Results 41 to 50 of about 1,227,442 (389)

Models of synaptotagmin‐1 to trigger Ca2+‐dependent vesicle fusion

FEBS Letters, 2018
Vesicles in neurons and neuroendocrine cells store neurotransmitters and peptide hormones, which are released by vesicle fusion in response to Ca2+‐evoking stimuli.
Yongsoo Park, Je-Kyung Ryu
semanticscholar   +1 more source

Lipid-Anchored SNAREs Lacking Transmembrane Regions Fully Support Membrane Fusion during Neurotransmitter Release [PDF]

, 2013
SummarySynaptic vesicle fusion during neurotransmitter release is mediated by assembly of SNARE- and SM-protein complexes composed of syntaxin-1, SNAP-25, synaptobrevin-2/VAMP2, and Munc18-1.
Bacaj, Taulant, Pang, Zhiping P., Südhof, Thomas C., Yang, Xiaofei, Zhou, Peng   +4 more
core   +1 more source

Otoferlin acts as a Ca2+ sensor for vesicle fusion and vesicle pool replenishment at auditory hair cell ribbon synapses

eLife, 2017
Hearing relies on rapid, temporally precise, and sustained neurotransmitter release at the ribbon synapses of sensory cells, the inner hair cells (IHCs).
Nicolas Michalski, J. Goutman, S. Auclair, J. Boutet de Monvel, Margot Tertrais, Alice Emptoz, Alexandre Parrin, Sylvie Nouaille, M. Guillon, M. Sachse, D. Ciric, Amel Bahloul, J. Hardelin, R B Sutton, P. Avan, Shyam S. Krishnakumar, J. Rothman, D. Dulon, S. Safieddine, C. Petit   +19 more
semanticscholar   +1 more source

Fusion Properties of Gliotransmitter Vesicles in Astrocytes [PDF]

Biophysical Journal, 2014
Astrocytes, the most abundant type of glial cells, play a number of important functions in information processing in the brain. They ensheath synapses and modulate synaptic transmission by many mechanisms which include the exocytotic release of gliotransmitters into the extracellular space.
Gucek, Alenka, Jorgacevski, Jernej, Singh, Priyanka, Geisler, Claudia, Rituper, Bostjan, Vardjan, Nina, Kreft, Marko, Egner, Alexander, Hell, Stefan W., Zorec, Robert   +9 more
openaire   +3 more sources

Mechanisms of Exocytosis

Acta Biologica Slovenica, 2009
Vesicles are cellular organelles, in which signaling molecules (neurotransmitters or hormones) are stored and are essential for the function of neurons and endocrine cells in supporting the communication between tissues and organs.
Nina Vardjan, Matjaž Stenovec, Jernej Jorgačevski, Marko Kreft, Robert Zorec   +4 more
doaj   +1 more source

Transmembrane tethering of synaptotagmin to synaptic vesicles controls multiple modes of neurotransmitter release [PDF]

, 2014
Synaptotagmin 1 (Syt1) is a synaptic vesicle integral membrane protein that regulates neurotransmitter release by activating fast synchronous fusion and suppressing slower asynchronous release.
Lee, Jihye, Littleton, J. Troy
core   +1 more source

Understanding the formation of supported lipid bilayers via vesicle fusion-A case that exemplifies the need for the complementary method approach (Review).

Biointerphases, 2016
In this review, the authors discuss the challenges of studying supported lipid bilayers (SLBs) deposited by vesicle fusion in terms of (1) evaluating SLB formation and quality using quartz crystal microbalance with dissipation and (2) analyzing the ...
T. Lind, M. Cárdenas
semanticscholar   +1 more source

The role of myosin 1c and myosin 1b in surfactant exocytosis [PDF]

, 2016
Actin and actin-associated proteins have a pivotal effect on regulated exocytosis in secretory cells and influence pre-fusion as well as post-fusion stages of exocytosis.
Almeida, Barylko, Boguslavsky, Bond, Bose, Bose, Brandstaetter, Cai, Chen, Chinthalapudi, Coudrier, Crawley, Cyr, Czech, Dietl, Dietl, Dietl, Dietl, Diglio, Dobbs, Eitzen, Fan, Fang, Frick, Frick, Gillespie, Giner, Greenberg, Greenberg, Haller, Hokanson, Hokanson, Jahn, Komaba, Kovárová, Laakso, Laakso, Lin, Malacombe, Manceva, Martin, Masedunskas, Mason, Mazerik, McConnell, Miklavc, Miklavc, Miklavc, Miklavc, Miklavc, Nemoto, Nightingale, Nightingale, Papadopulos, Porat-Shliom, Prospéri, Raposo, Ridsdale, Rizo, Rojo Pulido, Rooney, Ruppert, Salas-Cortes, Sarshad, Schmidt, Shimada, Shuman, Sokac, Sokac, Stauffer, Swanljung-Collins, Swanljung-Collins, Tang, Thorn, Toyoda, Várnai, Weixel, Woolner, Yu, Zeng, Zhu   +80 more
core   +1 more source

Studying calcium-triggered vesicle fusion in a single vesicle-vesicle content and lipid-mixing system [PDF]

Nature Protocols, 2012
This protocol describes a single vesicle-vesicle microscopy system to study Ca(2+)-triggered vesicle fusion. Donor vesicles contain reconstituted synaptobrevin and synaptotagmin-1. Acceptor vesicles contain reconstituted syntaxin and synaptosomal-associated protein 25 (SNAP-25), and they are tethered to a PEG-coated glass surface.
M. Kyoung, Yunxiang Zhang, Jiajie Diao, S. Chu, A. Brunger   +4 more
semanticscholar   +3 more sources

New insights into the control of secretion

Communicative & Integrative Biology, 2009
Vesicular secretion is a fundamental process in the body with vesicle fusion releasing vesicle contents to the outside. This process, called exocytosis, is usually thought of as leading to an all-or-none release of content; regulation of secretory output
Peter Thorn
doaj   +1 more source