Results 101 to 110 of about 1,227,442 (389)

Huntingtin is required for ER-to-Golgi transport and for secretory vesicle fusion at the plasma membrane

Disease Models & Mechanisms, 2014
Huntingtin is a large membrane-associated scaffolding protein that associates with endocytic and exocytic vesicles and modulates their trafficking along cytoskeletal tracks. Although the progression of Huntington’s disease is linked to toxic accumulation
H. Brandstaetter, A. Kruppa, F. Buss
semanticscholar   +1 more source

CNS Mitochondria‐Derived Vesicle in Blood: Potential Biomarkers for Brain Mitochondria Dysfunction

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Mitochondrial dysfunction is a hallmark of neurodegenerative diseases like Alzheimer's (AD) and Parkinson's (PD). Our goal was to develop practical, noninvasive methods to assess mitochondrial status through the detection of mitochondria‐derived vesicles (MDVs).
Qi Liu, Wentao Chen, Yahong Wu, Zhen Guo, Jun Chen, Chen Tian, Pan Wang, Shaopeng Zeng, Bin Xu, Jing Duan, Shilong Han, Xiao Xiong, Jing Zhang   +12 more
wiley   +1 more source

A novel synaptic vesicle fusion path in the rat cerebral cortex: the "saddle" point hypothesis. [PDF]

PLoS ONE, 2014
We improved freeze-fracture electron microscopy to study synapses in the neuropil of the rat cerebral cortex at ∼2 nm resolution and in three-dimensions.
Guido A Zampighi, Raul Serrano, Julio L Vergara   +2 more
doaj   +1 more source

Determining the neurotransmitter concentration profile at active synapses [PDF]

, 2009
Establishing the temporal and concentration profiles of neurotransmitters during synaptic release is an essential step towards understanding the basic properties of inter-neuronal communication in the central nervous system.
A Barberis, A Scimemi, A Tao, A Triller, AE Spruce, AG Ogston, AI Gulyas, AM Aravanis, Annalisa Scimemi, AV Hill, B Barbour, B Ceccarelli, B Granseth, B Katz, C Auger, C Nicholson, C Nicholson, C Nicholson, C Racca, D Colquhoun, D Colquhoun, D Sulzer, DA Rusakov, DE Bergles, DM Kullmann, DR Copenhagen, E Betzig, E Neher, E Sykova, EL Botvinick, EN Pothos, EP Huang, F Asztely, F Pouille, G Brasnjo, G Liu, G Szapiro, G Tong, GH Acheson, GH Patterson, H Korn, H Korn, H Shroff, HC Hartzell, IM Raman, J Balaji, J Castillo Del, J Hrabe, J Matthews-Bellinger, J Szabadics, JC Eccles, JC Eccles, JC Eccles, JD Clements, JE Heuser, JH Singer, JI Wadiche, JI Wadiche, JJ Celentano, JM Bekkers, JM Christie, JM Fernandez, JR Stiles, JS Diamond, JS Diamond, JS Diamond, JW Mozrzymas, JW Mozrzymas, K Belaya, K Krnjevic, K Luby-Phelps, K Zheng, KA Foster, KE Sorra, KL Magleby, KM Franks, KP Lehre, L He, L Tao, LG Longsworth, LM Levy, LM Wahl, LP Savtchenko, LS Overstreet, M Beato, M Beato, M Beato, MA Medina, Marco Beato, MI Banks, MJ Higley, MV Jones, MY Min, N Arnth-Jensen, N Harata, N Riveros, NC Harata, O Prange, P Fatt, P Fatt, P Legendre, PJ Kruk, PM Burger, Q Zhang, Q Zhang, R Ando, R Conti, R Renden, R Ventura, RG Thorne, RH Chow, RM Wightman, RW Daniels, RY Tsien, S Habuchi, S Hrabetova, S Manley, S Namiki, S Okumoto, S Takamori, SA Hires, SJ Pitt, SP Gandhi, SW Kuffler, SY Breusegem, T Lu, T Schikorski, T Schikorski, TA Nielsen, TG Allen, TG Banke, TG Oertner, TM Bartol Jr, V Burzomato, VA Levin, W Almers, W Lu, X Chen, XS Wu, Y Dehnes, Y Takumi, YH Huang, Z Nusser, Z Petrasek, Z Petrasek   +144 more
core   +2 more sources

Fusion of Sulfatide‐Containing Vesicles of Phosphatidylcholine [PDF]

European Journal of Biochemistry, 1983
Positively charged albumin is described as a ‘useful tool’ to induce both aggregation and fusion of phosphatidylcholine vesicles containing sulfatide. Techniques that include light‐scattering, Sepharose chromatography, centrifugation, electron microscopy, trapped volume determination and scanning calorimetry demonstrate that extensive fusion occurs ...
Giuliano Pizzini, Livia Barenghi, Giovanna Cervato, Elvira Pistolesi, Benvenuto Cestaro   +4 more
openaire   +3 more sources

Activation of SIRT1 Reduces Renal Tubular Epithelial Cells Fibrosis in Hypoxia Through SIRT1‐FoxO1‐FoxO3‐Autophagy Pathway

Advanced Biology, EarlyView.
Hypoxia promotes the epithelial‐mesenchymal transition (EMT) of renal tubular epithelial cells via the SIRT1‐FoxO1‐FoxO3‐autophagy pathway, thereby resulting in the fibrosis of renal tubular epithelial cells. Activation of SIRT1 or induction of autophagy inhibits this process, alleviating hypoxia‐induced fibrosis.
Guangyu Wang, Lijuan Zhang, Jiaorong Tan, Fei Li, Yishan Jin, Limei He, Xin Yang   +6 more
wiley   +1 more source

Intracellular Vesicle Fusion Requires a Membrane-Destabilizing Peptide Located at the Juxtamembrane Region of the v-SNARE

Cell Reports, 2019
Summary: Intracellular vesicle fusion is mediated by soluble N-ethylmaleimide sensitive factor attachment protein receptors (SNAREs) and Sec1/Munc18 (SM) proteins. It is generally accepted that membrane fusion occurs when the vesicle and target membranes
Shailendra S. Rathore, Yinghui Liu, Haijia Yu, Chun Wan, MyeongSeon Lee, Qian Yin, Michael H.B. Stowell, Jingshi Shen   +7 more
doaj  

Gli2a protein localization reveals a role for Iguana/DZIP1 in primary ciliogenesis and a dependence of Hedgehog signal transduction on primary cilia in the zebrafish [PDF]

, 2010
Background: In mammalian cells, the integrity of the primary cilium is critical for proper regulation of the Hedgehog (Hh) signal transduction pathway.
Ingham, P.W., Kim, H.R., Richardson, J., van Eeden, F.   +3 more
core   +3 more sources

A molecular toggle after exocytosis sequesters the presynaptic syntaxin1a molecules involved in prior vesicle fusion

Nature Communications, 2014
Neuronal synapses are among the most scrutinized of cellular systems, serving as a model for all membrane trafficking studies. Despite this, synaptic biology has proven difficult to interrogate directly in situ due to the small size and dynamic nature of
D. Kavanagh, A. M. Smyth, Kirsty J. Martin, Alison R. Dun, E. Brown, S. Gordon, K. J. Smillie, L. Chamberlain, R. Wilson, Lei Yang, W. Lu, M. Cousin, C. Rickman, R. Duncan   +13 more
semanticscholar   +1 more source

The Potential for Extracellular Vesicles in Nanomedicine: A Review of Recent Advancements and Challenges Ahead

Advanced Biology, EarlyView.
Extracellular vesicles (EVs) play a dual role in diagnostics and therapeutics, offering innovative solutions for treating cancer, cardiovascular, neurodegenerative, and orthopedic diseases. This review highlights EVs’ potential to revolutionize personalized medicine through specific applications in disease detection and treatment.
Farbod Ebrahimi, Anjali Kumari, Samaneh Ghadami, Saqer Al Abdullah, Kristen Dellinger   +4 more
wiley   +1 more source