tune nonlinear interactions between hysterons and actuation sequences without changing architecture. Experiments validate the predictions, opening new routes
Katrien Stinissen, Franco Nicolas Piñan Basualdo, Benjamin Gorissen   +2 more
wiley   +1 more source

Electrical Impedance Myography Detects Disease Progression over 12 to 24 Months in Facioscapulohumeral Muscular Dystrophy. [PDF]

Ann Neurol
Mul K, McDermott MP, Butterfield RJ, Elsheikh B, Eichinger K, Johnson NE, Leung DG, LoRusso S, Lewis L, Martens WB, Shieh PB, Wang LH, Walker M, Tawil R, Statland JM, ReSolve Investigators of the FSHD‐CTRN.   +15 more
europepmc   +1 more source

Targeting the HSPA8‐CMA‐ATP6V1A Axis Triggers Lysosomal Hyperacidification and Catastrophic Vacuolation in Prostate Cancer

Advanced Science, EarlyView.
Our experimental evidence supports a model in which ALO targets the HSPA8‐CMA‐ATP6V1A axis to induce lysosomal hyperacidification and initiate osmotic and lipidomic stress. These changes are associated with LMP and loss of lysosomal integrity in prostate cancer cells.
Bingzheng An, Ze Gao, Shuo Chen, Liwei Meng, Chen Zhang, Kefan Song, Haochen Cui, Lei Yan, Zhiqing Fang   +8 more
wiley   +1 more source

Two-Year Progressive Cranial Changes Following the Melbourne Technique for Sagittal Craniosynostosis. [PDF]

Cleft Palate Craniofac J
Harrison LM, Prezelski K, Hallac RR, Kane AA, Sanati-Mehrizy P.   +4 more
europepmc   +1 more source