Results 11 to 20 of about 1,227,442 (389)
The machinery of vesicle fusion. [PDF]
Curr Opin Cell Biol, 2023 The compartmentalization of eukaryotic cells is reliant on the fidelity of vesicle-mediated intracellular transport. Vesicles deliver their cargo via membrane fusion, a process requiring membrane tethers, Sec1/Munc18 (SM) proteins, and SNAREs. These components function in concert to ensure that membrane fusion is efficient and accurate, but the ...
Stanton AE, Hughson FM.
europepmc +3 more sources
The Mechanisms of Vesicle Budding and Fusion [PDF]
Cell, 2004 Genetic and biochemical analyses of the secretory pathway have produced a detailed picture of the molecular mechanisms involved in selective cargo transport between organelles. This transport occurs by means of vesicular intermediates that bud from a donor compartment and fuse with an acceptor compartment.
J. Bonifacino, B. Glick
semanticscholar +3 more sources
Nature Structural & Molecular Biology, 2008 The core of the neurotransmitter release machinery is formed by SNARE complexes, which bring the vesicle and plasma membranes together and are key for fusion, and by Munc18-1, which controls SNARE-complex formation and may also have a direct role in fusion.
Christian Rosenmund, Josep Rizo
openaire +3 more sources
Synaptotagmin 1 oligomers clamp and regulate different modes of neurotransmitter release [PDF]
, 2020 Release of neurotransmitters relies on submillisecond coupling of synaptic vesicle fusion to the triggering signal: AP-evoked presynaptic Ca2+ influx.
Bello, Oscar D. +9 more
core +3 more sources
Disorders of synaptic vesicle fusion machinery
Journal of Neurochemistry, 2020 The revolution in genetic technology has ushered in a new age for our understanding of the underlying causes of neurodevelopmental, neuromuscular and neurodegenerative disorders, revealing that the presynaptic machinery governing synaptic vesicle fusion ...
Holly Melland, Elysa Carr, S. Gordon
semanticscholar +1 more source
Atomic-resolution simulations predict a transition state for vesicle fusion defined by contact of a few lipid tails. [PDF]
PLoS Computational Biology, 2010 Membrane fusion is essential to both cellular vesicle trafficking and infection by enveloped viruses. While the fusion protein assemblies that catalyze fusion are readily identifiable, the specific activities of the proteins involved and nature of the ...
Peter M Kasson +2 more
doaj +1 more source
Synergistic roles of Synaptotagmin-1 and complexin in calcium-regulated neuronal exocytosis
eLife, 2020 Calcium (Ca2+)-evoked release of neurotransmitters from synaptic vesicles requires mechanisms both to prevent un-initiated fusion of vesicles (clamping) and to trigger fusion following Ca2+-influx. The principal components involved in these processes are
Sathish Ramakrishnan +4 more
doaj +1 more source
Shape transformations of lipid vesicles by insertion of bulky-head lipids [PDF]
, 2015 Lipid vesicles, in particular Giant Unilamellar Vesicles (GUVs), have been increasingly important as compartments of artificial cells to reconstruct living cell-like systems in a bottom-up fashion.
Fujii, Satoshi +4 more
core +12 more sources
Genome-wide identification, phylogeny and expression profile of vesicle fusion components in Verticillium dahliae. [PDF]
PLoS ONE, 2013 Vesicular trafficking plays a crucial role in protein localization and movement, signal transduction, and multiple developmental processes in eukaryotic cells.
Xue Yang +5 more
doaj +1 more source
Individual Vesicle-Vesicle and Vesicle-Planar Bilayer Fusion Events Mediated by DNA [PDF]
Biophysical Journal, 2011 We have previously reported that DNA-lipid conjugates, when inserted into lipid vesicles, can mediate interactions between vesicles such as docking and fusion∗. These DNA-mediated interactions are a model for the biological machinery (SNARE proteins) employed in synaptic vesicle fusion. We can also use DNA-lipids to build model membrane platforms, such
Bob J. Rawle +4 more
openaire +2 more sources