Results 221 to 230 of about 945,119 (285)

Soluble Nanomedicine Against Soluble Neurosensitizers to Effectively Relieve Osteoarthritis Pain and Joint Damage

Exploration, EarlyView.
Osteoarthritis pain arises not only from joint damage but also from inflammation, abnormal bone changes, and excessive nerve activation inside the joint. In this study, we developed an injectable nanomedicine, LAC, that responds to the acidic environment of osteoarthritic joints to locally release two approved drugs, reducing inflammation, limiting ...
Junyan Liu, Feixiang Ding, Jiayi Li, Min Liu, Lingyu Su, Zixi Wang, Congying Pi, Shilong Jiang, Zhaokui Zeng, Changjun Li, Chao Zeng, Guanghua Lei, Kelong Ai   +12 more
wiley   +1 more source

Probing Solution Dynamics of Tissue Factor Using Molecular Dynamics Simulations Guided by NMR Chemical Shifts. [PDF]

J Phys Chem B
Lihan M, Pant S, Ojoawo AM, Rienstra CM, Tajkhorshid E.   +4 more
europepmc   +1 more source

Deep red to near‐infrared thermally activated delayed fluorescence conjugated polymers toward highly efficient solution‐processible deep red and near‐infrared organic light‐emitting diodes

FlexMat, EarlyView.
A series of deep red (DR) and near‐infrared (NIR) thermally activated delayed fluorescence conjugated polymers are prepared, their solution‐processible organic light‐emitting diodes exhibit DR emission with maximum external quantum efficiency (EQEmax) of 6.4%, high luminance of 4254 cd m−2 and emission peak at 678 nm, and a NIR device with EQEmax of 2 ...
Tao Wang, Hongyang Zhang, Liping Jin, Peng Tao, Yanxiang Cheng, Wai‐Yeung Wong   +5 more
wiley   +1 more source

Elucidation of the mechanism of partial activation of EPAC1 allosteric modulators by Markov state modelling. [PDF]

Chem Sci
Hardie A, Powell FG, Lovera S, Yarwood SJ, Barker G, Michel J.   +5 more
europepmc   +1 more source

Recent advances and prospects for high‐efficiency blue hot exciton organic light‐emitting diodes

FlexMat, EarlyView.
Blue organic light‐emitting diodes (OLEDs) face great challenges in achieving the balance between color purity, device efficiency, and stability. Hot exciton materials offer a solution by rapidly converting non‐emissive triplet excitons into singlet ones through a high‐lying reverse intersystem crossing process.
Xiaoen Shi, Shuyuan Ge, Futong Liu, Ping Lu   +3 more
wiley   +1 more source

Accurate interdomain contacts in a mixed folded protein from NMR-guided coarse-grained simulations.

Phys Chem Chem Phys
Hobbs B, Limmer N, Clenshaw GL, Ossa F, Karamanos TK.   +4 more
europepmc   +1 more source

Damping amyloid-associated conformational fluctuations in a protein by an engineered diselenide bridge. [PDF]

Protein Sci
Yang Y, Dhayalan B, Ehnbom A, Weil-Ktorza O, Metanis N, Weiss MA.   +5 more
europepmc   +1 more source

Engineering an artificial trachea: Quantitative benchmarks and modular strategies for mechanics, epithelialization, and vascular integration

FlexMat, EarlyView.
In this work, we first examine the limitations of surgical repair and stenting, including migration, granulation, mucus plugging, and infection. We then translate these failures into engineering constraints involving geometry, mechanics, fixation, degradation, junctional stress, and remodeling.
Yiwei Xu, Hanqing Dai, Qianwang Ye, Wanlu Zhang, Na Wang, Lei Xiong, Ruiqian Guo   +6 more
wiley   +1 more source

Adaptation to Stress Switches Stress-Evoked Network Disconnection to a New Forebrain Network State. [PDF]

eNeuro
Durieux L, Bourdy R, Herbeaux K, Totah NK, Lecourtier L.   +4 more
europepmc   +1 more source