Results 51 to 60 of about 131,357 (307)
MicroRNA Exocytosis by Vesicle Fusion in Neuroendocrine Cells
Frontiers in Endocrinology, 2017 MicroRNAs (miRNAs) are short non-coding RNAs that posttranscriptionally regulate gene expression inside the cell. Extracellular circulating miRNAs are also observed outside the cell, but their origin is poorly understood.
Yongsoo Park
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Molecular Mechanisms of Vesicle Fusion [PDF]
Biophysical Journal, 2009 We have performed large scale molecular dynamics simulations using coarse-grained lipid models to study the fusion of vesicles. Our earlier work showed that lipid tail splay played an important role in the first lipids to cross from one vesicle to another.
Stevens, Mark J., Mirijanian, Dina
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Vesicle transfer and cell fusion [PDF]
Cancer Biology & Therapy, 2011 Cell-cell fusion and vesicle-mediated transfer are fundamental biological processes that are emerging as novel mechanisms for re-programming cells in the tumor microenvironment. Both cell-cell fusion and intercellular transfer of vesicles (including microvesicles and exosomes) allow for the transfer of information among tumor cells, between tumor cells
T. Kevin Howcroft +3 more
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Molecular Oncology, EarlyView.A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath +13 more
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Aging differentially affects multiple aspects of vesicle fusion kinetics.
PLoS ONE, 2011 How fusion pore formation during exocytosis affects the subsequent release of vesicle contents remains incompletely understood. It is unclear if the amount released per vesicle is dependent upon the nature of the developing fusion pore and whether full ...
Mark P Zanin +3 more
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Exocytotic fusion pore under stress
Cell Stress, 2020 Exocytosis is a universal process of eukaryotic cells, consisting of fusion between the vesicle and the plasma membranes, leading to the formation of a fusion pore, a channel through which vesicle cargo exits into the extracellular space.
Helena Haque Chowdhury, Robert Zorec
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Room for Two: The Synaptophysin/Synaptobrevin Complex
Frontiers in Synaptic Neuroscience, 2021 Synaptic vesicle release is regulated by upwards of 30 proteins at the fusion complex alone, but disruptions in any one of these components can have devastating consequences for neuronal communication. Aberrant molecular responses to calcium signaling at
Dustin N. White, Michael H. B. Stowell
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Vesicle Tethers Promoting Fusion Machinery Assembly [PDF]
Developmental Cell, 2002 In a recent issue of the Journal of Cell Biology, Shorter et al. demonstrate that p115, a vesicle tethering protein, binds specific SNAREs, key components of the membrane fusion machinery, and uncover that this interaction promotes the assembly of the fusion machinery.
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Molecular Oncology, EarlyView.This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker +16 more
wiley +1 more source
Synaptic vesicle fusion: today and beyond
Nature Structural & Molecular Biology, 2019 Researchers working on synaptic vesicle fusion and neurotransmitter release share their views on the most interesting developments in their field and the challenges that lie ahead.
Brose, N. ; https://orcid.org/0000-0003-0938-8534 +15 more
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