Results 21 to 30 of about 131,357 (307)
Disorders of synaptic vesicle fusion machinery [PDF]
Journal of Neurochemistry, 2020 AbstractThe revolution in genetic technology has ushered in a new age for our understanding of the underlying causes of neurodevelopmental, neuromuscular and neurodegenerative disorders, revealing that the presynaptic machinery governing synaptic vesicle fusion is compromised in many of these neurological disorders. This builds upon decades of research
Holly Melland +2 more
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Cell Reports, 2019 Summary: Intracellular vesicle fusion is mediated by soluble N-ethylmaleimide sensitive factor attachment protein receptors (SNAREs) and Sec1/Munc18 (SM) proteins. It is generally accepted that membrane fusion occurs when the vesicle and target membranes
Shailendra S. Rathore +7 more
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Fusion Pore Diameter Regulation by Cations Modulating Local Membrane Anisotropy
The Scientific World Journal, 2012 The fusion pore is an aqueous channel that is formed upon the fusion of the vesicle membrane with the plasma membrane. Once the pore is open, it may close again (transient fusion) or widen completely (full fusion) to permit vesicle cargo discharge. While
Doron Kabaso +5 more
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Actin and Myosin in Non-Neuronal Exocytosis
Cells, 2020 Cellular secretion depends on exocytosis of secretory vesicles and discharge of vesicle contents. Actin and myosin are essential for pre-fusion and post-fusion stages of exocytosis.
Pika Miklavc, Manfred Frick
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Calcium dependence of neurotransmitter release at a high fidelity synapse
eLife, 2021 The Ca2+-dependence of the priming, fusion, and replenishment of synaptic vesicles are fundamental parameters controlling neurotransmitter release and synaptic plasticity.
Abdelmoneim Eshra +3 more
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Cells, 2018 Vesicle fusion is a fundamental cell biological process similar from yeasts to humans. For secretory vesicles, swelling is considered a step required for the expulsion of intravesicular content.
Mariangela Centrone +12 more
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Acta Biologica Slovenica, 2009 Vesicles are cellular organelles, in which signaling molecules (neurotransmitters or hormones) are stored and are essential for the function of neurons and endocrine cells in supporting the communication between tissues and organs.
Nina Vardjan +4 more
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New insights into the control of secretion
Communicative & Integrative Biology, 2009 Vesicular secretion is a fundamental process in the body with vesicle fusion releasing vesicle contents to the outside. This process, called exocytosis, is usually thought of as leading to an all-or-none release of content; regulation of secretory output
Peter Thorn
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Frontiers in Molecular Biosciences, 2021 The fusion pore is the initial narrow connection that forms between fusing membranes. During vesicular release of hormones or neurotransmitters, the nanometer-sized fusion pore may open-close repeatedly (flicker) before resealing or dilating irreversibly,
Joerg Nikolaus +12 more
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Alpha-Synuclein Continues to Enhance SNARE-Dependent Vesicle Docking at Exorbitant Concentrations
Frontiers in Neuroscience, 2019 Recently, Parkinson’s disease-associated α-synuclein (αS) has emerged as an important regulator for SNARE-dependent vesicle fusion. However, it is controversial if excessive accumulation of αS, even in the absence of aggregation, impairs ...
Brenden J. D. Hawk +2 more
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