Results 31 to 40 of about 683,357 (240)
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Experimental Study on Interface Model of Asphalt Pavement under Vertical Load
Applied Sciences, 2022 Layered asphalt pavement makes the interlayer contact more complicated. In order to further understand the characteristics of interlayer interface of asphalt pavement under vehicle load, this paper analyzes the change rule of interlayer interface of ...
Jie Yu +4 more
doaj +1 more source
Geometrically nonlinear analysis of thin-walled composite box beams [PDF]
, 2008 A general geometrically nonlinear model for thin-walled composite space beams with arbitrary lay-ups under various types of loadings has been presented by using variational formulation based on the classical lamination theory.
Bathe +23 more
core +1 more source
Load-Bearing Performance of a Reinforced Fill Structure with Pile Penetration
Applied SciencesReinforcement soil slope with pile penetration is a new load bearing structure, which has a complex working mechanism, but few studies have been carried out. This paper aims to investigate the stability characteristics of this structure using model tests.
Qiang Ma +3 more
doaj +1 more source
Load-settlement behaviour of model pile groups in sand under vertical load
Journal of Civil Engineering and Management, 2017 Model pile load testing is effective to study the load-settlement behaviour of pile foundations given the controlled environment in which the testing is done. This paper reports a testing program in a large calibration chamber involving individual piles
Mauricio Martines Sales +4 more
doaj +1 more source
Model Test and Back Analysis of Shield Tunnel Load Distribution in Soft Clay
Advances in Materials Science and Engineering, 2021 Combined with the soft clay layer of Foshan metro, a back-analysis method combining model test and numerical simulation is developed. First, the similitude criterion for the model used in this study was derived from similarity theory and elasticity ...
Haoshuang Niu +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
BuildingsColumn frames connected using Tang Dynasty straight tenon joints represent a unique structural system characterized by historical significance and architectural ingenuity.
Xiang Gan +8 more
doaj +1 more source