Results 71 to 80 of about 1,227,442 (389)

Fusogenic pairings of vesicle-associated membrane proteins (VAMPs) and plasma membrane t-SNAREs--VAMP5 as the exception. [PDF]

PLoS ONE, 2010
Intracellular vesicle fusion is mediated by the interactions of SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein receptor) proteins on vesicles (v-SNAREs) and on target membranes (t-SNAREs).
Nazarul Hasan, Deborah Corbin, Chuan Hu
doaj   +1 more source

Reconstituting Intracellular Vesicle Fusion Reactions: The Essential Role of Macromolecular Crowding.

Journal of the American Chemical Society, 2015
Intracellular vesicle fusion is mediated by SNAREs and Sec1/Munc18 (SM) proteins. Despite intensive efforts, the SNARE-SM mediated vesicle fusion reaction has not been faithfully reconstituted in biochemical assays.
Haijia Yu, S. Rathore, C. Shen, Yinghui Liu, Y. Ouyang, M. H. Stowell, Jingshi Shen   +6 more
semanticscholar   +1 more source

Interaction vesicles as emerging mediators of host‐pathogen molecular crosstalk and their implications for infection dynamics

FEBS Letters, EarlyView.
Interaction extracellular vesicles (iEVs) are hybrid vesicles formed through host‐pathogen communication. They facilitate immune evasion, transfer pathogens' molecules, increase host cell uptake, and enhance virulence. This Perspective article illustrates the multifunctional roles of iEVs and highlights their emerging relevance in infection dynamics ...
Bruna Sabatke, Izadora Volpato Rossi, Marcel I. Ramirez   +2 more
wiley   +1 more source

Vesicle fusion with bilayer lipid membrane controlled by electrostatic interaction

Biochemistry and Biophysics Reports, 2017
The fusion of proteoliposomes is a promising approach for incorporating membrane proteins in artificial lipid membranes. In this study, we employed an electrostatic interaction between vesicles and supported bilayer lipid membranes (s-BLMs) to control ...
Azusa Oshima, Koji Sumitomo
doaj   +1 more source

Additive effects on the energy barrier for synaptic vesicle fusion cause supralinear effects on the vesicle fusion rate

eLife, 2015
The energy required to fuse synaptic vesicles with the plasma membrane (‘activation energy’) is considered a major determinant in synaptic efficacy. From reaction rate theory, we predict that a class of modulations exists, which utilize linear modulation
S. Schotten, M. Meijer, Alexander M. Walter, Vincent Huson, Lauren E Mamer, Lawrence Kalogreades, Mirelle J T ter Veer, Marvin Ruiter, N. Brose, Christian Rosenmund, J. B. Sørensen, M. Verhage, L. N. Cornelisse   +12 more
semanticscholar   +1 more source

Presynaptic calcium and control of vesicle fusion

Current Opinion in Neurobiology, 2005
Vesicle fusion and transmitter release at synapses is driven by a highly localized Ca2+ signal that rapidly builds up around open Ca2+-channels at and near presynaptic active zones. It has been difficult to estimate the amplitude and the kinetics of this 'microdomain' signal by direct Ca2+-imaging approaches.
Schneggenburger, Ralf, Neher, Erwin
openaire   +4 more sources

Decoding the dual role of autophagy in cancer through transcriptional and epigenetic regulation

FEBS Letters, EarlyView.
Transcriptional and epigenetic regulation controls autophagy, which exerts context‐dependent effects on cancer: Autophagy suppresses tumorigenesis by maintaining cellular homeostasis or promotes tumor progression by supporting survival under stress. In this “In a Nutshell” article, we explore the intricate mechanisms of the dual function of autophagy ...
Young Suk Yu, Ik Soo Kim, Sung Hee Baek
wiley   +1 more source

A Structural Role for the Synaptobrevin 2 Transmembrane Domain in Dense-Core Vesicle Fusion Pores

Journal of Neuroscience, 2015
Ca2+-triggered release of neurotransmitters and hormones depends on soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNAREs) to drive the fusion of the vesicle and plasma membranes. The formation of the SNARE complex by the vesicle
Che-Wei Chang, E. Hui, Jihong Bai, D. Bruns, E. Chapman, M. Jackson   +5 more
semanticscholar   +1 more source

Autophagy in cancer and protein conformational disorders

FEBS Letters, EarlyView.
Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley   +1 more source

Transient fusion and selective secretion of vesicle proteins in Phytophthora nicotianae zoospores [PDF]

PeerJ, 2013
Secretion of pathogen proteins is crucial for the establishment of disease in animals and plants. Typically, early interactions between host and pathogen trigger regulated secretion of pathogenicity factors that function in pathogen adhesion and host ...
Weiwei Zhang, Leila M. Blackman, Adrienne R. Hardham   +2 more
doaj   +2 more sources