Results 71 to 80 of about 290,721 (306)

Pancreatic Acinar Cells Express Vesicle-associated Membrane Protein 2- and 8-Specific Populations of Zymogen Granules with Distinct and Overlapping Roles in Secretion [PDF]

Journal of Biological Chemistry, 2007
Previous studies have demonstrated roles for vesicle-associated membrane protein 2 (VAMP 2) and VAMP 8 in Ca(2+)-regulated pancreatic acinar cell secretion, however, their coordinated function in the secretory pathway has not been addressed. Here we provide evidence using immunofluorescence microscopy, cell fractionation, and SNARE protein interaction ...
Ning, Weng, Diana D H, Thomas, Guy E, Groblewski   +2 more
openaire   +2 more sources

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Effect of Resveratrol Supplementation on the SNARE Proteins Expression in Adipose Tissue of Stroptozotocin-Nicotinamide Induced Type 2 Diabetic Rats

Iranian Journal of Medical Sciences, 2015
Background: Glucose uptake by muscles and fat cells is carried out by the GLUT4 system. Isoforms of the SNAP23, syntaxin-4 and VAMP-2 play an important role in regulating GLUT-4 trafficking and fusion in adipocytes.
Azam Rezaei Farimani, Massoud Saidijam, Mohammad Taghi Goodarzi, Reza Yadegar Azari, Soheila Asadi, Sadegh Zarei, Nooshin Shabab   +6 more
doaj  

High Temperature Disrupts Organelle Distribution and Functions Affecting Meiotic Maturation in Porcine Oocytes

Frontiers in Cell and Developmental Biology, 2022
Heat stress (HS) has been known to cause reproductive failure in animals, especially in summer. HS severely affects the developmental potential of oocytes and leads to low fertility rates.
Song-Hee Lee, Ming-Hong Sun, Dongjie Zhou, Wen-Jie Jiang, Xiao-Han Li, Geun Heo, Xiang-Shun Cui   +6 more
doaj   +1 more source

Presence of a Complex Containing Vesicle-associated Membrane Protein 2 in Rat Parotid Acinar Cells and Its Disassembly upon Activation of cAMP-dependent Protein Kinase [PDF]

Journal of Biological Chemistry, 1999
Amylase release from parotid acinar cells is mainly induced by the accumulation of intracellular cAMP, presumably through the phosphorylation of substrates by cAMP-dependent protein kinase (PKA). However, the molecular mechanisms of this process are not clear.
J, Fujita-Yoshigaki, Y, Dohke, M, Hara-Yokoyama, S, Furuyama, H, Sugiya   +4 more
openaire   +2 more sources

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Controlled delivery of membrane proteins to artificial lipid bilayers by nystatin-ergosterol modulated vesicle fusion

, 2006
The study of ion channels and other membrane proteins and their potential use as biosensors and drug screening targets require their reconstitution in an artificial membrane.
Fisher, K.H., Berry, RM, Fisher, K H, Berry, R M, de Planque, MR, de Planque, M R R, Sandison, ME, Watts, A, Mendes, G P, Morgan, Hywel, Watts, A., Berry, Richard, Sandison, M E, de Planque, M.R.R., Sandison, Mairi E., Mendes, GP, Zagnoni, M, Zagnoni, Michele, Watts, Anthony, Berry, R.M., Morgan, H, Mendes, G.P., Fisher, KH   +22 more
core   +1 more source

Correction: The Endocytic Adaptor Eps15 Controls Marginal Zone B Cell Numbers. [PDF]

, 2013
Eps15 is an endocytic adaptor protein involved in clathrin and non-clathrin mediated endocytosis. In Caenorhabditis elegans and Drosophila melanogaster lack of Eps15 leads to defects in synaptic vesicle recycling and synapse formation. We generated Eps15-
Eckhard Wolf, Pier Paolo Di Fiore, Treise, Irina, Helmut Fuchs, Offenhäuser, Nina, Simona Ronzoni, Thure Adler, Irina Treise, Betsholtz, Christer, Di Fiore, Pier Paolo, Busch, Dirk H., Martin Hrabě de Angelis, Lucano, Caterina, Amodio, Stefania, Adler, Thure, Caterina Lucano, Nina Offenhäuser, Betsholtz, Ingrid Holmberg, Rathkolb, Birgit, Pozzi, Benedetta, Daniela Castelletti, Castelletti, Daniela, Dirk H. Busch, Anna Sciullo, Ingrid Holmberg Betsholtz, Ronzoni, Simona, Christer Betsholtz, Stefano Casola, Birgit Rathkolb, Benedetta Pozzi, Sciullo, Anna, Fuchs, Helmut, Wolf, Eckhard, Gailus-Durner, Valérie, Hrabé de Angelis, Martin, Valérie Gailus-Durner, Casola, Stefano, Stefania Amodio   +37 more
core   +1 more source

Mannogalactoglucan from mushrooms protects pancreatic islets via restoring UPR and promotes insulin secretion in T1DM mice

Food Science and Human Wellness
Type 1 diabetes mellitus (T1DM) lacks insulin secretion due to autoimmune deficiency of pancreatic β-cells. Protecting pancreatic islets and enhancing insulin secretion has been therapeutic approaches.
Ting Liu, Si Chen, Yunhe Qu, Lujuan Zheng, Xiaoxuan Yang, Shuhan Men, Yuanning Wang, Hanrui Ma, Yifa Zhou, Yuying Fan   +9 more
doaj   +1 more source

Postsynaptic VAMP/Synaptobrevin Facilitates Differential Vesicle Trafficking of GluA1 and GluA2 AMPA Receptor Subunits.

PLoS ONE, 2015
Vertebrate organisms adapt to a continuously changing environment by regulating the strength of synaptic connections between brain cells. Excitatory synapses are believed to increase their strength by vesicular insertion of transmitter glutamate ...
Suleman Hussain, Svend Davanger
doaj   +1 more source