Results 41 to 50 of about 2,215,344 (291)

Capacity of grillage foundations under horizontal loading [PDF]

, 2012
Grillage foundations are an alternative to solid surface mudmats for supporting seabed infrastructure, offering improved hydrodynamic performance and savings in foundation material.
Egborge, R., Knappett, J. A.; id_orcid, Brown, M. J.; id_orcid, Yun, G., Morgan, N., Cathie, D., Brown, N., Maconochie, A., Ripley, A. G., Bransby, M. F., Hudacsek, P.   +10 more
core   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Design of a load carriage system oriented to reduce acceleration forces when carrying a backpack

Revista Facultad de Ingeniería Universidad de Antioquia, 2020
In military life, load carriage is an unavoidable part of field operations which is the reason why soldiers often make use of a military backpack. Infantry soldiers usually carry loads weighting more than 30% of their body weight.
Camilo Eduardo Pérez-Cualtán, Oscar Iván Campo-Salazar   +1 more
doaj   +1 more source

Impact Loadings on Vertical Walls in Directional Seas

Coastal Engineering 1998, 1999
Recent research under PROVERBS has demonstrated that wave impact loads can cause damage or failure of caisson or blockwork breakwaters. Research studies of wave loadings, pulsating or impact, have generally used only 2 - dimensional wave flume experiments, and so most design methods are strongly biased towards 2-d .
N. W. H. Allsop, CALABRESE, MARIO
openaire   +3 more sources

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Evaluation of Changes in Soil Compaction Due to the Passage of Combine Harvester

Acta Universitatis Agriculturae et Silviculturae Mendelianae Brunensis, 2016
This paper concerns the results of changes in soil compaction after the passages of combine harvester. The research was done on the maize-stubble; the soil was the mold formed in the sand.
Martin Svoboda, Marek Brennensthul, Jiří Pospíšil   +2 more
doaj   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

Liquefaction Potential of Silty Sand Surrounding A Bucket Foundation Under Vertical Vibration Load

, 2012
To study the liquefaction potential of sand surrounding bucket foundations, centrifuge experiments were carried out. Results have shown that the sand layer around a bucket foundation softens or liquefies under vertical dynamic load when the load ...
Zhang XH(张旭辉), 鲁晓兵, Lu XB(鲁晓兵), Jiao BT(矫滨田)   +3 more
core   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source