Results 61 to 70 of about 10,030,532 (260)
Evolution‐guided yeast complementation reveals functional differences in human PSPH variants
FEBS Open Bio, EarlyView.Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez +6 more
wiley +1 more source
Vertical Integration in the Presence of Upstream Competition [PDF]
We analyze vertical integration in the case of upstream competition and compare outcomes to the case where upstream assets are owned by a single agent (i.e., upstream monopoly).
Catherine C. de Fontenay, Joshua S. Gans
core +2 more sources
Protocol for quantifying miRNA trafficking across the endosomal membrane
FEBS Open Bio, EarlyView.An in vitro protocol measures miRNA uptake into endosomes isolated from mammalian cell extracts, which are free of subcellular contaminants. Performed at 37 °C in the presence of ATP, it ensures the import of single‐stranded miRNA into the endosomal lumen.
Syamantak Ghosh +2 more
wiley +1 more source
The C‐terminal domain of yeast Arginyltransferase1 is essential for its catalytic activity
FEBS Open Bio, EarlyView.Arginyltransferase 1 (Ate1), a eukaryotic enzyme, catalyses arginylation, transferring arginine from tRNA‐Arg to the amino terminus of the target protein. Overexpression of Ate1 in yeast is lethal and is dependent on arginylation. This study elucidates how mutations in the cofactor‐binding and active site of Ate1 and truncation of its structural ...
Vikas Kumar Yadav +4 more
wiley +1 more source
Entry and Vertical Disintegration [PDF]
We formalize and extend George Stigler’s famous article “The division of labor is limited by the extent of the market.” We emphasize economies of scale in intermediate goods production as a determinant of firm boundaries and vertical control.
Christiaan Hogendorn, Alain de Fontenay
core
Anticompetitive Vertical Merger Waves [PDF]
, 2013 We develop a model of vertical merger waves leading to input foreclosure. When all upstream firms become vertically integrated, the input price can increase substantially above marginal cost despite Bertrand competition in the input market.
Schutz, Nicolas +2 more
core +1 more source
Behavior of Expansive Clay of Ngawi Region (East Java) Under Water Content Variation
Civil Engineering Dimension, 2009 When expansive clay is wetted, deformations occur both vertically and laterally. If it is tested in an oedometer ring apparatus the lateral deformation will be restrained by the wall of the ring.
Indrasurya B Mochtar +3 more
doaj
BuildingsVertical greening systems, in addition to enhancing the aesthetic design of building facades, contribute to energy saving and carbon reduction. This study proposes a simplified calculation method for the annual comprehensive carbon reduction potential of
Hongtu Mi +3 more
doaj +1 more source
FEBS Open Bio, EarlyView.This pilot study investigates the potential of Generative AI to provide formative feedback to students. ChatGPT was prompted to provide feedback on Year 1 Bioscience essays, which were evaluated against established good feedback practices. GenAI‐authored feedback had useful elements, but was limited in scope. GenAI may have potential to provide instant,
Annabel Court +3 more
wiley +1 more source
Vertical Integration, Innovation and Foreclosure [PDF]
This paper studies the potential effects of vertical integration on downstream firms' incentives to innovate. Interacting efficiently with a supplier may require information exchanges, which raises the concern that sensitive information may be disclosed ...
Marie-Laure Allain +2 more
core