Results 51 to 60 of about 681,079 (267)

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Pathogenicity, tissue tropism and potential vertical transmission of SARSr-CoV-2 in Malayan pangolins.

PLoS Pathogens, 2023
Malayan pangolin SARS-CoV-2-related coronavirus (SARSr-CoV-2) is closely related to SARS-CoV-2. However, little is known about its pathogenicity in pangolins.
Xianghui Liang, Xiaoyuan Chen, Junqiong Zhai, Xiaobing Li, Xu Zhang, Zhipeng Zhang, Ping Zhang, Xiao Wang, Xinyuan Cui, Hai Wang, Niu Zhou, Zu-Jin Chen, Renwei Su, Fuqing Zhou, Edward C Holmes, David M Irwin, Rui-Ai Chen, Qian He, Ya-Jiang Wu, Chen Wang, Xue-Qing Du, Shi-Ming Peng, Wei-Jun Xie, Fen Shan, Wan-Ping Li, Jun-Wei Dai, Xuejuan Shen, Yaoyu Feng, Lihua Xiao, Wu Chen, Yongyi Shen   +30 more
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Is HAM/3 (hydrogenic atoms in molecules, version 3) a semiempirical version of dft (density functional theory) for ionization processes?

Journal of the Brazilian Chemical Society, 2004
We calculated valence-electron vertical ionization potentials (VIPs) of nine small molecules, plus uracil and C2F4, by several different methods: semiempirical HAM/3 and AM1 methods, different nonempirical DFT models such as uDI(B88-P86)/cc-pVTZ and ...
Takahata Yuji, Chong Delano P., Segala Maxmiliano   +2 more
doaj  

A methodological tool for sustainability and feasibility assessment of indoor vertical farming with artificial lighting in Africa

Scientific Reports, 2023
African agriculture is bound to face challenges for its future food systems development and economic transformation. Indoor vertical farms with artificial lighting represent an opportunity that has been gaining relevance worldwide, thanks to their ...
Ivan Paucek, Emanuele Durante, Giuseppina Pennisi, Stefania Quaini, Giorgio Gianquinto, Francesco Orsini   +5 more
doaj   +1 more source

Vertices and the CJT Effective Potential

, 1993
The Cornwall-Jackiw-Tomboulis effective potential is modified to include a functional dependence on the fermion-gauge particle vertex, and applied to a quark confining model of chiral symmetry breaking.
openaire   +2 more sources

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

Light use efficiency of lettuce cultivation in vertical farms compared with greenhouse and field

Food and Energy Security, 2023
Vertical farming is a relatively new fresh fruit and vegetable production system, where lamps (mostly light emitting diodes [LED]) are the sole light source.
Wenqing Jin, David Formiga Lopez, Ep Heuvelink, Leo F. M. Marcelis   +3 more
doaj   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Measuring the Milky Way Vertical Potential with the Phase Snail in a Model-independent Way

The Astrophysical Journal
The vertical phase-space spiral (snail) is a direct sign of disequilibrium of the Milky Way’s disk. Nevertheless, the wrapping of the phase snail contains information on the vertical potential.
Rui Guo, Zhao-Yu Li, Juntai Shen, Shude Mao, Chao Liu   +4 more
doaj   +1 more source