Results 51 to 60 of about 1,227,442 (389)
Theory of tunable pH sensitive vesicles of anionic and cationic lipids or anionic and neutral lipids [PDF]
, 2001 The design of vesicles which become unstable at an easily tuned value of pH is of great interest for targeted drug delivery. We present a microscopic theory for two forms of such vesicles.
Bell +34 more
core +3 more sources
Phosphorylation of residues inside the SNARE complex suppresses secretory vesicle fusion
EMBO Journal, 2016 Membrane fusion is essential for eukaryotic life, requiring SNARE proteins to zipper up in an α‐helical bundle to pull two membranes together. Here, we show that vesicle fusion can be suppressed by phosphorylation of core conserved residues inside the ...
S. Malmersjö +11 more
semanticscholar +1 more source
Epigallocatechin gallate inhibits SNARE‐dependent membrane fusion by blocking trans‐SNARE assembly
FEBS Open Bio, 2022 Insulin secretion is a signal‐triggered process that requires membrane fusion between the secretory granules and plasma membrane in pancreatic β cells. The exocytosis of insulin is mediated by target‐soluble N‐ethylmaleimide sensitive factor attachment ...
Min Zhu +4 more
doaj +1 more source
Frontiers in Molecular Biosciences, 2021 The fusion pore is the initial narrow connection that forms between fusing membranes. During vesicular release of hormones or neurotransmitters, the nanometer-sized fusion pore may open-close repeatedly (flicker) before resealing or dilating irreversibly,
Joerg Nikolaus +12 more
doaj +1 more source
Actin coating and compression of fused secretory vesicles are essential for surfactant secretion - a role for Rho, formins and myosin II [PDF]
, 2012 Secretion of vesicular contents by exocytosis is a fundamental cellular process. Increasing evidence suggests that post-fusion events play an important role in determining the composition and quantity of the secretory output. In particular, regulation of
Albillos +61 more
core +1 more source
v-SNARE transmembrane domains function as catalysts for vesicle fusion
eLife, 2016 Vesicle fusion is mediated by an assembly of SNARE proteins between opposing membranes, but it is unknown whether transmembrane domains (TMDs) of SNARE proteins serve mechanistic functions that go beyond passive anchoring of the force-generating SNAREpin
Madhurima Dhara +10 more
semanticscholar +1 more source
Alpha-Synuclein Continues to Enhance SNARE-Dependent Vesicle Docking at Exorbitant Concentrations
Frontiers in Neuroscience, 2019 Recently, Parkinson’s disease-associated α-synuclein (αS) has emerged as an important regulator for SNARE-dependent vesicle fusion. However, it is controversial if excessive accumulation of αS, even in the absence of aggregation, impairs ...
Brenden J. D. Hawk +2 more
doaj +1 more source
Fusion of secretory vesicles isolated from rat liver [PDF]
, 1978 Secretory vesicles isolated from rat liver were found to fuse after exposure to Ca2+. Vescle fusion is characterized by the occurrence of twinned vesicles with a continuous cleavage plane between two vesicles in freeze-fracture electron microscopy.
A. Amsterdam +75 more
core +1 more source
MicroRNA exocytosis by large dense-core vesicle fusion
Scientific Reports, 2017 Neurotransmitters and peptide hormones are secreted into outside the cell by a vesicle fusion process. Although non-coding RNA (ncRNA) that include microRNA (miRNA) regulates gene expression inside the cell where they are transcribed, extracellular miRNA
Alican Gümürdü +6 more
semanticscholar +1 more source
eLife, 2017 The synaptic vesicle Ca2+ sensor Synaptotagmin binds Ca2+ through its two C2 domains to trigger membrane interactions. Beyond membrane insertion by the C2 domains, other requirements for Synaptotagmin activity are still being elucidated.
Z. Guan +5 more
semanticscholar +1 more source