Requirement of Cholesterol for Calcium‐Dependent Vesicle Fusion by Strengthening Synaptotagmin‐1‐Induced Membrane Bending [PDF]
Advanced Science, 2023 Cholesterol is essential for neuronal activity and function. Cholesterol depletion in the plasma membrane impairs synaptic transmission. However, the molecular mechanisms by which cholesterol deficiency leads to defects in vesicle fusion remain poorly ...
Houda Yasmine Ali Moussa +6 more
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The machinery of vesicle fusion. [PDF]
Curr Opin Cell Biol, 2023 The compartmentalization of eukaryotic cells is reliant on the fidelity of vesicle-mediated intracellular transport. Vesicles deliver their cargo via membrane fusion, a process requiring membrane tethers, Sec1/Munc18 (SM) proteins, and SNAREs. These components function in concert to ensure that membrane fusion is efficient and accurate, but the ...
Stanton AE, Hughson FM.
europepmc +3 more sources
Vesicle trafficking and vesicle fusion: mechanisms, biological functions, and their implications for potential disease therapy [PDF]
Molecular Biomedicine, 2022 Intracellular vesicle trafficking is the fundamental process to maintain the homeostasis of membrane-enclosed organelles in eukaryotic cells. These organelles transport cargo from the donor membrane to the target membrane through the cargo containing ...
Lele Cui +9 more
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Cooperative inhibition of SNARE-mediated vesicle fusion by α-synuclein monomers and oligomers [PDF]
Scientific Reports, 2021 The primary hallmark of Parkinson's disease (PD) is the generation of Lewy bodies of which major component is α-synuclein (α-Syn). Because of increasing evidence of the fundamental roles of α-Syn oligomers in disease progression, α-Syn oligomers have ...
Gyeongji Yoo +4 more
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Single-vesicle intensity and colocalization fluorescence microscopy to study lipid vesicle fusion, fission, and lipid exchange [PDF]
Frontiers in Molecular Neuroscience, 2022 Interactions of lipid vesicles play important roles in a large variety of functions and dysfunctions in the human body. Vital for several biochemical functions is the interaction between monomeric proteins and lipid membranes, and the induced phenomena ...
Alexandra Andersson +6 more
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Quantification of Giant Unilamellar Vesicle Fusion Products by High-Throughput Image Analysis. [PDF]
Int J Mol Sci, 2023 Caliari A +4 more
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Dynamics of Neuromuscular Transmission Reproduced by Calcium-Dependent and Reversible Serial Transitions in the Vesicle Fusion Complex. [PDF]
Front Synaptic Neurosci, 2021 Martínez-Valencia A +2 more
europepmc +3 more sources
ELAPOR1 is a copper-dependent tethering factor driving proacrosomal vesicle fusion during acrosome biogenesis. [PDF]
Proc Natl Acad Sci U S AShao T +7 more
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Ca<sup>2+</sup>/calmodulin and protein kinase C (PKC) reverse the vesicle fusion arrest by unmasking PIP<sub>2</sub>. [PDF]
Sci AdvMoussa HYA, Shin KC, Park Y.
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Vesicle Cholesterol Controls Exocytotic Fusion Pore [PDF]
SSRN Electronic Journal, 2021 In some lysosomal storage diseases (LSD) cholesterol accumulates in vesicles. Whether increased vesicle cholesterol affects vesicle fusion with the plasmalemma, where the fusion pore, a channel between the vesicle lumen and the extracellular space, is formed, is unknown.
Rituper, Boštjan +17 more
openaire +4 more sources