Results 71 to 80 of about 102,829,138 (255)

Studies on muscular dystrophy associated genes [PDF]

, 2007
Muscular dystrophy is a collective group of genetic disorder that results in progressive wasting of skeletal muscle. Dysferlin, the gene responsible for Limb Girdle Muscular Dystrophy type 2B (LGMD2B) and Miyoshi Myopathy (MM) was found to be a member of
Bakir, Hadil
core  

Effect of Mutations in Vesicle-Associated Membrane Protein (VAMP) on the Assembly of Multimeric Protein Complexes

, 1997
The assembly of multimeric protein complexes that include vesicle-associated membrane protein 2 (VAMP-2) and the plasma membrane proteins syntaxin 1A and synaptosome-associated protein of 25 kDa (SNAP-25) are thought to reflect the biochemical correlates
Joe C. Hao, Natalie Salem, Regis B. Kelly, Mark K. Bennett, Xiao-Rong Peng   +4 more
core   +1 more source

Characterization of the protein import apparatus in isolated outer envelopes of chloroplasts [PDF]

, 1991
Isolated outer envelope membrane from pea (Pisum sativum L.) chloroplasts can be used in vitro to study binding and partial translocation of precursor proteins destined for the inside of the organelle.
Soll, Jürgen, Waegemann, Karin
core   +1 more source

Vesicle-associated membrane protein 5 is an intrinsic defense factor for embryonic stem cells against coronaviruses

Nature Communications
Embryonic stem cells (ESCs) display a distinctive resistance against various viruses, irrespective of any interferon response. Nevertheless, the underlying mechanism of this resistance remains unclear.
Huijun Dong, Zihang Pan, Pengtao Jiao, Fei Ye, Qi Peng, Yanying Yu, Xinyuan Lai, Huan Li, Zhao Guan, Juan Deng, Tao Shen, Wenjie Tan, Yi Shi, Qiang Ding, Jianyuan Luo, Tong Li, Hui Zhuang, Kuanhui Xiang   +17 more
doaj   +1 more source

A New Pathway Promotes Adaptation of Human Glioblastoma Cells to Glucose Starvation

Cells, 2020
Adaptation of glioblastoma to caloric restriction induces compensatory changes in tumor metabolism that are incompletely known. Here we show that in human glioblastoma cells maintained in exhausted medium, SHC adaptor protein 3 (SHC3) increases due to ...
Alberto Azzalin, Francesca Brambilla, Eloisa Arbustini, Katia Basello, Attilio Speciani, Pierluigi Mauri, Paola Bezzi, Lorenzo Magrassi   +7 more
doaj   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

The Emp24 complex recruits a specific cargo molecule into endoplasmic reticulum-derived vesicles [PDF]

, 2000
Members of the yeast p24 family, including Emp24p and Erv25p, form a heteromeric complex required for the efficient transport of selected proteins from the endoplasmic reticulum (ER) to the Golgi apparatus.
Muñiz Guinea, Manuel, Riezman, Howard, Howard Riezman, Claude Nuoffer, Nuoffer, Claude, Nuoffer, C., Riezman, H., Muniz, M., Hauri, Hans Peter, Manuel Muñiz, Hauri, H. P., Hans-Peter Hauri, Nuoffer C, Riezman H, Muñiz M, Hauri HP   +15 more
core   +1 more source

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

Molecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani, Dominic Guanzon, Andrew Lai, Katherin Scholz‐Romero, Sarah Reed, Edita Ritmejeryte, Rohan Lourie, Naven Chetty, Kaltin Ferguson, Carlos Salomon   +9 more
wiley   +1 more source

Botulinum Neurotoxin F Subtypes Cleaving the VAMP-2 Q58–K59 Peptide Bond Exhibit Unique Catalytic Properties and Substrate Specificities

Toxins, 2018
In the recent past, about 40 botulinum neurotoxin (BoNT) subtypes belonging to serotypes A, B, E, and F pathogenic to humans were identified among hundreds of independent isolates.
Stefan Sikorra, Martin Skiba, Martin B. Dorner, Jasmin Weisemann, Mirjam Weil, Sylvia Valdezate, Bazbek Davletov, Andreas Rummel, Brigitte G. Dorner, Thomas Binz   +9 more
doaj   +1 more source

Huntingtin-associated protein 1 plays an essential role in the pathogenesis of type 2 diabetes by regulating the translocation of GLUT4 in mouse adipocytes

BMJ Open Diabetes Research & Care, 2020
Objective Glucose disposal by insulin-responsive tissues maintains the body glucose homeostasis and insulin resistance leads to a risk of developing type 2 diabetes (T2DM).
Yan-Ju Gong, Ying Feng, Yuan-Yuan Cao, Jia Zhao, Ya-Yun Zheng, Jia-Rui Wu, Gui-Zhi Yang   +6 more
doaj   +1 more source