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Mechanics of post-fusion exocytotic vesicle
Physical Biology, 2017Exocytosis is an important cellular process controlled by metabolic signaling. It involves vesicle fusion to the plasma membrane, followed by the opening of a fusion pore, and the subsequent release of the vesicular lumen content into the extracellular space.
Thomas Stephens, Zhanghan Wu, Jian Liu
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Studying the Effects of Inositol Pyrophosphates in an In Vitro Vesicle–Vesicle Fusion Assay
2019In a recent in vitro vesicle fusion study in which we monitored the fusion of reconstituted SNARE and synaptotagmin-containing proteoliposomes, we discovered that inositol pyrophosphate (5-IP7) is a potent inhibitor of neuronal exocytosis. We found that the inhibitory effect of 5-IP7, which is 10 times more potent than those of IP6 and 1-IP7, requires ...
Mi Sook Sung +2 more
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Photocontorollable fusion of lipid vesicles
2015 International Symposium on Micro-NanoMechatronics and Human Science (MHS), 2015The behavior of lipid vesicles in the presence of a photosensitive surfactant was studied. We found that UV irradiation induces the change in membrane tension and causes the fusion of vesicles. We discuss the physical mechanism of this fusion event in terms of the elastic free energy of the membrane.
Y. Suzuki +4 more
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Aggregation and fusion of phospholipid vesicles
Progress in Surface Science, 1983Membrane fusion and aggregation of phospholipid vesicles are reviewed and discussed. The fusion process is viewed as consisting of several stages: aggregation and close apposition of the particles, destabilization, and finally, merging of the bilayers.
Jan Wilschut +3 more
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Fusion pore regulation in peptidergic vesicles
Cell Calcium, 2012Regulated exocytosis, which involves fusion of secretory vesicles with the plasma membrane, is an important mode of communication between cells. In this process, signalling molecules that are stored in secretory vesicles are released into the extracellular space.
Marko Kreft +3 more
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SNARE-mediated vesicle navigation, vesicle anatomy and exocytotic fusion pore
Cell Calcium, 2018The focus of this special issue (SI) »Membrane Merger in Conventional and Unconventional Vesicle Secretion« is regulated exocytosis, a universally conserved mechanism, consisting of a merger between the vesicle and the plasma membranes. Although this process evolved with eukaryotic organisms some three billion years ago (Spang et al., 2015), the ...
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Promotion and inhibition of vesicle fusion by polylysine
Biochemistry, 1985Polylysine induced rapid aggregation of large unilamellar vesicles composed of phosphatidylcholine-cardiolipin (1:1 molar ratio) but not their fusion. Application of the terbium-dipicolinic acid fusion assay showed that addition of polylysine at nanomolar concentrations enabled a significant lowering of the Ca2+ threshold concentration for vesicle ...
Hava Weinberg +4 more
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Vesicle fusion and fission in plants and yeast
Cell Calcium, 2017Measurements of the membrane capacitance on animal cells has provided an excellent technique for monitoring of exo- and endocytotic activity in intact living cells. Here we review recent data in which the same technique was applied to plant cells and cells of the budding yeast Saccharomyces cerevisiae.
Adam Bertl +3 more
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Fusion pore stability of peptidergic vesicles
Molecular Membrane Biology, 2010It is believed that in regulated exocytosis the vesicle membrane fuses with the plasma membrane in response to a physiological stimulus. However, in the absence of stimulation, repetitive transient fusion events are also observed, reflecting a stable state. The mechanisms by which the initial fusion pore attains stability are poorly understood.
Veronika Kralj-Iglič +8 more
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Control of vesicle fusion by a tyrosine phosphatase
Nature Cell Biology, 2004The tyrosine phosphatase PTP-MEG2 is targeted by its amino-terminal Sec14p homology domain to the membrane of secretory vesicles. There it regulates vesicle size by promoting homotypic vesicle fusion by a mechanism that requires its catalytic activity.
William S. Trimble +16 more
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