Results 61 to 70 of about 290,721 (306)

Vesicle-associated Membrane Protein 2 Plays a Specific Role in the Insulin-dependent Trafficking of the Facilitative Glucose Transporter GLUT4 in 3T3-L1 Adipocytes [PDF]

Journal of Biological Chemistry, 1998
Vesicle-associated membrane protein 2 (VAMP2) has been implicated in the insulin-regulated trafficking of GLUT4 in adipocytes. It has been proposed that VAMP2 co-localizes with GLUT4 in a postendocytic storage compartment (Martin, S., Tellam, J., Livingstone, C., Slot, J. W., Gould, G. W., and James, D. E. (1996) J. Cell Biol. 134, 625-635), suggesting
Martin, Laura B., Shewan, Annette, Millar, Caroline A., Gould, Gwyn W., James, David E.   +4 more
openaire   +5 more sources

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Fluctuation Imaging of LRRK2 Reveals that the G2019S Mutation Alters Spatial and Membrane Dynamics

Molecules, 2020
Mutations within the Leucine-Rich Repeat Kinase 2 (LRRK2) gene are the most common genetic cause of autosomal and sporadic Parkinson’s disease (PD).
Bethany J. Sanstrum, Brandee M. S. S. Goo, Diana Z. Y. Holden, Donovan D. Delgado, Thien P. N. Nguyen, Kiana D. Lee, Nicholas G. James   +6 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

β-microglobulin amyloid fibril-induced membrane disruption is enhanced by endosomal lipids and acidic pH [PDF]

, 2014
Although the molecular mechanisms underlying the pathology of amyloidoses are not well understood, the interaction between amyloid proteins and cell membranes is thought to play a role in several amyloid diseases. Amyloid fibrils of β-microglobulin (βm),
Eric W. Hewitt, Xue, W-F, Beales Paul A., Sheynis, T, Radford, SE, Neil A. Ranson (610030), Sheena E. Radford (197775), Beales, Paul A, Goodchild Sophia C., Thompson, Rebecca, Xue Wei-Feng, Neil A. Ranson, Thompson Rebecca, Sheena E Radford, Sophia C. Goodchild, Sheynis Tania, Eric W Hewitt, Kevin W. Tipping (610028), Radford Sheena E., Tipping Kevin W., Sheena E. Radford, Hewitt, EW, Xue, Wei-Feng, Beales, PA, Radford, Sheena E, Tipping, KW, Sophia C Goodchild, Paul A Beales, Goodchild, SC, Ranson, Neil A, Rebecca Thompson, Wei-Feng Xue (610029), Ranson Neil A., Neil A Ranson, Tipping, Kevin W, Tania Sheynis (610026), Kevin W Tipping, Tania Sheynis, Sheynis, Tania, Wei-Feng Xue, Goodchild, Sophia C, Eric W. Hewitt (197779), Hewitt, Eric W, Hewitt Eric W., Sophia C. Goodchild (283440), Ranson, NA, Rebecca Thompson (610027), Paul A. Beales (435545), Thompson, R, Paul A. Beales   +49 more
core   +1 more source

MAHRP2 is required for tether formation and cytoadherence in Plasmodium falciparum infected red blood cells

Frontiers in Cellular and Infection Microbiology
The ability of the human malaria parasite Plasmodium falciparum to remodel its host red blood cell (RBC) is central to the parasite’s ability to survive within the circulation of its host and cause disease.
Mohini A. Shibu, Mohini A. Shibu, Gerald J. Shami, Eric Hanssen, Eric Hanssen, Olivia M. S. Carmo, Vineet Vaibhav, Vineet Vaibhav, Jumana Yousef, Jumana Yousef, Laura F. Dagley, Laura F. Dagley, James McCarthy, James McCarthy, Matthew W. A. Dixon, Matthew W. A. Dixon   +15 more
doaj   +1 more source

The Effect of Albumin on MRP2 and BCRP in the Vesicular Transport Assay.

PLoS ONE, 2016
The ABC transporters multidrug resistance associated protein 2 (MRP2) and breast cancer resistance protein (BCRP) are of interest in drug development, since they affect the pharmacokinetics of several drugs.
Feng Deng, Noora Sjöstedt, Heidi Kidron
doaj   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Integration of a virus membrane protein into the lipid bilayer of target cells as a prerequisite for immune cytolysis [PDF]

, 1979
Structural requirements for membrane antigens on target cells to mediate immune cytolysis were studied in a model system with purified membrane proteins from Semliki Forest virus (SFV). These SFV spike proteins were isolated in the form of detergent- and
Schirrmacher, V., B Morein, V Schirrmacher, Koszinowski, Ulrich H., Morein, B., D Barz, Barz, D., U Koszinowski   +7 more
core   +1 more source

Inter-channel scaffolding of presynaptic CaV2.2 via the C terminal PDZ ligand domain

Biology Open, 2013
Summary Calcium entry through CaV2.2 calcium channels clustered at the active zone (AZ) of the presynaptic nerve terminal gates synaptic vesicle (SV) fusion and the discharge of neurotransmitters, but the mechanism of channel scaffolding remains poorly ...
Sabiha R. Gardezi, Qi Li, Elise F. Stanley   +2 more
doaj   +1 more source