Results 61 to 70 of about 1,227,442 (389)
Actin dynamics switches two distinct modes of endosomal fusion in yolk sac visceral endoderm cells
eLifeMembranes undergo various patterns of deformation during vesicle fusion, but how this membrane deformation is regulated and contributes to fusion remains unknown.
Seiichi Koike +6 more
doaj +1 more source
Stabilization of the SNARE Core by Complexin-1 Facilitates Fusion Pore Expansion
Frontiers in Molecular Biosciences, 2021 In the neuron, neurotransmitter release is an essential function that must be both consistent and tightly regulated. The continuity of neurotransmitter release is dependent in large part on vesicle recycling. However, the protein factors that dictate the
Josh Pierson, Yeon-Kyun Shin
doaj +1 more source
Frontiers in Cell and Developmental Biology, 2021 Impaired insulin release is a hallmark of type 2 diabetes and is closely related to chronically elevated glucose concentrations, known as “glucotoxicity.” However, the molecular mechanisms by which glucotoxicity impairs insulin secretion remain poorly ...
Guoyi Yang +9 more
doaj +1 more source
PLoS Genetics, 2017 Ciliopathies are human disorders caused by dysfunction of primary cilia, ubiquitous organelles involved in transduction of environmental signals such as light sensation in photoreceptors.
Irene Ojeda Naharros +7 more
semanticscholar +1 more source
Exocyst dynamics during vesicle tethering and fusion
Nature Communications, 2018 The exocyst is a conserved octameric complex that tethers exocytic vesicles to the plasma membrane prior to fusion. Exocyst assembly and delivery mechanisms remain unclear, especially in mammalian cells.
S. M. Ahmed +5 more
semanticscholar +1 more source
Palmitoylation of the synaptic vesicle fusion machinery [PDF]
Journal of Neurochemistry, 2009 AbstractThe fusion of synaptic vesicles with the pre‐synaptic plasma membrane mediates the secretion of neurotransmitters at nerve terminals. This pathway is regulated by an array of protein–protein interactions. Of central importance are the soluble NSF (N‐ethylmaleimide‐sensitive factor) attachment protein receptor (SNARE) proteins syntaxin 1 and ...
Prescott, Gerald R +3 more
openaire +4 more sources
α-Synuclein-induced deformation of small unilamellar vesicles
QRB Discovery, 2022 α-Synuclein is a small neuronal protein that reversibly associates with lipid membranes. The membrane interactions are believed to be central to the healthy function of this protein involved in synaptic plasticity and neurotransmitter release.
Katarzyna Makasewicz +3 more
doaj +1 more source
Resident CAPS on dense-core vesicles docks and primes vesicles for fusion
Molecular Biology of the Cell, 2016 The Ca2+-dependent exocytosis of dense-core vesicles in neuroendocrine cells requires a priming step during which SNARE protein complexes assemble. CAPS (aka CADPS) is one of several factors required for vesicle priming; however, the localization and dynamics of CAPS at sites of exocytosis in live neuroendocrine cells has not been determined.
Kielar-Grevstad, D. Michelle +4 more
openaire +5 more sources
Making tau amyloid models in vitro: a crucial and underestimated challenge
FEBS Letters, EarlyView.This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley +1 more source
Acta Neuropathologica Communications, 2017 While Munc18–1 interacts with Syntaxin1 and controls the formation of soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNARE) complex to regulate presynaptic vesicle fusion in developed neurons, this molecule is likely to be ...
Nanako Hamada +3 more
doaj +1 more source