Results 31 to 40 of about 2,215,344 (291)

Stresses induced by vertical rectangular uniform loads within ground based on Mindlin solution

Yantu gongcheng xuebao, 2018
The calculation of foundation settlement is usually based on the Boussinesq’s solution or Mindlin’s solution, which is suitable for considering the embedding depth to calculate the additional stress coefficient.
HE Chun-bao , WANG Lin-bin , LI Gao-yang
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Load-Bearing Performance of a Reinforced Fill Structure with Pile Penetration

Applied Sciences
Reinforcement soil slope with pile penetration is a new load bearing structure, which has a complex working mechanism, but few studies have been carried out. This paper aims to investigate the stability characteristics of this structure using model tests.
Qiang Ma, Hanlong Yu, Yicong Yang, Lei Xi   +3 more
doaj   +1 more source

Experimental Study on Interface Model of Asphalt Pavement under Vertical Load

Applied Sciences, 2022
Layered asphalt pavement makes the interlayer contact more complicated. In order to further understand the characteristics of interlayer interface of asphalt pavement under vehicle load, this paper analyzes the change rule of interlayer interface of ...
Jie Yu, Gang Cheng, Yong Zheng, Tong Zeng, Xinhe Hu   +4 more
doaj   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

Safety Analysis on Thread of Test String in High Pressure and High Production Gas Wells

Shiyou jixie, 2022
At present, the researchs on the mechanics of test string mainly focus on the buckling deformation of test string under various loads such as internal pressure, external pressure, axial force, torque, bending moment and viscous friction, but the analysis
Mao Liangjie, Zhang Xiaocheng, Dai Qing, Xia Dongqing, Zhang Pengxiang   +4 more
doaj  

Model Test and Back Analysis of Shield Tunnel Load Distribution in Soft Clay

Advances in Materials Science and Engineering, 2021
Combined with the soft clay layer of Foshan metro, a back-analysis method combining model test and numerical simulation is developed. First, the similitude criterion for the model used in this study was derived from similarity theory and elasticity ...
Haoshuang Niu, Xiaolin Weng, Chao Tian, Deng Wang   +3 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Research on the Lateral Resistance of Column Frames in the Tang Dynasty: A Case Study of the Straight Tenon Joints Under Varied Vertical Load Levels

Buildings
Column frames connected using Tang Dynasty straight tenon joints represent a unique structural system characterized by historical significance and architectural ingenuity.
Xiang Gan, Fanxu Kong, Ziyi Wang, Xinran Li, Tingyu Meng, Jiayang Wang, Qin Wang, Jinqiu Xie, Zeli Que   +8 more
doaj   +1 more source