Results 101 to 110 of about 290,721 (306)

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

FEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara, Kinga Skoczek, Elzbieta Pyza, Milena Damulewicz   +3 more
wiley   +1 more source

The Ca2+ sensor protein Swiprosin-1/EFhd2 is present in neurites and involved in kinesin-mediated transport in neurons

, 2014
This work was supported by grants from the German Science Foundation (Deutsche Forschungsgemeinschaft, DFG; FOR832, to DM), the German Federal Ministry of Education and Research (01GQ113; to BW), the Bavarian Ministry of Sciences, Research and the Arts ...
Oliver Welzel, Böhm, Konrad J., Fritsch, K, Regensburger, M, Winner, B, Dirk Mielenz, Brachs, Sebastian, Regensburger, Martin, Francesc Perez-Branguli, Iryna Prots, Perez-Branguli , F, Eva Borger, Loy, Kristina, Brachs, S, Buslei, R, Wenzel, EM, Borger, Eva, Gromer, TW, Mielenz, Dirk, Max Holzer, Beate Winner, Kristina Loy, Holzer, M, Purohit, Pavitra, Holzer, Max, Purohit, P, Buslei, Rolf, Welzel, Oliver, Gunn-Moore, Frank J, Kristin Fritsch, Eva Maria Wenzel, Frank Gunn-Moore, Mielenz, D, Konrad J Böhm, Rolf Buslei, Loy, K, Teja W Grömer, Bohm, KJ, Fritsch, Kristin, Pavitra Purohit, Wenzel, Eva Maria, Prots, I, Perez-Branguli, Francesc, Gunn-Moore, Frank, Welzel, O, Prots, Iryna, Grömer, Teja W., Winner, Beate, Sebastian Brachs, Martin Regensburger   +49 more
core   +1 more source

Vesicle-associated membrane protein 5 is an intrinsic defense factor for embryonic stem cells against coronaviruses

Nature Communications
Embryonic stem cells (ESCs) display a distinctive resistance against various viruses, irrespective of any interferon response. Nevertheless, the underlying mechanism of this resistance remains unclear.
Huijun Dong, Zihang Pan, Pengtao Jiao, Fei Ye, Qi Peng, Yanying Yu, Xinyuan Lai, Huan Li, Zhao Guan, Juan Deng, Tao Shen, Wenjie Tan, Yi Shi, Qiang Ding, Jianyuan Luo, Tong Li, Hui Zhuang, Kuanhui Xiang   +17 more
doaj   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

A novel 4.1 ezrin radixin moesin (FERM)-containing protein, 'Willin' [PDF]

, 2005
The 4.1 superfamily of proteins contain a 4.1 Ezrin Radixin Moesin (FERM) domain and are described as linking the cytoskeleton with the plasma membrane. Here, we describe a new FERM domain-containing protein called Willin.
Guild, Simon, Lissa R. Herron, Brophy, Peter J, Prystowsky, Michael B., Margaret Brandwein-Gensler, Michael B. Prystowsky, Gavin I. Welsh, Gunn-Moore, Frank J., Venkateswarlu, Kanamarlapudi, Tavaré, Jeremy M, Tavaré, Jeremy M., Gunn-Moore, Francis James, Frank J. Gunn-Moore, Tavaré, JM, Herron, Lissa R, Herron, Lissa R., Gillespie, Stewart, Brannigan, Frances, Prystowsky, M, Stewart Gillespie, Prystowsky, Michael B, Welsh, Gavin I., Frances Brannigan, Tavare, J, Welsh, Gavin I, Welsh, GI, Prystowsky, MB, Kanamarlapudi Venkateswarlu, Brophy, P, Herron, LR, Simon Guild, Brandwein-Gensler, M, Madan, R, Peter J. Brophy, Gunn-Moore, FJ, Gillespie, S, Brophy, Peter J., Rashna Madan, Brannigan, F, Welsh, G, Gunn-Moore, Frank J, Brandwein-Gensler, Margaret, Venkateswarlu, K, Guild, S, Madan, Rashna, Jeremy M. Tavaré, Brophy, PJ, Herron, L, Venkat Kanamarlapudi   +48 more
core   +1 more source

Huntingtin-associated protein 1 plays an essential role in the pathogenesis of type 2 diabetes by regulating the translocation of GLUT4 in mouse adipocytes

BMJ Open Diabetes Research & Care, 2020
Objective Glucose disposal by insulin-responsive tissues maintains the body glucose homeostasis and insulin resistance leads to a risk of developing type 2 diabetes (T2DM).
Yan-Ju Gong, Ying Feng, Yuan-Yuan Cao, Jia Zhao, Ya-Yun Zheng, Jia-Rui Wu, Gui-Zhi Yang   +6 more
doaj   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Negative regulation of syntaxin4/SNAP-23/VAMP2-mediated membrane fusion by Munc18c In Vitro [PDF]

, 2008
Background: Translocation of the facilitative glucose transporter GLUT4 from an intracellular store to the plasma membrane is responsible for the increased rate of glucose transport into fat and muscle cells in response to insulin.
Nia J Bryant, Gould, G.W., Veronica Aran, James A McNew, Gwyn W Gould, McNew, J.A., Bryant, N.J., Aran Veronica, Avani Verma, Gould Gwyn W., Aran-Ponte, V., Fiona M Brandie, Bryant Nia J., Verma Avani, Brandie Fiona M., McNew James A., Brandie, F.M., Verma, A.   +17 more
core   +1 more source

Botulinum Neurotoxin F Subtypes Cleaving the VAMP-2 Q58–K59 Peptide Bond Exhibit Unique Catalytic Properties and Substrate Specificities

Toxins, 2018
In the recent past, about 40 botulinum neurotoxin (BoNT) subtypes belonging to serotypes A, B, E, and F pathogenic to humans were identified among hundreds of independent isolates.
Stefan Sikorra, Martin Skiba, Martin B. Dorner, Jasmin Weisemann, Mirjam Weil, Sylvia Valdezate, Bazbek Davletov, Andreas Rummel, Brigitte G. Dorner, Thomas Binz   +9 more
doaj   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source