Results 81 to 90 of about 102,829,138 (255)

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

Bacterial outer membrane vesicles and vaccine applications [PDF]

, 2014
Vaccines based on outer membrane vesicles (OMV) were developed more than 20 years ago against Neisseria meningitidis serogroup B. These nano-sized structures exhibit remarkable potential for immunomodulation of immune responses and delivery of “self ...
Sarmiento, Maria Elena, Campa, Concepcion, Fernandez, Sonsire, Garcia, Luis, Cardoso, Daniel, Zayas, Caridad, Rosenqvist, Einar, Ferro, Valerie, Acosta, Armando, Acevedo, Reinaldo, Perez, Jose Luis   +10 more
core   +3 more sources

Rare Autism-Associated Variants Implicate Syntaxin 1 (STX1 R26Q) Phosphorylation and the Dopamine Transporter (hDAT R51W) in Dopamine Neurotransmission and Behaviors

EBioMedicine, 2015
Background: Syntaxin 1 (STX1) is a presynaptic plasma membrane protein that coordinates synaptic vesicle fusion. STX1 also regulates the function of neurotransmitter transporters, including the dopamine (DA) transporter (DAT).
Etienne Cartier, Peter J. Hamilton, Andrea N. Belovich, Aparna Shekar, Nicholas G. Campbell, Christine Saunders, Thorvald F. Andreassen, Ulrik Gether, Jeremy Veenstra-Vanderweele, James S. Sutcliffe, Paula G. Ulery-Reynolds, Kevin Erreger, Heinrich J.G. Matthies, Aurelio Galli   +13 more
doaj   +1 more source

Optimization of seminal extracellular vesicle isolation protocols for cancer biomarker analysis using proteomic profiling

Molecular Oncology, EarlyView.
This paper shows that size‐exclusion chromatography and sequential centrifugation applied to seminal plasma enrich for different populations of extracellular vesicles. This may significantly affect the detection and analysis of extracellular vesicle‐associated cancer biomarkers.
Elen Telumyan, Beatriz Martín‐Gracia, Eva Bassols‐Citores, Krizia Sagini, Maria K. Andersen, Tuula A. Nyman, May‐Britt Tessem, Morten B. Rye, Alicia Llorente   +8 more
wiley   +1 more source

Tumour‐proximal deep serum proteomics identifies biomarkers associated with ovarian cancer

Molecular Oncology, EarlyView.
New biomarkers are needed for early ovarian cancer detection. Ovarian (tumour‐proximal) and peripheral vein serum from healthy women and patients with benign or malignant tumours underwent nanoparticle‐enriched deep proteomics. Ovarian serum yielded more protein identifications and revealed tumour‐reflective signatures.
Darren Lau, Daniel Pincher, Clifford Young, Nicholas Chappell, Noor A. Lokman, Parul Mittal, Leigh Donnellan, Martin K. Oehler, Doug A. Brooks, Peter Hoffmann   +9 more
wiley   +1 more source

The Ca2+ sensor protein Swiprosin-1/EFhd2 is present in neurites and involved in kinesin-mediated transport in neurons [PDF]

, 2014
This work was supported by grants from the German Science Foundation (Deutsche Forschungsgemeinschaft, DFG; FOR832, to DM), the German Federal Ministry of Education and Research (01GQ113; to BW), the Bavarian Ministry of Sciences, Research and the Arts ...
Oliver Welzel, Böhm, Konrad J., Fritsch, K, Regensburger, M, Winner, B, Dirk Mielenz, Brachs, Sebastian, Regensburger, Martin, Francesc Perez-Branguli, Iryna Prots, Perez-Branguli , F, Eva Borger, Loy, Kristina, Brachs, S, Buslei, R, Wenzel, EM, Borger, Eva, Gromer, TW, Mielenz, Dirk, Max Holzer, Beate Winner, Kristina Loy, Holzer, M, Purohit, Pavitra, Holzer, Max, Purohit, P, Buslei, Rolf, Welzel, Oliver, Gunn-Moore, Frank J, Kristin Fritsch, Eva Maria Wenzel, Frank Gunn-Moore, Mielenz, D, Konrad J Böhm, Rolf Buslei, Loy, K, Teja W Grömer, Bohm, KJ, Fritsch, Kristin, Pavitra Purohit, Wenzel, Eva Maria, Prots, I, Perez-Branguli, Francesc, Gunn-Moore, Frank, Welzel, O, Prots, Iryna, Grömer, Teja W., Winner, Beate, Sebastian Brachs, Martin Regensburger, Fritsch Kristin, Prots Iryna, Gunn-Moore Frank, Purohit Pavitra, Winner Beate, Buslei Rolf, Borger Eva, Grömer Teja W., Mielenz Dirk, Holzer Max, Brachs Sebastian, Regensburger Martin, Loy Kristina, Perez-Branguli Francesc, Welzel Oliver, Böhm Konrad J., Wenzel Eva Maria, Borger, Eva; id_orcid, Gunn-Moore, Frank J; id_orcid   +68 more
core   +2 more sources

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

The Sec1/Munc18 protein Vps45 regulates cellular levels of its SNARE binding partners Tlg2 and Snc2 in Saccharomyces cerevisiae [PDF]

, 2012
Intracellular membrane trafficking pathways must be tightly regulated to ensure proper functioning of all eukaryotic cells. Central to membrane trafficking is the formation of specific SNARE (soluble N-ethylmeleimide-sensitive factor attachment protein ...
Marion S Struthers, Nia J Bryant, Lindsay N Carpp, Carpp Lindsay N., Shanks, S.G., McCann Rebecca K., Carpp, L.N., Struthers, M.S., Bryant, N.J., Scott G Shanks, Struthers Marion S., McCann, R.K., Bryant Nia J., Hong, W., Shanks Scott G., Rebecca K McCann   +15 more
core   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

CSE1L/CAS, the cellular apoptosis susceptibility protein, enhances invasion and metastasis but not proliferation of cancer cells

Journal of Experimental & Clinical Cancer Research, 2008
Background The cellular apoptosis susceptibility (CAS) protein is regarded as a proliferation-associated protein that associates with tumour proliferation as it associates with microtubule and functions in the mitotic spindle checkpoint.
Chen Ying-Chun, Lin Chuang-Yu, Li Li-Tzu, Luo Shue-Fen, Liao Ching-Fong, Jiang Ming-Chung   +5 more
doaj   +1 more source