Results 41 to 50 of about 10,030,532 (260)

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

A Multi-Site NFV Testbed for Experimentation With SUAV-Based 5G Vertical Services

IEEE Access, 2020
With the advent of 5G technologies, vertical markets have been placed at the forefront, as fundamental drivers and adopters of technical developments and new business models.
Ivan Vidal, Borja Nogales, Francisco Valera, Luis F. Gonzalez, Victor Sanchez-Aguero, Eduardo Jacob, Cristina Cervello-Pastor   +6 more
doaj   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Eccentricity samples: Implications on the potential and the velocity distribution [PDF]

Serbian Astronomical Journal, 2017
Planar and vertical epicycle frequencies and local angular velocity are related to the derivatives up to the second order of the local potential and can be used to test the shape of the potential from stellar disc samples.
Cubarsi R., Stojanović M., Ninković S.
doaj   +1 more source

The vertical light-gradient and its potential impact on animal distribution and behavior

Frontiers in Ecology and Evolution, 2022
The visual environment provides vital cues allowing animals to assess habitat quality, weather conditions or measure time of day. Together with other sensory cues and physiological conditions, the visual environment sets behavioral states that make the ...
Dan-E Nilsson, Jochen Smolka, Michael Bok   +2 more
doaj   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Liquefaction Potential of Silty Sand Surrounding A Bucket Foundation Under Vertical Vibration Load

, 2012
To study the liquefaction potential of sand surrounding bucket foundations, centrifuge experiments were carried out. Results have shown that the sand layer around a bucket foundation softens or liquefies under vertical dynamic load when the load ...
Zhang XH(张旭辉), 鲁晓兵, Lu XB(鲁晓兵), Jiao BT(矫滨田)   +3 more
core   +1 more source

Evaluation of the celestial bodies influence on gravity field

Geodesy and Cartography, 2012
Influence of the celestial bodies on gravity field is analysed in this article. It is necessary to take into account this influence while making precise geodetic, gravimetric and astronomical measurements, defining sites coordinates of the Earth’s ...
Petras  Petroškevičius, Darius  Popovas   +1 more
doaj   +1 more source